2022
The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments
SOLÁR, Peter, Alemeh ZAMANI, Klaudia LAKATOSOVÁ a Marek JOUKALZákladní údaje
Originální název
The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments
Autoři
SOLÁR, Peter (703 Slovensko, domácí), Alemeh ZAMANI (364 Írán, domácí), Klaudia LAKATOSOVÁ (703 Slovensko, domácí) a Marek JOUKAL (203 Česká republika, garant, domácí)
Vydání
FLUIDS AND BARRIERS OF THE CNS, LONDON, BMC, 2022, 2045-8118
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30103 Neurosciences
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 7.300
Kód RIV
RIV/00216224:14110/22:00126060
Organizační jednotka
Lékařská fakulta
UT WoS
000780995700001
Klíčová slova anglicky
Subarachnoid hemorrhage; Blood-brain barrier; Subarachnoid hemorrhage treatment; Neuronal injury; Neurovascular unit; Neuroinflammation
Příznaky
Recenzováno
Změněno: 16. 1. 2023 14:09, Mgr. Tereza Miškechová
Anotace
V originále
The response of the blood-brain barrier (BBB) following a stroke, including subarachnoid hemorrhage (SAH), has been studied extensively. The main components of this reaction are endothelial cells, pericytes, and astrocytes that affect microglia, neurons, and vascular smooth muscle cells. SAH induces alterations in individual BBB cells, leading to brain homeostasis disruption. Recent experiments have uncovered many pathophysiological cascades affecting the BBB following SAH. Targeting some of these pathways is important for restoring brain function following SAH. BBB injury occurs immediately after SAH and has long-lasting consequences, but most changes in the pathophysiological cascades occur in the first few days following SAH. These changes determine the development of early brain injury as well as delayed cerebral ischemia. SAH-induced neuroprotection also plays an important role and weakens the negative impact of SAH. Supporting some of these beneficial cascades while attenuating the major pathophysiological pathways might be decisive in inhibiting the negative impact of bleeding in the subarachnoid space. In this review, we attempt a comprehensive overview of the current knowledge on the molecular and cellular changes in the BBB following SAH and their possible modulation by various drugs and substances.
Návaznosti
| EF16_027/0008360, projekt VaV |
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| MUNI/A/0975/2019, interní kód MU |
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| MUNI/A/1520/2020, interní kód MU |
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| ROZV/23/LF14/2019, interní kód MU |
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