2021
STUDY OF THE EFFECT OF PARACETAMOL BINDED IN POLYMERIC NANOPARTICLES ON DAFNIA MAGNA
HAVELKOVA, Barbora, Karel SEHNAL, Dominik BANÁŠ, Marta KEPINSKA, Branislav RUTTKAY-NEDECKÝ et. al.Základní údaje
Originální název
STUDY OF THE EFFECT OF PARACETAMOL BINDED IN POLYMERIC NANOPARTICLES ON DAFNIA MAGNA
Autoři
HAVELKOVA, Barbora, Karel SEHNAL (203 Česká republika, domácí), Dominik BANÁŠ (703 Slovensko, domácí), Marta KEPINSKA, Branislav RUTTKAY-NEDECKÝ (203 Česká republika, domácí), Martina STANKOVA, Carlos FERNANDEZ, Miroslava BEKLOVA a René KIZEK (203 Česká republika)
Vydání
Ostrava, Proceedings 12th International Conference on Nanomaterials - Research & Application, od s. 318-323, 6 s. 2021
Nakladatel
TANGER LTD
Další údaje
Jazyk
angličtina
Typ výsledku
Stať ve sborníku
Obor
30104 Pharmacology and pharmacy
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Forma vydání
tištěná verze "print"
Odkazy
Kód RIV
RIV/00216224:14160/21:00129821
Organizační jednotka
Farmaceutická fakulta
ISBN
978-80-87294-98-7
ISSN
UT WoS
000664505500054
Klíčová slova anglicky
Ecotoxicology; chemical and biochemical analysis; nanomedicine
Změněno: 3. 8. 2023 10:41, JUDr. Sabina Krejčiříková
Anotace
V originále
Drugs are important xenobiotics in the environment. Their use increases with the growth of the human population, but also in agricultural primary production. Paracetamol (PAR) is a widely used analgesic and antipyretic and its production is still growing. Commonly available drug production technologies are being developed very intensively with nanotechnological modifications for their gradual and targeted release. Nanoparticles (ST/PAR) from starch were prepared: PAR (0, 1, 2, 3, 5 and 10 mg/L) was mixed with citric acid ester in a 1:8 v/v ratio for 30 min at 25 degrees C. By the centrifugation (16.000 g, 30 min) ST/PAR were obtained in the pellet. The effect of PAR was studied on Daphnia magna Straus (Cladocera, Crustacea). Adult females (70-400 mg) were used for self-evaluation. The EC50 was 3.749 mg/L after 48 h of PAR treatment. Total protein values determined by Lowry method were between 0.5-2.2 mg/mL and by Bradford method between 190-676 mg/L. Antioxidant activity values determined by CUPRAC method were between 4-15 mu g/mL GAE and by ABTS method ranged between 40-103 mu g/mL GAE. PAR values were between 9-40 mu M. Subsequently, the biological activity of the prepared nanoparticles was tested.