Recombinant Human Collagen Hydrogel Rapidly Reduces
Methylglyoxal Adducts within Cardiomyocytes and Improves
Borderzone Contractility after Myocardial Infarction in Mice

J 2022

Recombinant Human Collagen Hydrogel Rapidly Reduces Methylglyoxal Adducts within Cardiomyocytes and Improves Borderzone Contractility after Myocardial Infarction in Mice

MCLAUGHLIN, Sarah, Veronika SEDLÁKOVÁ, Qingzhou ZHANG, Brian MCNEILL, David SMYTH et. al.

Základní údaje

Originální název

Recombinant Human Collagen Hydrogel Rapidly Reduces Methylglyoxal Adducts within Cardiomyocytes and Improves Borderzone Contractility after Myocardial Infarction in Mice

Autoři

MCLAUGHLIN, Sarah, Veronika SEDLÁKOVÁ (203 Česká republika, domácí), Qingzhou ZHANG, Brian MCNEILL, David SMYTH, Richard SEYMOUR, Darryl R DAVIS, Marc RUEL, Marjorie BRAND, Emilio I ALARCON (garant) a Erik J SUURONEN

Vydání

Advanced Functional Materials, Wrinheim, Wiley-VCH Verlag, 2022, 1616-301X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 19.000

Kód RIV

RIV/00216224:14110/22:00126033

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/adfm.202204076

UT WoS

000801089200001

Klíčová slova anglicky

collagen hydrogels; erythroid differentiation regulator 1; methylglyoxal; myocardial infarction; ventricular remodeling

Štítky

14110517, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 1. 2023 11:02, Mgr. Tereza Miškechová

Anotace

V originále

Methylglyoxal (MG) production after myocardial infarction (MI) leads to advanced glycation end-product formation, adverse remodeling, and loss of cardiac function. The extracellular matrix (ECM) is a main target for MG glycation. This suggests that ECM-mimicking biomaterial therapies may protect the post-MI environment by removing MG. In this study, mechanisms by which a recombinant human collagen type I hydrogel therapy confers cardioprotection are investigated. One-week post-MI, mice receive intramyocardial injection of hydrogel or PBS. The hydrogel improves border zone contractility after 2 days, which is maintained for 28 days. RNA sequencing shows that hydrogel treatment decreases the expression of erythroid differentiation regulator 1, a factor associated with apoptosis. Hydrogel treatment reduces cardiomyocyte apoptosis and oxidative stress at 2 days with greater myocardial salvage seen at 28 days. The hydrogel located at the epicardial surface is modified by MG, and less MG-modified proteins are observed in the underlying myocardium of hydrogel-treated mice. Biomaterials that can be a target for MG glycation may act as a sponge to remove MG from the myocardium post-MI. This leads to less oxidative stress, greater survival and contractility of cardiomyocytes, which altogether suggests a novel mechanism by which biomaterials improve function of the infarcted heart.

Citovat

MCLAUGHLIN, Sarah, Veronika SEDLÁKOVÁ, Qingzhou ZHANG, Brian MCNEILL, David SMYTH, Richard SEYMOUR, Darryl R DAVIS, Marc RUEL, Marjorie BRAND, Emilio I ALARCON a Erik J SUURONEN. Recombinant Human Collagen Hydrogel Rapidly Reduces Methylglyoxal Adducts within Cardiomyocytes and Improves Borderzone Contractility after Myocardial Infarction in Mice. Advanced Functional Materials. Wrinheim: Wiley-VCH Verlag, 2022, roč. 32, č. 32, s. 1-15. ISSN 1616-301X. Dostupné z: https://dx.doi.org/10.1002/adfm.202204076.

@article{1860587,
   author = {McLaughlin, Sarah and Sedláková, Veronika and Zhang, Qingzhou and McNeill, Brian and Smyth, David and Seymour, Richard and Davis, Darryl R and Ruel, Marc and Brand, Marjorie and Alarcon, Emilio I and Suuronen, Erik J},
   article_location = {Wrinheim},
   article_number = {32},
   doi = {http://dx.doi.org/10.1002/adfm.202204076},
   keywords = {collagen hydrogels; erythroid differentiation regulator 1; methylglyoxal; myocardial infarction; ventricular remodeling},
   language = {eng},
   issn = {1616-301X},
   journal = {Advanced Functional Materials},
   title = {Recombinant Human Collagen Hydrogel Rapidly Reduces Methylglyoxal Adducts within Cardiomyocytes and Improves Borderzone Contractility after Myocardial Infarction in Mice},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/adfm.202204076},
   volume = {32},
   year = {2022}
}

TY  - JOUR
ID  - 1860587
AU  - McLaughlin, Sarah - Sedláková, Veronika - Zhang, Qingzhou - McNeill, Brian - Smyth, David - Seymour, Richard - Davis, Darryl R - Ruel, Marc - Brand, Marjorie - Alarcon, Emilio I - Suuronen, Erik J
PY  - 2022
TI  - Recombinant Human Collagen Hydrogel Rapidly Reduces Methylglyoxal Adducts within Cardiomyocytes and Improves Borderzone Contractility after Myocardial Infarction in Mice
JF  - Advanced Functional Materials
VL  - 32
IS  - 32
SP  - 1-15
EP  - 1-15
PB  - Wiley-VCH Verlag
SN  - 1616301X
KW  - collagen hydrogels
KW  - erythroid differentiation regulator 1
KW  - methylglyoxal
KW  - myocardial infarction
KW  - ventricular remodeling
UR  - https://onlinelibrary.wiley.com/doi/10.1002/adfm.202204076
N2  - Methylglyoxal (MG) production after myocardial infarction (MI) leads to advanced glycation end-product formation, adverse remodeling, and loss of cardiac function. The extracellular matrix (ECM) is a main target for MG glycation. This suggests that ECM-mimicking biomaterial therapies may protect the post-MI environment by removing MG. In this study, mechanisms by which a recombinant human collagen type I hydrogel therapy confers cardioprotection are investigated. One-week post-MI, mice receive intramyocardial injection of hydrogel or PBS. The hydrogel improves border zone contractility after 2 days, which is maintained for 28 days. RNA sequencing shows that hydrogel treatment decreases the expression of erythroid differentiation regulator 1, a factor associated with apoptosis. Hydrogel treatment reduces cardiomyocyte apoptosis and oxidative stress at 2 days with greater myocardial salvage seen at 28 days. The hydrogel located at the epicardial surface is modified by MG, and less MG-modified proteins are observed in the underlying myocardium of hydrogel-treated mice. Biomaterials that can be a target for MG glycation may act as a sponge to remove MG from the myocardium post-MI. This leads to less oxidative stress, greater survival and contractility of cardiomyocytes, which altogether suggests a novel mechanism by which biomaterials improve function of the infarcted heart.
ER  -

MCLAUGHLIN, Sarah, Veronika SEDLÁKOVÁ, Qingzhou ZHANG, Brian MCNEILL, David SMYTH, Richard SEYMOUR, Darryl R DAVIS, Marc RUEL, Marjorie BRAND, Emilio I ALARCON a Erik J SUURONEN. Recombinant Human Collagen Hydrogel Rapidly Reduces Methylglyoxal Adducts within Cardiomyocytes and Improves Borderzone Contractility after Myocardial Infarction in Mice. \textit{Advanced Functional Materials}. Wrinheim: Wiley-VCH Verlag, 2022, roč.~32, č.~32, s.~1-15. ISSN~1616-301X. Dostupné z: https://dx.doi.org/10.1002/adfm.202204076.

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