Coupling BODIPY with nitrogen-doped graphene quantum dots to
address the water solubility of photosensitizers

J 2022

Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers

GOMEZ PEREZ, Inmaculada Jennifer, Marina RUSSO, Orazio Angelo ARCIDIACONO, Esther Maria MARQUEZ SANCHEZ - CARNERERO, Petr KLÁN et. al.

Základní údaje

Originální název

Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers

Autoři

GOMEZ PEREZ, Inmaculada Jennifer (724 Španělsko, garant, domácí), Marina RUSSO (380 Itálie, domácí), Orazio Angelo ARCIDIACONO (380 Itálie, domácí), Esther Maria MARQUEZ SANCHEZ - CARNERERO (724 Španělsko, domácí), Petr KLÁN (203 Česká republika, domácí) a Lenka ZAJÍČKOVÁ (203 Česká republika, domácí)

Vydání

Materials Chemistry Frontiers, Cambridge, Royal Society of Chemistry, 2022, 2052-1537

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10400 1.4 Chemical sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.000

Kód RIV

RIV/00216224:14310/22:00126190

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1039/d2qm00200k

UT WoS

000802645400001

Klíčová slova anglicky

SINGLET OXYGEN GENERATION; PHOTODYNAMIC THERAPY; CARBON DOTS; NANOPARTICLES; DERIVATIVES; MECHANISMS; MOLECULES

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 3. 2023 22:45, doc. Mgr. Lenka Zajíčková, Ph.D.

Anotace

V originále

The potential of photodynamic therapy (PDT) applications is based primarily on the selection of suitable photosensitizers (PSs). However, highly efficient PSs producing singlet oxygen and other reactive oxygen species (ROS) often have poor water solubility and tend to aggregate in biological media. The most common alternative strategy to address the solubility of PSs is based on difficult-to-control encapsulation or conjugation to liposomes, micelles, or other nanoparticles via surface non-covalent interactions. Covalent functionalization remains relatively unexplored for common PSs. Here, we report a strategy to use highly efficient but poorly water-soluble BODIPY PSs connected to the surface of nitrogen-doped graphene quantum dots (NGQDs) through controlled covalent functionalization. These NGQD-BODIPY PSs do not aggregate in aqueous solutions and generate ROS upon irradiation with visible light, with singlet-oxygen production quantum yields up to 83%. In vitro fluorescence bioimaging was used to confirm that the PSs reside mostly in the cytoplasmic region of human cervical cancer cells (HeLa), and the system reduced the cell viability by similar to 85% upon irradiation.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

EF20_079/0017045, projekt VaV

Název: MSCAfellow4@MUNI

LM2018121, projekt VaV

Název: Výzkumná infrastruktura RECETOX (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90110, velká výzkumná infrastruktura

Název: CzechNanoLab

Citovat

GOMEZ PEREZ, Inmaculada Jennifer, Marina RUSSO, Orazio Angelo ARCIDIACONO, Esther Maria MARQUEZ SANCHEZ - CARNERERO, Petr KLÁN a Lenka ZAJÍČKOVÁ. Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers. Materials Chemistry Frontiers. Cambridge: Royal Society of Chemistry, 2022, roč. 6, č. 12, s. 1719-1726. ISSN 2052-1537. Dostupné z: https://dx.doi.org/10.1039/d2qm00200k.

@article{1863799,
   author = {Gomez Perez, Inmaculada Jennifer and Russo, Marina and Arcidiacono, Orazio Angelo and Marquez Sanchez and Carnerero, Esther Maria and Klán, Petr and Zajíčková, Lenka},
   article_location = {Cambridge},
   article_number = {12},
   doi = {http://dx.doi.org/10.1039/d2qm00200k},
   keywords = {SINGLET OXYGEN GENERATION; PHOTODYNAMIC THERAPY; CARBON DOTS; NANOPARTICLES; DERIVATIVES; MECHANISMS; MOLECULES},
   language = {eng},
   issn = {2052-1537},
   journal = {Materials Chemistry Frontiers},
   title = {Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers},
   url = {https://pubs.rsc.org/en/content/articlelanding/2022/QM/D2QM00200K},
   volume = {6},
   year = {2022}
}

TY  - JOUR
ID  - 1863799
AU  - Gomez Perez, Inmaculada Jennifer - Russo, Marina - Arcidiacono, Orazio Angelo - Marquez Sanchez - Carnerero, Esther Maria - Klán, Petr - Zajíčková, Lenka
PY  - 2022
TI  - Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers
JF  - Materials Chemistry Frontiers
VL  - 6
IS  - 12
SP  - 1719-1726
EP  - 1719-1726
PB  - Royal Society of Chemistry
SN  - 20521537
KW  - SINGLET OXYGEN GENERATION
KW  - PHOTODYNAMIC THERAPY
KW  - CARBON DOTS
KW  - NANOPARTICLES
KW  - DERIVATIVES
KW  - MECHANISMS
KW  - MOLECULES
UR  - https://pubs.rsc.org/en/content/articlelanding/2022/QM/D2QM00200K
N2  - The potential of photodynamic therapy (PDT) applications is based primarily on the selection of suitable photosensitizers (PSs). However, highly efficient PSs producing singlet oxygen and other reactive oxygen species (ROS) often have poor water solubility and tend to aggregate in biological media. The most common alternative strategy to address the solubility of PSs is based on difficult-to-control encapsulation or conjugation to liposomes, micelles, or other nanoparticles via surface non-covalent interactions. Covalent functionalization remains relatively unexplored for common PSs. Here, we report a strategy to use highly efficient but poorly water-soluble BODIPY PSs connected to the surface of nitrogen-doped graphene quantum dots (NGQDs) through controlled covalent functionalization. These NGQD-BODIPY PSs do not aggregate in aqueous solutions and generate ROS upon irradiation with visible light, with singlet-oxygen production quantum yields up to 83%. In vitro fluorescence bioimaging was used to confirm that the PSs reside mostly in the cytoplasmic region of human cervical cancer cells (HeLa), and the system reduced the cell viability by similar to 85% upon irradiation.
ER  -

GOMEZ PEREZ, Inmaculada Jennifer, Marina RUSSO, Orazio Angelo ARCIDIACONO, Esther Maria MARQUEZ SANCHEZ - CARNERERO, Petr KLÁN a Lenka ZAJÍČKOVÁ. Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers. \textit{Materials Chemistry Frontiers}. Cambridge: Royal Society of Chemistry, 2022, roč.~6, č.~12, s.~1719-1726. ISSN~2052-1537. Dostupné z: https://dx.doi.org/10.1039/d2qm00200k.

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