The blood-brain barrier and the neurovascular unit in
subarachnoid hemorrhage: molecular events and potential
treatments

J 2022

The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments

SOLÁR, Peter, Alemeh ZAMANI, Klaudia LAKATOSOVÁ a Marek JOUKAL

Základní údaje

Originální název

The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments

Autoři

SOLÁR, Peter (703 Slovensko, domácí), Alemeh ZAMANI (364 Írán, domácí), Klaudia LAKATOSOVÁ (703 Slovensko, domácí) a Marek JOUKAL (203 Česká republika, garant, domácí)

Vydání

FLUIDS AND BARRIERS OF THE CNS, LONDON, BMC, 2022, 2045-8118

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.300

Kód RIV

RIV/00216224:14110/22:00126060

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1186/s12987-022-00312-4

UT WoS

000780995700001

Klíčová slova anglicky

Subarachnoid hemorrhage; Blood-brain barrier; Subarachnoid hemorrhage treatment; Neuronal injury; Neurovascular unit; Neuroinflammation

Štítky

14110131, 14110514, rivok

Příznaky

Recenzováno

Změněno: 16. 1. 2023 14:09, Mgr. Tereza Miškechová

Anotace

V originále

The response of the blood-brain barrier (BBB) following a stroke, including subarachnoid hemorrhage (SAH), has been studied extensively. The main components of this reaction are endothelial cells, pericytes, and astrocytes that affect microglia, neurons, and vascular smooth muscle cells. SAH induces alterations in individual BBB cells, leading to brain homeostasis disruption. Recent experiments have uncovered many pathophysiological cascades affecting the BBB following SAH. Targeting some of these pathways is important for restoring brain function following SAH. BBB injury occurs immediately after SAH and has long-lasting consequences, but most changes in the pathophysiological cascades occur in the first few days following SAH. These changes determine the development of early brain injury as well as delayed cerebral ischemia. SAH-induced neuroprotection also plays an important role and weakens the negative impact of SAH. Supporting some of these beneficial cascades while attenuating the major pathophysiological pathways might be decisive in inhibiting the negative impact of bleeding in the subarachnoid space. In this review, we attempt a comprehensive overview of the current knowledge on the molecular and cellular changes in the BBB following SAH and their possible modulation by various drugs and substances.

Návaznosti

EF16_027/0008360, projekt VaV

Název: Postdoc@MUNI

MUNI/A/0975/2019, interní kód MU

Název: Studium změn ve strukturách nervové soustavy po poškození

Investor: Masarykova univerzita, Studium změn ve strukturách nervové soustavy po poškození, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

MUNI/A/1520/2020, interní kód MU

Název: Změny ve strukturách nervové soustavy v reakci na poškození

Investor: Masarykova univerzita, Změny ve strukturách nervové soustavy v reakci na poškození

ROZV/23/LF14/2019, interní kód MU

Název: Elektrofyziologická a imunohistochemická studie změn podmíněných neurozánětem ve spinálních gangliích neasociovaných s poškozeným periferním nervem

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Elektrofyziologická a imunohistochemická studie změn podmíněných neurozánětem ve spinálních gangliích neasociovaných s poškozeným periferním nervem, Interní rozvojové projekty

Citovat

SOLÁR, Peter, Alemeh ZAMANI, Klaudia LAKATOSOVÁ a Marek JOUKAL. The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments. FLUIDS AND BARRIERS OF THE CNS. LONDON: BMC, 2022, roč. 19, č. 1, s. 1-79. ISSN 2045-8118. Dostupné z: https://dx.doi.org/10.1186/s12987-022-00312-4.

@article{1861457,
   author = {Solár, Peter and Zamani, Alemeh and Lakatosová, Klaudia and Joukal, Marek},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s12987-022-00312-4},
   keywords = {Subarachnoid hemorrhage; Blood-brain barrier; Subarachnoid hemorrhage treatment; Neuronal injury; Neurovascular unit; Neuroinflammation},
   language = {eng},
   issn = {2045-8118},
   journal = {FLUIDS AND BARRIERS OF THE CNS},
   title = {The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments},
   url = {http://dx.doi.org/10.1186/s12987-022-00312-4},
   volume = {19},
   year = {2022}
}

TY  - JOUR
ID  - 1861457
AU  - Solár, Peter - Zamani, Alemeh - Lakatosová, Klaudia - Joukal, Marek
PY  - 2022
TI  - The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments
JF  - FLUIDS AND BARRIERS OF THE CNS
VL  - 19
IS  - 1
SP  - 1-79
EP  - 1-79
PB  - BMC
SN  - 20458118
KW  - Subarachnoid hemorrhage
KW  - Blood-brain barrier
KW  - Subarachnoid hemorrhage treatment
KW  - Neuronal injury
KW  - Neurovascular unit
KW  - Neuroinflammation
UR  - http://dx.doi.org/10.1186/s12987-022-00312-4
N2  - The response of the blood-brain barrier (BBB) following a stroke, including subarachnoid hemorrhage (SAH), has been studied extensively. The main components of this reaction are endothelial cells, pericytes, and astrocytes that affect microglia, neurons, and vascular smooth muscle cells. SAH induces alterations in individual BBB cells, leading to brain homeostasis disruption. Recent experiments have uncovered many pathophysiological cascades affecting the BBB following SAH. Targeting some of these pathways is important for restoring brain function following SAH. BBB injury occurs immediately after SAH and has long-lasting consequences, but most changes in the pathophysiological cascades occur in the first few days following SAH. These changes determine the development of early brain injury as well as delayed cerebral ischemia. SAH-induced neuroprotection also plays an important role and weakens the negative impact of SAH. Supporting some of these beneficial cascades while attenuating the major pathophysiological pathways might be decisive in inhibiting the negative impact of bleeding in the subarachnoid space. In this review, we attempt a comprehensive overview of the current knowledge on the molecular and cellular changes in the BBB following SAH and their possible modulation by various drugs and substances.
ER  -

SOLÁR, Peter, Alemeh ZAMANI, Klaudia LAKATOSOVÁ a Marek JOUKAL. The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments. \textit{FLUIDS AND BARRIERS OF THE CNS}. LONDON: BMC, 2022, roč.~19, č.~1, s.~1-79. ISSN~2045-8118. Dostupné z: https://dx.doi.org/10.1186/s12987-022-00312-4.

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