Application of a pharmacokinetic model in characterizing
sources of polychlorinated biphenyl exposure and determining
threshold daily intakes for adverse health effects in infants
and toddlers

J 2022

Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers

KOMPRDOVÁ, Klára, Elena DOMINGUEZ ROMERO, Brij Mohan SHARMA, Jiří KOMPRDA, Lisa Emily MELYMUK et. al.

Základní údaje

Originální název

Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers

Autoři

KOMPRDOVÁ, Klára (203 Česká republika, domácí), Elena DOMINGUEZ ROMERO (724 Španělsko, domácí), Brij Mohan SHARMA (356 Indie, domácí), Jiří KOMPRDA (203 Česká republika, domácí), Lisa Emily MELYMUK (124 Kanada, domácí), Ľubica MURÍNOVÁ PALKOVIČOVÁ, Kamil ČONKA (703 Slovensko), Tomáš TRNOVEC (703 Slovensko), Milena ČERNÁ, Beata DROBNÁ, Anna FABIŠIKOVÁ, Zuzana SEJÁKOVÁ STACHOVÁ a Martin SCHERINGER (756 Švýcarsko, garant, domácí)

Vydání

Science of the Total Environment, Amsterdam, Elsevier Science, 2022, 0048-9697

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 9.800

Kód RIV

RIV/00216224:14310/22:00126067

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.scitotenv.2022.154734

UT WoS

000804450300005

Klíčová slova anglicky

Polychlorinated biphenyls; Human biomonieming; Physiologically based pharmacokinetic model; Daily intakes; Safety standards; Infant exposure

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 6. 2022 13:37, Mgr. Marie Šípková, DiS.

Anotace

V originále

Characterization of PCB exposure sources for vulnerable population groups is essential to minimize the health effects of PCB exposure. At the same time, it is important to consolidate the knowledge on threshold intakes of PCBs for infants and toddlers to prevent health effects. We estimated total PCB concentrations from birth to 2 years of age in children from Slovak and Czech populations, which continue to have high PCB concentrations in breast milk. Using a pharmacokinctic (PK) model, we characterized dominant PCB exposure sources and estimated new threshold estimated daily intakes (TEDI) (above which adverse effects cannot be excluded) for postnatal PCB exposure in infants and toddlers. In the PK model, concentrations of seven indicator PCBs in breast milk and cord blood samples from 291 mother-child pairs from the Slovak birth cohort, and 396 breast milk samples from Czech mothers we used, together with their physiological characteristics and PCB concentrations from other exposure sources (food, dust, air). The estimated total PCB concentrations in children's blood at different ages were compared with threshold PCB concentrations of 500, 700 and 1000 ng.g(lipid)(-1)( )in serum proposed by the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) and the German Environment Agency (UBA), above which possible adverse health effects may be expected. We estimated that up to 20.6% of Slovak children and up to 45.7% of Czech children at two years of age exceeded the threshold value of 700 ng.g(lipid)(-1 )in blood. Mean TEDIs leading to values of 500 ng.g(lipid)(-1) in blood for children up to two years ranged between 110 and 220 ng.kg(-1).bw.day(-1), varying according to breastfeeding duration. Breast milk and prenatal exposure contributed to 71 %-85% of PCBs exposure at two years of age. In contrast, the contributions of PCBs fmm dust and indoor air were negligible.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

LM2018121, projekt VaV

Název: Výzkumná infrastruktura RECETOX (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI

Přiložené soubory

1861580.pdf

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Citovat

KOMPRDOVÁ, Klára, Elena DOMINGUEZ ROMERO, Brij Mohan SHARMA, Jiří KOMPRDA, Lisa Emily MELYMUK, Ľubica MURÍNOVÁ PALKOVIČOVÁ, Kamil ČONKA, Tomáš TRNOVEC, Milena ČERNÁ, Beata DROBNÁ, Anna FABIŠIKOVÁ, Zuzana SEJÁKOVÁ STACHOVÁ a Martin SCHERINGER. Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers. Science of the Total Environment. Amsterdam: Elsevier Science, 2022, roč. 830, July 2022, s. 1-9. ISSN 0048-9697. Dostupné z: https://dx.doi.org/10.1016/j.scitotenv.2022.154734.

@article{1861580,
   author = {Komprdová, Klára and Dominguez Romero, Elena and Sharma, Brij Mohan and Komprda, Jiří and Melymuk, Lisa Emily and Murínová Palkovičová, Ľubica and Čonka, Kamil and Trnovec, Tomáš and Černá, Milena and Drobná, Beata and Fabišiková, Anna and Sejáková Stachová, Zuzana and Scheringer, Martin},
   article_location = {Amsterdam},
   article_number = {July 2022},
   doi = {http://dx.doi.org/10.1016/j.scitotenv.2022.154734},
   keywords = {Polychlorinated biphenyls; Human biomonieming; Physiologically based pharmacokinetic model; Daily intakes; Safety standards; Infant exposure},
   language = {eng},
   issn = {0048-9697},
   journal = {Science of the Total Environment},
   title = {Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers},
   url = {https://www.sciencedirect.com/science/article/pii/S0048969722018277?via%3Dihub},
   volume = {830},
   year = {2022}
}

TY  - JOUR
ID  - 1861580
AU  - Komprdová, Klára - Dominguez Romero, Elena - Sharma, Brij Mohan - Komprda, Jiří - Melymuk, Lisa Emily - Murínová Palkovičová, Ľubica - Čonka, Kamil - Trnovec, Tomáš - Černá, Milena - Drobná, Beata - Fabišiková, Anna - Sejáková Stachová, Zuzana - Scheringer, Martin
PY  - 2022
TI  - Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers
JF  - Science of the Total Environment
VL  - 830
IS  - July 2022
SP  - 1-9
EP  - 1-9
PB  - Elsevier Science
SN  - 00489697
KW  - Polychlorinated biphenyls
KW  - Human biomonieming
KW  - Physiologically based pharmacokinetic model
KW  - Daily intakes
KW  - Safety standards
KW  - Infant exposure
UR  - https://www.sciencedirect.com/science/article/pii/S0048969722018277?via%3Dihub
N2  - Characterization of PCB exposure sources for vulnerable population groups is essential to minimize the health effects of PCB exposure. At the same time, it is important to consolidate the knowledge on threshold intakes of PCBs for infants and toddlers to prevent health effects. We estimated total PCB concentrations from birth to 2 years of age in children from Slovak and Czech populations, which continue to have high PCB concentrations in breast milk. Using a pharmacokinctic (PK) model, we characterized dominant PCB exposure sources and estimated new threshold estimated daily intakes (TEDI) (above which adverse effects cannot be excluded) for postnatal PCB exposure in infants and toddlers. In the PK model, concentrations of seven indicator PCBs in breast milk and cord blood samples from 291 mother-child pairs from the Slovak birth cohort, and 396 breast milk samples from Czech mothers we used, together with their physiological characteristics and PCB concentrations from other exposure sources (food, dust, air). The estimated total PCB concentrations in children's blood at different ages were compared with threshold PCB concentrations of 500, 700 and 1000 ng.g(lipid)(-1)( )in serum proposed by the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) and the German Environment Agency (UBA), above which possible adverse health effects may be expected. We estimated that up to 20.6% of Slovak children and up to 45.7% of Czech children at two years of age exceeded the threshold value of 700 ng.g(lipid)(-1 )in blood. Mean TEDIs leading to values of 500 ng.g(lipid)(-1) in blood for children up to two years ranged between 110 and 220 ng.kg(-1).bw.day(-1), varying according to breastfeeding duration. Breast milk and prenatal exposure contributed to 71 %-85% of PCBs exposure at two years of age. In contrast, the contributions of PCBs fmm dust and indoor air were negligible.
ER  -

KOMPRDOVÁ, Klára, Elena DOMINGUEZ ROMERO, Brij Mohan SHARMA, Jiří KOMPRDA, Lisa Emily MELYMUK, Ľubica MURÍNOVÁ PALKOVIČOVÁ, Kamil ČONKA, Tomáš TRNOVEC, Milena ČERNÁ, Beata DROBNÁ, Anna FABIŠIKOVÁ, Zuzana SEJÁKOVÁ STACHOVÁ a Martin SCHERINGER. Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers. \textit{Science of the Total Environment}. Amsterdam: Elsevier Science, 2022, roč.~830, July 2022, s.~1-9. ISSN~0048-9697. Dostupné z: https://dx.doi.org/10.1016/j.scitotenv.2022.154734.

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