Chalcogen-based ratiometric reversible BODIPY redox sensors for
the determination of enantioselective methionine sulfoxide
reductase activity

J 2022

Chalcogen-based ratiometric reversible BODIPY redox sensors for the determination of enantioselective methionine sulfoxide reductase activity

POLJAK, Michal, Lucie WOHLRABOVA, Eduardo PALAO UTIEL, Jela NOCIAROVÁ, Jiri MISEK et. al.

Základní údaje

Originální název

Chalcogen-based ratiometric reversible BODIPY redox sensors for the determination of enantioselective methionine sulfoxide reductase activity

Autoři

POLJAK, Michal (703 Slovensko, domácí), Lucie WOHLRABOVA, Eduardo PALAO UTIEL (724 Španělsko, domácí), Jela NOCIAROVÁ (703 Slovensko, domácí), Jiri MISEK, Tomáš SLANINA (203 Česká republika) a Petr KLÁN (203 Česká republika, garant, domácí)

Vydání

Chemical Communications, Royal Society of Chemistry, 2022, 1359-7345

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10400 1.4 Chemical sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.900

Kód RIV

RIV/00216224:14310/22:00126180

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1039/d2cc02016e

UT WoS

000793297200001

Klíčová slova anglicky

FLUORESCENT-PROBES; OXIDATIVE STRESS; HYDROGEN-SULFIDE; SE-BODIPY; CYCLE; SELENOXIDE; PROTEIN; REPAIR; ACID

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 3. 2023 22:46, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Many serious diseases are associated with degenerative changes caused by oxidative stress triggered by elevated concentrations of reactive oxygen species (ROS) in cells. Therefore, the development of suitable probes for monitoring such processes is of great importance. Here, we introduce a series of sulfur- and selenium-substituted BODIPY derivatives as reversible redox sensors for ROS and enzymatic redox processes. Significant differences in emission maxima and fluorescence quantum yields between the reduced and oxidized forms make them excellent ratiometric turn-on/off probes. Installation of polar sulfonate groups improved their aqueous solubility while retaining their sensing properties, which allowed the probes to monitor the enzymatic activity of enantioselective methionine sulfoxide reductase.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

LM2018121, projekt VaV

Název: Výzkumná infrastruktura RECETOX (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

Citovat

POLJAK, Michal, Lucie WOHLRABOVA, Eduardo PALAO UTIEL, Jela NOCIAROVÁ, Jiri MISEK, Tomáš SLANINA a Petr KLÁN. Chalcogen-based ratiometric reversible BODIPY redox sensors for the determination of enantioselective methionine sulfoxide reductase activity. Chemical Communications. Royal Society of Chemistry, 2022, roč. 58, č. 44, s. 6389-6392. ISSN 1359-7345. Dostupné z: https://dx.doi.org/10.1039/d2cc02016e.

@article{1863616,
   author = {Poljak, Michal and Wohlrabova, Lucie and Palao Utiel, Eduardo and Nociarová, Jela and Misek, Jiri and Slanina, Tomáš and Klán, Petr},
   article_number = {44},
   doi = {http://dx.doi.org/10.1039/d2cc02016e},
   keywords = {FLUORESCENT-PROBES; OXIDATIVE STRESS; HYDROGEN-SULFIDE; SE-BODIPY; CYCLE; SELENOXIDE; PROTEIN; REPAIR; ACID},
   language = {eng},
   issn = {1359-7345},
   journal = {Chemical Communications},
   title = {Chalcogen-based ratiometric reversible BODIPY redox sensors for the determination of enantioselective methionine sulfoxide reductase activity},
   url = {https://www.scopus.com/record/display.uri?eid=2-s2.0-85131224229&origin=resultslist&sort=plf-f&src=s&st1=10.1039%2fd2cc02016e&sid=fb45a799d1eb2aeaaeb4725c07aa1af4&sot=b&sdt=b&sl=23&s=DOI%2810.1039%2fd2cc02016e%29&relpos=0&citeCnt=0&searchTerm=&featureTog},
   volume = {58},
   year = {2022}
}

TY  - JOUR
ID  - 1863616
AU  - Poljak, Michal - Wohlrabova, Lucie - Palao Utiel, Eduardo - Nociarová, Jela - Misek, Jiri - Slanina, Tomáš - Klán, Petr
PY  - 2022
TI  - Chalcogen-based ratiometric reversible BODIPY redox sensors for the determination of enantioselective methionine sulfoxide reductase activity
JF  - Chemical Communications
VL  - 58
IS  - 44
SP  - 6389-6392
EP  - 6389-6392
PB  - Royal Society of Chemistry
SN  - 13597345
KW  - FLUORESCENT-PROBES
KW  - OXIDATIVE STRESS
KW  - HYDROGEN-SULFIDE
KW  - SE-BODIPY
KW  - CYCLE
KW  - SELENOXIDE
KW  - PROTEIN
KW  - REPAIR
KW  - ACID
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-85131224229&origin=resultslist&sort=plf-f&src=s&st1=10.1039%2fd2cc02016e&sid=fb45a799d1eb2aeaaeb4725c07aa1af4&sot=b&sdt=b&sl=23&s=DOI%2810.1039%2fd2cc02016e%29&relpos=0&citeCnt=0&searchTerm=&featureTog
N2  - Many serious diseases are associated with degenerative changes caused by oxidative stress triggered by elevated concentrations of reactive oxygen species (ROS) in cells. Therefore, the development of suitable probes for monitoring such processes is of great importance. Here, we introduce a series of sulfur- and selenium-substituted BODIPY derivatives as reversible redox sensors for ROS and enzymatic redox processes. Significant differences in emission maxima and fluorescence quantum yields between the reduced and oxidized forms make them excellent ratiometric turn-on/off probes. Installation of polar sulfonate groups improved their aqueous solubility while retaining their sensing properties, which allowed the probes to monitor the enzymatic activity of enantioselective methionine sulfoxide reductase.
ER  -

POLJAK, Michal, Lucie WOHLRABOVA, Eduardo PALAO UTIEL, Jela NOCIAROVÁ, Jiri MISEK, Tomáš SLANINA a Petr KLÁN. Chalcogen-based ratiometric reversible BODIPY redox sensors for the determination of enantioselective methionine sulfoxide reductase activity. \textit{Chemical Communications}. Royal Society of Chemistry, 2022, roč.~58, č.~44, s.~6389-6392. ISSN~1359-7345. Dostupné z: https://dx.doi.org/10.1039/d2cc02016e.

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