Protection provided by vaccination, booster doses and previous
infection against covid-19 infection, hospitalisation or death
over time in Czechia

J 2022

Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia

BEREC, Luděk, Martin ŠMÍD, Lenka PŘIBYLOVÁ, Ondřej MÁJEK, Tomáš PAVLÍK et. al.

Základní údaje

Originální název

Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia

Autoři

BEREC, Luděk (garant), Martin ŠMÍD, Lenka PŘIBYLOVÁ (203 Česká republika, domácí), Ondřej MÁJEK (203 Česká republika, domácí), Tomáš PAVLÍK (203 Česká republika, domácí), Jiří JARKOVSKÝ (203 Česká republika, domácí), Milan ZAJÍČEK, Jakub WEINER, Tamara BARUSOVÁ a Jan TRNKA

Vydání

PLoS ONE, Public Library of Science, 2022, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30303 Infectious Diseases

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.700

Kód RIV

RIV/00216224:14110/22:00126311

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1371/journal.pone.0270801

UT WoS

000844536800079

Klíčová slova anglicky

COVID 19; SARS CoV 2; Viral vaccines; Vaccines; Czech Republic; Immunity; Vaccination and immunization; Booster doses

Štítky

14119612, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 1. 2023 11:16, Mgr. Marie Šípková, DiS.

Anotace

V originále

Studies demonstrating the waning of post-vaccination and post-infection immunity against covid-19 generally analyzed a limited range of vaccines or subsets of populations. Using Czech national health data from the beginning of the covid-19 pandemic till November 20, 2021 we estimated the risks of reinfection, breakthrough infection, hospitalization and death by a Cox regression adjusted for sex, age, vaccine type and vaccination status. Vaccine effectiveness against infection declined from 87% at 0-2 months after the second dose to 53% at 7-8 months for BNT162b2 vaccine, from 90% at 0-2 months to 65% at 7-8 months for mRNA-1273, and from 83% at 0-2 months to 55% at 5-6 months for the ChAdOx1-S. Effectiveness against hospitalization and deaths declined by about 15% and 10%, respectively, during the first 6-8 months. Boosters (third dose) returned the protection to the levels observed shortly after dose 2. In unvaccinated, previously infected individuals the protection against infection declined from 97% after 2 months to 72% at 18 months. Our results confirm the waning of vaccination-induced immunity against infection and a smaller decline in the protection against hospitalization and death. Boosting restores the original vaccine effectiveness. Post-infection immunity also decreases over time.

Citovat

BEREC, Luděk, Martin ŠMÍD, Lenka PŘIBYLOVÁ, Ondřej MÁJEK, Tomáš PAVLÍK, Jiří JARKOVSKÝ, Milan ZAJÍČEK, Jakub WEINER, Tamara BARUSOVÁ a Jan TRNKA. Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia. PLoS ONE. Public Library of Science, 2022, roč. 17, č. 7, s. 1-13. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0270801.

@article{1876015,
   author = {Berec, Luděk and Šmíd, Martin and Přibylová, Lenka and Májek, Ondřej and Pavlík, Tomáš and Jarkovský, Jiří and Zajíček, Milan and Weiner, Jakub and Barusová, Tamara and Trnka, Jan},
   article_number = {7},
   doi = {http://dx.doi.org/10.1371/journal.pone.0270801},
   keywords = {COVID 19; SARS CoV 2; Viral vaccines; Vaccines; Czech Republic; Immunity; Vaccination and immunization; Booster doses},
   language = {eng},
   issn = {1932-6203},
   journal = {PLoS ONE},
   title = {Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia},
   url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0270801},
   volume = {17},
   year = {2022}
}

TY  - JOUR
ID  - 1876015
AU  - Berec, Luděk - Šmíd, Martin - Přibylová, Lenka - Májek, Ondřej - Pavlík, Tomáš - Jarkovský, Jiří - Zajíček, Milan - Weiner, Jakub - Barusová, Tamara - Trnka, Jan
PY  - 2022
TI  - Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia
JF  - PLoS ONE
VL  - 17
IS  - 7
SP  - 1-13
EP  - 1-13
PB  - Public Library of Science
SN  - 19326203
KW  - COVID 19
KW  - SARS CoV 2
KW  - Viral vaccines
KW  - Vaccines
KW  - Czech Republic
KW  - Immunity
KW  - Vaccination and immunization
KW  - Booster doses
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0270801
N2  - Studies demonstrating the waning of post-vaccination and post-infection immunity against covid-19 generally analyzed a limited range of vaccines or subsets of populations. Using Czech national health data from the beginning of the covid-19 pandemic till November 20, 2021 we estimated the risks of reinfection, breakthrough infection, hospitalization and death by a Cox regression adjusted for sex, age, vaccine type and vaccination status. Vaccine effectiveness against infection declined from 87% at 0-2 months after the second dose to 53% at 7-8 months for BNT162b2 vaccine, from 90% at 0-2 months to 65% at 7-8 months for mRNA-1273, and from 83% at 0-2 months to 55% at 5-6 months for the ChAdOx1-S. Effectiveness against hospitalization and deaths declined by about 15% and 10%, respectively, during the first 6-8 months. Boosters (third dose) returned the protection to the levels observed shortly after dose 2. In unvaccinated, previously infected individuals the protection against infection declined from 97% after 2 months to 72% at 18 months. Our results confirm the waning of vaccination-induced immunity against infection and a smaller decline in the protection against hospitalization and death. Boosting restores the original vaccine effectiveness. Post-infection immunity also decreases over time.
ER  -

BEREC, Luděk, Martin ŠMÍD, Lenka PŘIBYLOVÁ, Ondřej MÁJEK, Tomáš PAVLÍK, Jiří JARKOVSKÝ, Milan ZAJÍČEK, Jakub WEINER, Tamara BARUSOVÁ a Jan TRNKA. Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia. \textit{PLoS ONE}. Public Library of Science, 2022, roč.~17, č.~7, s.~1-13. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0270801.

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