A High-Risk Profile for Invasive Fungal Infections Is
Associated with Altered Nasal Microbiota and Niche Determinants

J 2022

A High-Risk Profile for Invasive Fungal Infections Is Associated with Altered Nasal Microbiota and Niche Determinants

COSTANTINI, C., E. NUNZI, A. SPOLZINO, F. MERLI, L. FACCHINI et. al.

Základní údaje

Originální název

A High-Risk Profile for Invasive Fungal Infections Is Associated with Altered Nasal Microbiota and Niche Determinants

Autoři

COSTANTINI, C., E. NUNZI, A. SPOLZINO, F. MERLI, L. FACCHINI, A. SPADEA, L. MELILLO, K. CODELUPPI, F. MARCHESI, G. MARCHESINI, D. VALENTE, G. DRAGONETTI, G. NADALI, Lukas ENGLMAIER, Kateřina COUFALÍKOVÁ (203 Česká republika, domácí), Zdeněk SPÁČIL (203 Česká republika, garant, domácí), M.M. BELLET, M. PARIANO, G. RENGA, C. STINCARDINI, F. D'ONOFRIO, S. BOZZA, L. PAGANO, F. AVERSA a L. ROMANI

Vydání

INFECTION AND IMMUNITY, WASHINGTON, American Society for Microbiology, 2022, 0019-9567

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.100

Kód RIV

RIV/00216224:14310/22:00126195

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1128/iai.00048-22

UT WoS

000786356100013

Klíčová slova anglicky

hematological malignancies; invasive fungal infection; nasal microbiome; tryptophan; kynurenine; tolerance

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 7. 2022 21:43, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

It is becoming increasingly clear that the communities of microorganisms that populate the surfaces exposed to the external environment, termed microbiota, are key players in the regulation of pathogen-host cross talk affecting the onset as well as the outcome of infectious diseases. We have performed a multicenter, prospective, observational study in which nasal and oropharyngeal swabs were collected for microbiota predicting the risk of invasive fungal infections (IFIs) in patients with hematological malignancies. Here, we demonstrate that the nasal and oropharyngeal microbiota are different, although similar characteristics differentiate high-risk from low-risk samples at both sites. Indeed, similar to previously published results on the oropharyngeal microbiota, high-risk samples in the nose were characterized by low diversity, a loss of beneficial bacteria, and an expansion of potentially pathogenic taxa, in the presence of reduced levels of tryptophan (Trp). At variance with oropharyngeal samples, however, low Trp levels were associated with defective host-derived kynurenine production, suggesting reduced tolerance mechanisms at the nasal mucosal surface. This was accompanied by reduced levels of the chemokine interleukin-8 (IL-8), likely associated with a reduced recruitment of neutrophils and impaired fungal clearance. Thus, the nasal and pharyngeal microbiomes of hematological patients provide complementary information that could improve predictive tools for the risk of IFI in hematological patients.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

GJ17-24592Y, projekt VaV

Název: Mapování interakcí mezi základními metabolickými pochody a střevní mikroflórou

Investor: Grantová agentura ČR, Mapování interakcí mezi základními metabolickými pochody a střevní mikroflórou

LM2018121, projekt VaV

Název: Výzkumná infrastruktura RECETOX (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

Citovat

COSTANTINI, C., E. NUNZI, A. SPOLZINO, F. MERLI, L. FACCHINI, A. SPADEA, L. MELILLO, K. CODELUPPI, F. MARCHESI, G. MARCHESINI, D. VALENTE, G. DRAGONETTI, G. NADALI, Lukas ENGLMAIER, Kateřina COUFALÍKOVÁ, Zdeněk SPÁČIL, M.M. BELLET, M. PARIANO, G. RENGA, C. STINCARDINI, F. D'ONOFRIO, S. BOZZA, L. PAGANO, F. AVERSA a L. ROMANI. A High-Risk Profile for Invasive Fungal Infections Is Associated with Altered Nasal Microbiota and Niche Determinants. INFECTION AND IMMUNITY. WASHINGTON: American Society for Microbiology, 2022, roč. 90, č. 4, s. 1-14. ISSN 0019-9567. Dostupné z: https://dx.doi.org/10.1128/iai.00048-22.

@article{1863813,
   author = {Costantini, C. and Nunzi, E. and Spolzino, A. and Merli, F. and Facchini, L. and Spadea, A. and Melillo, L. and Codeluppi, K. and Marchesi, F. and Marchesini, G. and Valente, D. and Dragonetti, G. and Nadali, G. and Englmaier, Lukas and Coufalíková, Kateřina and Spáčil, Zdeněk and Bellet, M.M. and Pariano, M. and Renga, G. and Stincardini, C. and D'Onofrio, F. and Bozza, S. and Pagano, L. and Aversa, F. and Romani, L.},
   article_location = {WASHINGTON},
   article_number = {4},
   doi = {http://dx.doi.org/10.1128/iai.00048-22},
   keywords = {hematological malignancies; invasive fungal infection; nasal microbiome; tryptophan; kynurenine; tolerance},
   language = {eng},
   issn = {0019-9567},
   journal = {INFECTION AND IMMUNITY},
   title = {A High-Risk Profile for Invasive Fungal Infections Is Associated with Altered Nasal Microbiota and Niche Determinants},
   url = {https://journals.asm.org/doi/10.1128/iai.00048-22},
   volume = {90},
   year = {2022}
}

TY  - JOUR
ID  - 1863813
AU  - Costantini, C. - Nunzi, E. - Spolzino, A. - Merli, F. - Facchini, L. - Spadea, A. - Melillo, L. - Codeluppi, K. - Marchesi, F. - Marchesini, G. - Valente, D. - Dragonetti, G. - Nadali, G. - Englmaier, Lukas - Coufalíková, Kateřina - Spáčil, Zdeněk - Bellet, M.M. - Pariano, M. - Renga, G. - Stincardini, C. - D'Onofrio, F. - Bozza, S. - Pagano, L. - Aversa, F. - Romani, L.
PY  - 2022
TI  - A High-Risk Profile for Invasive Fungal Infections Is Associated with Altered Nasal Microbiota and Niche Determinants
JF  - INFECTION AND IMMUNITY
VL  - 90
IS  - 4
SP  - 1-14
EP  - 1-14
PB  - American Society for Microbiology
SN  - 00199567
KW  - hematological malignancies
KW  - invasive fungal infection
KW  - nasal microbiome
KW  - tryptophan
KW  - kynurenine
KW  - tolerance
UR  - https://journals.asm.org/doi/10.1128/iai.00048-22
N2  - It is becoming increasingly clear that the communities of microorganisms that populate the surfaces exposed to the external environment, termed microbiota, are key players in the regulation of pathogen-host cross talk affecting the onset as well as the outcome of infectious diseases. We have performed a multicenter, prospective, observational study in which nasal and oropharyngeal swabs were collected for microbiota predicting the risk of invasive fungal infections (IFIs) in patients with hematological malignancies. Here, we demonstrate that the nasal and oropharyngeal microbiota are different, although similar characteristics differentiate high-risk from low-risk samples at both sites. Indeed, similar to previously published results on the oropharyngeal microbiota, high-risk samples in the nose were characterized by low diversity, a loss of beneficial bacteria, and an expansion of potentially pathogenic taxa, in the presence of reduced levels of tryptophan (Trp). At variance with oropharyngeal samples, however, low Trp levels were associated with defective host-derived kynurenine production, suggesting reduced tolerance mechanisms at the nasal mucosal surface. This was accompanied by reduced levels of the chemokine interleukin-8 (IL-8), likely associated with a reduced recruitment of neutrophils and impaired fungal clearance. Thus, the nasal and pharyngeal microbiomes of hematological patients provide complementary information that could improve predictive tools for the risk of IFI in hematological patients.
ER  -

COSTANTINI, C., E. NUNZI, A. SPOLZINO, F. MERLI, L. FACCHINI, A. SPADEA, L. MELILLO, K. CODELUPPI, F. MARCHESI, G. MARCHESINI, D. VALENTE, G. DRAGONETTI, G. NADALI, Lukas ENGLMAIER, Kateřina COUFALÍKOVÁ, Zdeněk SPÁČIL, M.M. BELLET, M. PARIANO, G. RENGA, C. STINCARDINI, F. D'ONOFRIO, S. BOZZA, L. PAGANO, F. AVERSA a L. ROMANI. A High-Risk Profile for Invasive Fungal Infections Is Associated with Altered Nasal Microbiota and Niche Determinants. \textit{INFECTION AND IMMUNITY}. WASHINGTON: American Society for Microbiology, 2022, roč.~90, č.~4, s.~1-14. ISSN~0019-9567. Dostupné z: https://dx.doi.org/10.1128/iai.00048-22.

Podrobný výpis o publikaci