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@article{1874687,
author = {Šmíd, Martin and Berec, Luděk and Přibylová, Lenka and Májek, Ondřej and Pavlík, Tomáš and Jarkovský, Jiří and Weiner, Jakub and Barusová, Tamara and Trnka, Jan},
article_number = {8},
doi = {http://dx.doi.org/10.1093/infdis/jiac161},
keywords = {COVID-19; postinfection immunity; vaccine effectiveness; SARS-CoV-2; Omicron variant; hospitalization},
language = {eng},
issn = {0022-1899},
journal = {The Journal of Infectious Diseases},
title = {Protection by Vaccines and Previous Infection Against the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2},
url = {https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiac161/6575414?login=true},
volume = {226},
year = {2022}
}
TY - JOUR
ID - 1874687
AU - Šmíd, Martin - Berec, Luděk - Přibylová, Lenka - Májek, Ondřej - Pavlík, Tomáš - Jarkovský, Jiří - Weiner, Jakub - Barusová, Tamara - Trnka, Jan
PY - 2022
TI - Protection by Vaccines and Previous Infection Against the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2
JF - The Journal of Infectious Diseases
VL - 226
IS - 8
SP - 1385-1390
EP - 1385-1390
PB - Oxford University Press
SN - 00221899
KW - COVID-19
KW - postinfection immunity
KW - vaccine effectiveness
KW - SARS-CoV-2
KW - Omicron variant
KW - hospitalization
UR - https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiac161/6575414?login=true
N2 - Background The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades immunity conferred by vaccines and previous infections. Methods We used a Cox proportional hazards model and a logistic regression on individual-level population-wide data from the Czech Republic to estimate risks of infection and hospitalization, including severe states. Results A recent (≤2 months) full vaccination reached vaccine effectiveness (VE) of 43% (95% confidence interval [CI], 42%–44%) against infection by Omicron compared to 73% (95% CI, 72%–74%) against Delta. A recent booster increased VE to 56% (95% CI, 55%–56%) against Omicron infection compared to 90% (95% CI, 90%–91%) for Delta. The VE against Omicron hospitalization of a recent full vaccination was 45% (95% 95% CI, 29%–57%), with a recent booster 87% (95% CI, 84%–88%). The VE against the need for oxygen therapy due to Omicron was 57% (95% CI, 32%–72%) for recent vaccination, 90% (95% CI, 87%–92%) for a recent booster. Postinfection protection against Omicron hospitalization declined from 68% (95% CI, 68%–69%) at ≤6 months to 13% (95% CI, 11%–14%) at >6 months after a previous infection. The odds ratios for Omicron relative to Delta were 0.36 (95% CI, .34–.38) for hospitalization, 0.24 (95% CI, .22–.26) for oxygen, and 0.24 (95% CI, .21–.28) for intensive care unit admission. Conclusions Recent vaccination still brings substantial protection against severe outcome for Omicron.
ER -
ŠMÍD, Martin, Luděk BEREC, Lenka PŘIBYLOVÁ, Ondřej MÁJEK, Tomáš PAVLÍK, Jiří JARKOVSKÝ, Jakub WEINER, Tamara BARUSOVÁ a Jan TRNKA. Protection by Vaccines and Previous Infection Against the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2. \textit{The Journal of Infectious Diseases}. Oxford University Press, 2022, roč.~226, č.~8, s.~1385-1390. ISSN~0022-1899. Dostupné z: https://dx.doi.org/10.1093/infdis/jiac161.
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