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@article{1863799, author = {Gomez Perez, Inmaculada Jennifer and Russo, Marina and Arcidiacono, Orazio Angelo and Marquez Sanchez and Carnerero, Esther Maria and Klán, Petr and Zajíčková, Lenka}, article_location = {Cambridge}, article_number = {12}, doi = {http://dx.doi.org/10.1039/d2qm00200k}, keywords = {SINGLET OXYGEN GENERATION; PHOTODYNAMIC THERAPY; CARBON DOTS; NANOPARTICLES; DERIVATIVES; MECHANISMS; MOLECULES}, language = {eng}, issn = {2052-1537}, journal = {Materials Chemistry Frontiers}, title = {Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers}, url = {https://pubs.rsc.org/en/content/articlelanding/2022/QM/D2QM00200K}, volume = {6}, year = {2022} }
TY - JOUR ID - 1863799 AU - Gomez Perez, Inmaculada Jennifer - Russo, Marina - Arcidiacono, Orazio Angelo - Marquez Sanchez - Carnerero, Esther Maria - Klán, Petr - Zajíčková, Lenka PY - 2022 TI - Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers JF - Materials Chemistry Frontiers VL - 6 IS - 12 SP - 1719-1726 EP - 1719-1726 PB - Royal Society of Chemistry SN - 20521537 KW - SINGLET OXYGEN GENERATION KW - PHOTODYNAMIC THERAPY KW - CARBON DOTS KW - NANOPARTICLES KW - DERIVATIVES KW - MECHANISMS KW - MOLECULES UR - https://pubs.rsc.org/en/content/articlelanding/2022/QM/D2QM00200K N2 - The potential of photodynamic therapy (PDT) applications is based primarily on the selection of suitable photosensitizers (PSs). However, highly efficient PSs producing singlet oxygen and other reactive oxygen species (ROS) often have poor water solubility and tend to aggregate in biological media. The most common alternative strategy to address the solubility of PSs is based on difficult-to-control encapsulation or conjugation to liposomes, micelles, or other nanoparticles via surface non-covalent interactions. Covalent functionalization remains relatively unexplored for common PSs. Here, we report a strategy to use highly efficient but poorly water-soluble BODIPY PSs connected to the surface of nitrogen-doped graphene quantum dots (NGQDs) through controlled covalent functionalization. These NGQD-BODIPY PSs do not aggregate in aqueous solutions and generate ROS upon irradiation with visible light, with singlet-oxygen production quantum yields up to 83%. In vitro fluorescence bioimaging was used to confirm that the PSs reside mostly in the cytoplasmic region of human cervical cancer cells (HeLa), and the system reduced the cell viability by similar to 85% upon irradiation. ER -
GOMEZ PEREZ, Inmaculada Jennifer, Marina RUSSO, Orazio Angelo ARCIDIACONO, Esther Maria MARQUEZ SANCHEZ - CARNERERO, Petr KLÁN a Lenka ZAJÍČKOVÁ. Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers. \textit{Materials Chemistry Frontiers}. Cambridge: Royal Society of Chemistry, 2022, roč.~6, č.~12, s.~1719-1726. ISSN~2052-1537. Dostupné z: https://dx.doi.org/10.1039/d2qm00200k.
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