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@article{1861457,
author = {Solár, Peter and Zamani, Alemeh and Lakatosová, Klaudia and Joukal, Marek},
article_location = {LONDON},
article_number = {1},
doi = {http://dx.doi.org/10.1186/s12987-022-00312-4},
keywords = {Subarachnoid hemorrhage; Blood-brain barrier; Subarachnoid hemorrhage treatment; Neuronal injury; Neurovascular unit; Neuroinflammation},
language = {eng},
issn = {2045-8118},
journal = {FLUIDS AND BARRIERS OF THE CNS},
title = {The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments},
url = {http://dx.doi.org/10.1186/s12987-022-00312-4},
volume = {19},
year = {2022}
}
TY - JOUR
ID - 1861457
AU - Solár, Peter - Zamani, Alemeh - Lakatosová, Klaudia - Joukal, Marek
PY - 2022
TI - The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments
JF - FLUIDS AND BARRIERS OF THE CNS
VL - 19
IS - 1
SP - 1-79
EP - 1-79
PB - BMC
SN - 20458118
KW - Subarachnoid hemorrhage
KW - Blood-brain barrier
KW - Subarachnoid hemorrhage treatment
KW - Neuronal injury
KW - Neurovascular unit
KW - Neuroinflammation
UR - http://dx.doi.org/10.1186/s12987-022-00312-4
N2 - The response of the blood-brain barrier (BBB) following a stroke, including subarachnoid hemorrhage (SAH), has been studied extensively. The main components of this reaction are endothelial cells, pericytes, and astrocytes that affect microglia, neurons, and vascular smooth muscle cells. SAH induces alterations in individual BBB cells, leading to brain homeostasis disruption. Recent experiments have uncovered many pathophysiological cascades affecting the BBB following SAH. Targeting some of these pathways is important for restoring brain function following SAH. BBB injury occurs immediately after SAH and has long-lasting consequences, but most changes in the pathophysiological cascades occur in the first few days following SAH. These changes determine the development of early brain injury as well as delayed cerebral ischemia. SAH-induced neuroprotection also plays an important role and weakens the negative impact of SAH. Supporting some of these beneficial cascades while attenuating the major pathophysiological pathways might be decisive in inhibiting the negative impact of bleeding in the subarachnoid space. In this review, we attempt a comprehensive overview of the current knowledge on the molecular and cellular changes in the BBB following SAH and their possible modulation by various drugs and substances.
ER -
SOLÁR, Peter, Alemeh ZAMANI, Klaudia LAKATOSOVÁ a Marek JOUKAL. The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments. \textit{FLUIDS AND BARRIERS OF THE CNS}. LONDON: BMC, 2022, roč.~19, č.~1, s.~1-79. ISSN~2045-8118. Dostupné z: https://dx.doi.org/10.1186/s12987-022-00312-4.
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