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@article{1860588, author = {Kotasová, Hana and Capandová, Michaela and Pelková, Vendula and Dumková, Jana and Sumbalová Koledová, Zuzana and Remšík, Ján and Souček, Karel and Garlíková, Zuzana and Sedláková, Veronika and Rabata, Anas and Vaňhara, Petr and Moráň, Lukáš and Pečinka, Lukáš and Porokh, Volodymyr and Kučírek, Martin and Streit, Libor and Havel, Josef and Hampl, Aleš}, article_location = {SEOUL}, article_number = {5}, doi = {http://dx.doi.org/10.1007/s13770-022-00458-0}, keywords = {Lung; Epithelium; hESC; Differentiation; Foregut endoderm}, language = {eng}, issn = {1738-2696}, journal = {TISSUE ENGINEERING AND REGENERATIVE MEDICINE}, title = {Expandable Lung Epithelium Differentiated from Human Embryonic Stem Cells}, url = {https://link.springer.com/article/10.1007/s13770-022-00458-0}, volume = {19}, year = {2022} }
TY - JOUR ID - 1860588 AU - Kotasová, Hana - Capandová, Michaela - Pelková, Vendula - Dumková, Jana - Sumbalová Koledová, Zuzana - Remšík, Ján - Souček, Karel - Garlíková, Zuzana - Sedláková, Veronika - Rabata, Anas - Vaňhara, Petr - Moráň, Lukáš - Pečinka, Lukáš - Porokh, Volodymyr - Kučírek, Martin - Streit, Libor - Havel, Josef - Hampl, Aleš PY - 2022 TI - Expandable Lung Epithelium Differentiated from Human Embryonic Stem Cells JF - TISSUE ENGINEERING AND REGENERATIVE MEDICINE VL - 19 IS - 5 SP - 1033-1050 EP - 1033-1050 PB - KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC SN - 17382696 KW - Lung KW - Epithelium KW - hESC KW - Differentiation KW - Foregut endoderm UR - https://link.springer.com/article/10.1007/s13770-022-00458-0 N2 - Background The progenitors to lung airway epithelium that are capable of long-term propagation may represent an attractive source of cells for cell-based therapies, disease modeling, toxicity testing, and others. Principally, there are two main options for obtaining lung epithelial progenitors: (i) direct isolation of endogenous progenitors from human lungs and (ii) in vitro differentiation from some other cell type. The prime candidates for the second approach are pluripotent stem cells, which may provide autologous and/or allogeneic cell resource in clinically relevant quality and quantity. Methods By exploiting the differentiation potential of human embryonic stem cells (hESC), here we derived expandable lung epithelium (ELEP) and established culture conditions for their long-term propagation (more than 6 months) in a monolayer culture without a need of 3D culture conditions and/or cell sorting steps, which minimizes potential variability of the outcome. Results These hESC-derived ELEP express NK2 Homeobox 1 (NKX2.1), a marker of early lung epithelial lineage, display properties of cells in early stages of surfactant production and are able to differentiate to cells exhibitting molecular and morphological characteristics of both respiratory epithelium of airway and alveolar regions. Conclusion Expandable lung epithelium thus offer a stable, convenient, easily scalable and high-yielding cell source for applications in biomedicine. ER -
KOTASOVÁ, Hana, Michaela CAPANDOVÁ, Vendula PELKOVÁ, Jana DUMKOVÁ, Zuzana SUMBALOVÁ KOLEDOVÁ, Ján REMŠÍK, Karel SOUČEK, Zuzana GARLÍKOVÁ, Veronika SEDLÁKOVÁ, Anas RABATA, Petr VAŇHARA, Lukáš MORÁŇ, Lukáš PEČINKA, Volodymyr POROKH, Martin KUČÍREK, Libor STREIT, Josef HAVEL a Aleš HAMPL. Expandable Lung Epithelium Differentiated from Human Embryonic Stem Cells. \textit{TISSUE ENGINEERING AND REGENERATIVE MEDICINE}. SEOUL: KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC, 2022, roč.~19, č.~5, s.~1033-1050. ISSN~1738-2696. Dostupné z: https://dx.doi.org/10.1007/s13770-022-00458-0.
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