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@article{1863221,
author = {Barouki, Robert and Audouze, Karine and Becker, Christel and Bláha, Luděk and Coumoul, Xavier and Karakitsios, Spyros and Klánová, Jana and Miller, Gary W. and Price, Elliott James and Sarigiannis, Denis},
article_location = {OXFORD},
article_number = {1},
doi = {http://dx.doi.org/10.1093/toxsci/kfab149},
keywords = {multiple stress; adverse outcome pathways; mixtures; epigenetics; chemical toxicity},
language = {eng},
issn = {1096-6080},
journal = {Toxicological sciences},
title = {The Exposome and Toxicology: A Win-Win Collaboration},
url = {https://academic.oup.com/toxsci/article/186/1/1/6456323?login=true},
volume = {186},
year = {2022}
}
TY - JOUR
ID - 1863221
AU - Barouki, Robert - Audouze, Karine - Becker, Christel - Bláha, Luděk - Coumoul, Xavier - Karakitsios, Spyros - Klánová, Jana - Miller, Gary W. - Price, Elliott James - Sarigiannis, Denis
PY - 2022
TI - The Exposome and Toxicology: A Win-Win Collaboration
JF - Toxicological sciences
VL - 186
IS - 1
SP - 1-11
EP - 1-11
PB - Academic Press
SN - 10966080
KW - multiple stress
KW - adverse outcome pathways
KW - mixtures
KW - epigenetics
KW - chemical toxicity
UR - https://academic.oup.com/toxsci/article/186/1/1/6456323?login=true
N2 - The development of the exposome concept has been one of the hallmarks of environmental and health research for the last decade. The exposome encompasses the life course environmental exposures including lifestyle factors from the prenatal period onwards. It has inspired many research programs and is expected to influence environmental and health research, practices, and policies. Yet, the links bridging toxicology and the exposome concept have not been well developed. In this review, we describe how the exposome framework can interface with and influence the field of toxicology, as well as how the field of toxicology can help advance the exposome field by providing the needed mechanistic understanding of the exposome impacts on health. Indeed, exposome-informed toxicology is expected to emphasize several orientations including (1) developing approaches integrating multiple stressors, in particular chemical mixtures, as well as the interaction of chemicals with other stressors, (2) using mechanistic frameworks such as the adverse outcome pathways to link the different stressors with toxicity outcomes, (3) characterizing the mechanistic basis of long-term effects by distinguishing different patterns of exposures and further exploring the environment-DNA interface through genetic and epigenetic studies, and (4) improving the links between environmental and human health, in particular through a stronger connection between alterations in our ecosystems and human toxicology. The exposome concept provides the linkage between the complex environment and contemporary mechanistic toxicology. What toxicology can bring to exposome characterization is a needed framework for mechanistic understanding and regulatory outcomes in risk assessment.
ER -
BAROUKI, Robert, Karine AUDOUZE, Christel BECKER, Luděk BLÁHA, Xavier COUMOUL, Spyros KARAKITSIOS, Jana KLÁNOVÁ, Gary W. MILLER, Elliott James PRICE a Denis SARIGIANNIS. The Exposome and Toxicology: A Win-Win Collaboration. \textit{Toxicological sciences}. OXFORD: Academic Press, 2022, roč.~186, č.~1, s.~1-11. ISSN~1096-6080. Dostupné z: https://dx.doi.org/10.1093/toxsci/kfab149.
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