Late effects of childhood cancer recorded at a single
outpatient clinic over the course of one year: implications for
the follow-up care

J 2022

Late effects of childhood cancer recorded at a single outpatient clinic over the course of one year: implications for the follow-up care

KEPÁK, Tomáš, Hana HRSTKOVÁ, Viera BAJČIOVÁ, Vítězslav DUŠEK, Marta HOLÍKOVÁ et. al.

Základní údaje

Originální název

Late effects of childhood cancer recorded at a single outpatient clinic over the course of one year: implications for the follow-up care

Autoři

KEPÁK, Tomáš (203 Česká republika, domácí), Hana HRSTKOVÁ (203 Česká republika, domácí), Viera BAJČIOVÁ (703 Slovensko, domácí), Vítězslav DUŠEK (203 Česká republika, domácí), Marta HOLÍKOVÁ (203 Česká republika), Lucie ŠTRUBLOVÁ (203 Česká republika, domácí) a Kateřina KEPÁKOVÁ (203 Česká republika, domácí)

Vydání

NEOPLASMA, BRATISLAVA, AEPRESS SRO, 2022, 0028-2685

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.000

Kód RIV

RIV/00216224:14110/22:00126281

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.4149/neo_2022_220531N584

UT WoS

001015362100023

Klíčová slova anglicky

late effects of childhood cancer; follow-up care; personalized care; mental health; cancer survivorship

Štítky

14110321, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 8. 2023 11:59, Mgr. Tereza Miškechová

Anotace

V originále

Systematic registration and analysis of detailed treatment data and data on late effects in survivors of childhood cancer are important both for building the evidence base for future assessment of current innovative therapies in pediatric oncology and for personalization of preventive care for survivors of childhood cancer. The paper provides a descriptive analysis of medical data (diagnosis, treatment, late effects, and health status) and selected patient-reported outcomes (mental health and psychosocial well-being) from a study group of 133 survivors of childhood cancer. We recruited for the study a consecutive series of survivors who attended an outpatient Late Effects Clinic at St. Anne's University Hospital in Brno, Czech Republic for a follow-up appointment over the course of one year (between March 2021 and February 2022) and met the study criteria. The enrolled survivors had been diagnosed with childhood cancer in the period 1979-2016. The average age in the sample was 27.9 years (18-53 years). We extracted and categorized the participants’ treatment data and data on relevant health outcomes, both somatic and mental, from the medical records. Patient-reported outcomes were measured using the clinic’s questionnaires completed by survivors prior to medical examination at the clinic. The most frequent adverse health outcome in the study sample - found in half of the survivors (50%) was dyslipidemia (hypercholesterolemia and/or hypertriglyceridemia). Almost the same proportion of survivors were overweight (45%), another 15% were obese and two survivors (1.5%) were even morbidly obese. Endocrinopathies were observed in more than one third (35.3%) of the survivors, followed by nephropathy seen in another third (33.8%). Among other identified health outcomes were cardiovascular abnormalities (found in 9.7% of survivors) and fertility impairment (9%). More than one-third (38%) reported chronic fatigue and as many as one-half (51%) reported pain. Mobility problems were admitted by 20% of the cohort. A remarkably high percentage of survivors (70%) communicated some level of mental-health issues. Moderate to severe anxiety and/or depression was reported by 25% of survivors. 40% of survivors experienced strong fears of disease recurrence, another 40% reported mild or moderate fears. Fear of late effects was communicated by 83% of survivors, with 38% experiencing high levels of concerns. Only 8% of survivors had no adverse health outcome. The rate of somatic health outcomes identified in our sample is high, yet broadly in line with expectations and published literature. There is a major discrepancy between the (very high) frequency of self-reported mental-health issues and corresponding records of mental-health issues in medical files (very few). Some of the most frequent somatic health outcomes are important modifiable risk factors for the development of a number of major diseases such as heart disease and stroke, high blood pressure, diabetes, and some cancers. The identified somatic and psychological health outcomes are mutually interconnected and alterable and highlight the need for patient education on healthy lifestyle. There is a clear need for improved psychological support for childhood cancer survivors, including mitigation of unnecessary anxieties resulting from unsubstantiated health concerns by disseminating positive messages.

Návaznosti

MUNI/A/1391/2021, interní kód MU

Název: Molekulární, buněčná, tkáňová a systémová patofyziologie vybraných komplexních nemocí (Akronym: KOMPLEX_PF)

Investor: Masarykova univerzita, Molekulární, buněčná, tkáňová a systémová patofyziologie vybraných komplexních nemocí

Citovat

KEPÁK, Tomáš, Hana HRSTKOVÁ, Viera BAJČIOVÁ, Vítězslav DUŠEK, Marta HOLÍKOVÁ, Lucie ŠTRUBLOVÁ a Kateřina KEPÁKOVÁ. Late effects of childhood cancer recorded at a single outpatient clinic over the course of one year: implications for the follow-up care. NEOPLASMA. BRATISLAVA: AEPRESS SRO, 2022, roč. 69, č. 4, s. 983-992. ISSN 0028-2685. Dostupné z: https://dx.doi.org/10.4149/neo_2022_220531N584.

@article{1875234,
   author = {Kepák, Tomáš and Hrstková, Hana and Bajčiová, Viera and Dušek, Vítězslav and Holíková, Marta and Štrublová, Lucie and Kepáková, Kateřina},
   article_location = {BRATISLAVA},
   article_number = {4},
   doi = {http://dx.doi.org/10.4149/neo_2022_220531N584},
   keywords = {late effects of childhood cancer; follow-up care; personalized care; mental health; cancer survivorship},
   language = {eng},
   issn = {0028-2685},
   journal = {NEOPLASMA},
   title = {Late effects of childhood cancer recorded at a single outpatient clinic over the course of one year: implications for the follow-up care},
   url = {http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7731&category_id=180&option=com_virtuemart&vmcchk=1&Itemid=1},
   volume = {69},
   year = {2022}
}

TY  - JOUR
ID  - 1875234
AU  - Kepák, Tomáš - Hrstková, Hana - Bajčiová, Viera - Dušek, Vítězslav - Holíková, Marta - Štrublová, Lucie - Kepáková, Kateřina
PY  - 2022
TI  - Late effects of childhood cancer recorded at a single outpatient clinic over the course of one year: implications for the follow-up care
JF  - NEOPLASMA
VL  - 69
IS  - 4
SP  - 983-992
EP  - 983-992
PB  - AEPRESS SRO
SN  - 00282685
KW  - late effects of childhood cancer
KW  - follow-up care
KW  - personalized care
KW  - mental health
KW  - cancer survivorship
UR  - http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7731&category_id=180&option=com_virtuemart&vmcchk=1&Itemid=1
N2  - Systematic registration and analysis of detailed treatment data and data on late effects in survivors of childhood cancer are important both for building the evidence base for future assessment of current innovative therapies in pediatric oncology and for personalization of preventive care for survivors of childhood cancer. The paper provides a descriptive analysis of medical data (diagnosis, treatment, late effects, and health status) and selected patient-reported outcomes (mental health and psychosocial well-being) from a study group of 133 survivors of childhood cancer. We recruited for the study a consecutive series of survivors who attended an outpatient Late Effects Clinic at St. Anne's University Hospital in Brno, Czech Republic for a follow-up appointment over the course of one year (between March 2021 and February 2022) and met the study criteria. The enrolled survivors had been diagnosed with childhood cancer in the period 1979-2016. The average age in the sample was 27.9 years (18-53 years). We extracted and categorized the participants’ treatment data and data on relevant health outcomes, both somatic and mental, from the medical records. Patient-reported outcomes were measured using the clinic’s questionnaires completed by survivors prior to medical examination at the clinic. The most frequent adverse health outcome in the study sample - found in half of the survivors (50%) was dyslipidemia (hypercholesterolemia and/or hypertriglyceridemia). Almost the same proportion of survivors were overweight (45%), another 15% were obese and two survivors (1.5%) were even morbidly obese. Endocrinopathies were observed in more than one third (35.3%) of the survivors, followed by nephropathy seen in another third (33.8%). Among other identified health outcomes were cardiovascular abnormalities (found in 9.7% of survivors) and fertility impairment (9%). More than one-third (38%) reported chronic fatigue and as many as one-half (51%) reported pain. Mobility problems were admitted by 20% of the cohort. A remarkably high percentage of survivors (70%) communicated some level of mental-health issues. Moderate to severe anxiety and/or depression was reported by 25% of survivors. 40% of survivors experienced strong fears of disease recurrence, another 40% reported mild or moderate fears. Fear of late effects was communicated by 83% of survivors, with 38% experiencing high levels of concerns. Only 8% of survivors had no adverse health outcome. The rate of somatic health outcomes identified in our sample is high, yet broadly in line with expectations and published literature. There is a major discrepancy between the (very high) frequency of self-reported mental-health issues and corresponding records of mental-health issues in medical files (very few). Some of the most frequent somatic health outcomes are important modifiable risk factors for the development of a number of major diseases such as heart disease and stroke, high blood pressure, diabetes, and some cancers. The identified somatic and psychological health outcomes are mutually interconnected and alterable and highlight the need for patient education on healthy lifestyle. There is a clear need for improved psychological support for childhood cancer survivors, including mitigation of unnecessary anxieties resulting from unsubstantiated health concerns by disseminating positive messages.
ER  -

KEPÁK, Tomáš, Hana HRSTKOVÁ, Viera BAJČIOVÁ, Vítězslav DUŠEK, Marta HOLÍKOVÁ, Lucie ŠTRUBLOVÁ a Kateřina KEPÁKOVÁ. Late effects of childhood cancer recorded at a single outpatient clinic over the course of one year: implications for the follow-up care. \textit{NEOPLASMA}. BRATISLAVA: AEPRESS SRO, 2022, roč.~69, č.~4, s.~983-992. ISSN~0028-2685. Dostupné z: https://dx.doi.org/10.4149/neo\_{}2022\_{}220531N584.

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