Oncological outcomes of surgery for isolated retroperitoneal
recurrence in renal cancer patients after radical nephrectomy

J 2022

Oncological outcomes of surgery for isolated retroperitoneal recurrence in renal cancer patients after radical nephrectomy

STANÍK, Michal, Alexandr POPRACH, Simona LITTNEROVÁ, Ivo CAPAK, Marketa HULOVA et. al.

Základní údaje

Originální název

Oncological outcomes of surgery for isolated retroperitoneal recurrence in renal cancer patients after radical nephrectomy

Autoři

STANÍK, Michal (703 Slovensko, garant), Alexandr POPRACH (203 Česká republika, domácí), Simona LITTNEROVÁ (203 Česká republika, domácí), Ivo CAPAK (203 Česká republika), Marketa HULOVA (203 Česká republika), Natalia SEBOVA, Radek LAKOMÝ (203 Česká republika, domácí), Jiří JARKOVSKÝ (203 Česká republika, domácí) a Jan DOLEZEL (203 Česká republika)

Vydání

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, New York, ELSEVIER SCIENCE INC. 2022, 1078-1439

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.700

Kód RIV

RIV/00216224:14110/22:00129672

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.urolonc.2021.11.028

UT WoS

000762247800031

Klíčová slova anglicky

Renal cancer; Nephrectomy; Local neoplasm recurrence; Metastasis; Metastasectomy

Štítky

14110811, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 6. 2022 12:45, Mgr. Tereza Miškechová

Anotace

V originále

Aims: Isolated retroperitoneal recurrence (IRR) in renal cancer patients after radical nephrectomy (RN) is a rare event and poses a therapeutic dilemma. We evaluated oncologic outcomes in surgically treated patients with IRR and established prognostic factors associated with survival. The benefit of metastasis-directed therapy (MDT) in those with clinical progression after extirpation of IRR was assessed. Methods: This was a retrospective single-institutional study in which 60 renal cancer patients after previous RN underwent surgery for suspicion of IRR within the period of 2004-2019; in 55 of them, RCC recurrence was histologically confirmed. No patient had distant metastatic disease at the time of IRR diagnosis. In cases of clinical progression after IRR surgery, MDT (metastasectomy, stereotactic radiotherapy) was selectively used. Kaplan-Meier curves were used to estimate survival outcomes. Univariable and multivariable Cox proportional hazards regression analyses were used to evaluate associations between clinicopathological parameters and cancer-specific survival. Results: Median age at IRR diagnosis was 64 years (range 23-81). IRR was diagnosed at a median of 42 months (IQR 19-99) after RN. Surgical complications of grade 3-5 after IRR extirpation were rare (7%). Median follow-up time was 50 months (IQR 19-80). Five-year recurrence-free survival and cancer-specific survival rates were 32% and 66%, respectively. Radiographic progression was observed in 34 (62%) patients at a median of 11 months after IRR surgery, out of which 22 patients (40%) underwent MDT. When compared with 12 patients without MDT, the MDT patients had a prolonged median time to systemic treatment of 58 (vs. 16 months), and median cancer-specific survival of 88 (vs. 46 months). Upon multivariable analysis, the interval from nephrectomy <= 12 months (HR 7.77), tumour grade 3-4 (HR 13.24) and female sex (HR 7.42) were determined to be independent prognostic factors of cancer-related mortality. Conclusion: Aggressive surgical therapy of IRR is feasible with relatively low morbidity. More than half of the patients experience long-term survival. The interval from nephrectomy to IRR less than 12 months, tumour grade 3-4 and female sex were negative prognostic predictors. In the case of progression, metastasis-directed therapy may prolong the interval to initiation of systemic treatment.

Návaznosti

NV18-03-00554, projekt VaV

Název: Molekulární klasifikace renálního buněčného karcinomu založená na expresi dlouhých nekódujících RNA a její využití v diagnostice, předpovědi prognózy a terapii

Investor: Ministerstvo zdravotnictví ČR, Molecular classification of renal cell carcinoma based on long noncoding RNAs expression and its implication for diagnosis, prognosis and therapy

Citovat

STANÍK, Michal, Alexandr POPRACH, Simona LITTNEROVÁ, Ivo CAPAK, Marketa HULOVA, Natalia SEBOVA, Radek LAKOMÝ, Jiří JARKOVSKÝ a Jan DOLEZEL. Oncological outcomes of surgery for isolated retroperitoneal recurrence in renal cancer patients after radical nephrectomy. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS. New York: ELSEVIER SCIENCE INC., 2022, roč. 40, č. 3, s. "111.e27"-"111.e34", 8 s. ISSN 1078-1439. Dostupné z: https://dx.doi.org/10.1016/j.urolonc.2021.11.028.

@article{1863110,
   author = {Staník, Michal and Poprach, Alexandr and Littnerová, Simona and Capak, Ivo and Hulova, Marketa and Sebova, Natalia and Lakomý, Radek and Jarkovský, Jiří and Dolezel, Jan},
   article_location = {New York},
   article_number = {3},
   doi = {http://dx.doi.org/10.1016/j.urolonc.2021.11.028},
   keywords = {Renal cancer; Nephrectomy; Local neoplasm recurrence; Metastasis; Metastasectomy},
   language = {eng},
   issn = {1078-1439},
   journal = {UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS},
   title = {Oncological outcomes of surgery for isolated retroperitoneal recurrence in renal cancer patients after radical nephrectomy},
   url = {https://www.sciencedirect.com/science/article/pii/S1078143921005445?via%3Dihub},
   volume = {40},
   year = {2022}
}

TY  - JOUR
ID  - 1863110
AU  - Staník, Michal - Poprach, Alexandr - Littnerová, Simona - Capak, Ivo - Hulova, Marketa - Sebova, Natalia - Lakomý, Radek - Jarkovský, Jiří - Dolezel, Jan
PY  - 2022
TI  - Oncological outcomes of surgery for isolated retroperitoneal recurrence in renal cancer patients after radical nephrectomy
JF  - UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
VL  - 40
IS  - 3
SP  - "111.e27"-"111.e34"
EP  - "111.e27"-"111.e34"
PB  - ELSEVIER SCIENCE INC.
SN  - 10781439
KW  - Renal cancer
KW  - Nephrectomy
KW  - Local neoplasm recurrence
KW  - Metastasis
KW  - Metastasectomy
UR  - https://www.sciencedirect.com/science/article/pii/S1078143921005445?via%3Dihub
N2  - Aims: Isolated retroperitoneal recurrence (IRR) in renal cancer patients after radical nephrectomy (RN) is a rare event and poses a therapeutic dilemma. We evaluated oncologic outcomes in surgically treated patients with IRR and established prognostic factors associated with survival. The benefit of metastasis-directed therapy (MDT) in those with clinical progression after extirpation of IRR was assessed. Methods: This was a retrospective single-institutional study in which 60 renal cancer patients after previous RN underwent surgery for suspicion of IRR within the period of 2004-2019; in 55 of them, RCC recurrence was histologically confirmed. No patient had distant metastatic disease at the time of IRR diagnosis. In cases of clinical progression after IRR surgery, MDT (metastasectomy, stereotactic radiotherapy) was selectively used. Kaplan-Meier curves were used to estimate survival outcomes. Univariable and multivariable Cox proportional hazards regression analyses were used to evaluate associations between clinicopathological parameters and cancer-specific survival. Results: Median age at IRR diagnosis was 64 years (range 23-81). IRR was diagnosed at a median of 42 months (IQR 19-99) after RN. Surgical complications of grade 3-5 after IRR extirpation were rare (7%). Median follow-up time was 50 months (IQR 19-80). Five-year recurrence-free survival and cancer-specific survival rates were 32% and 66%, respectively. Radiographic progression was observed in 34 (62%) patients at a median of 11 months after IRR surgery, out of which 22 patients (40%) underwent MDT. When compared with 12 patients without MDT, the MDT patients had a prolonged median time to systemic treatment of 58 (vs. 16 months), and median cancer-specific survival of 88 (vs. 46 months). Upon multivariable analysis, the interval from nephrectomy <= 12 months (HR 7.77), tumour grade 3-4 (HR 13.24) and female sex (HR 7.42) were determined to be independent prognostic factors of cancer-related mortality. Conclusion: Aggressive surgical therapy of IRR is feasible with relatively low morbidity. More than half of the patients experience long-term survival. The interval from nephrectomy to IRR less than 12 months, tumour grade 3-4 and female sex were negative prognostic predictors. In the case of progression, metastasis-directed therapy may prolong the interval to initiation of systemic treatment.
ER  -

STANÍK, Michal, Alexandr POPRACH, Simona LITTNEROVÁ, Ivo CAPAK, Marketa HULOVA, Natalia SEBOVA, Radek LAKOMÝ, Jiří JARKOVSKÝ a Jan DOLEZEL. Oncological outcomes of surgery for isolated retroperitoneal recurrence in renal cancer patients after radical nephrectomy. \textit{UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS}. New York: ELSEVIER SCIENCE INC., 2022, roč.~40, č.~3, s.~''111.e27''-''111.e34'', 8 s. ISSN~1078-1439. Dostupné z: https://dx.doi.org/10.1016/j.urolonc.2021.11.028.

Podrobný výpis o publikaci