| KAMENEVA, Polina, Victoria I. MELNIKOVA, Maria Eleni KASTRITI, Anastasia KURTOVA, Emil KRYUKOV, Aliia MURTAZINA, Louis FAURE, Irina POVERENNAYA, Artem V. ARTEMOV, Tatiana S. KALININA, Nikita V. KUDRYASHOV, Michael BADER, Jan ŠKODA, Petr CHLAPEK, Lucie CURYLOVÁ, Lukáš SOURADA, Jakub NERADIL, Marketa TESAROVA, Massimo PASQUALETTI, Patricia GASPAR, Vasily D. YAKUSHOV, Boris I. SHEFTEL, Tomas ZIKMUND, Jozef KAISER, Kaj FRIED, Natalia ALENINA, Elena E. VORONEZHSKAYA a Igor ADAMEYKO. Serotonin limits generation of chromaffin cells during adrenal organ development. Nature Communications. Nature Publishing Group, 2022, roč. 13, č. 1, s. 1-21. ISSN 2041-1723. Dostupné z: https://dx.doi.org/10.1038/s41467-022-30438-w. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1876143,
author = {Kameneva, Polina and Melnikova, Victoria I. and Kastriti, Maria Eleni and Kurtova, Anastasia and Kryukov, Emil and Murtazina, Aliia and Faure, Louis and Poverennaya, Irina and Artemov, Artem V. and Kalinina, Tatiana S. and Kudryashov, Nikita V. and Bader, Michael and Škoda, Jan and Chlapek, Petr and Curylová, Lucie and Sourada, Lukáš and Neradil, Jakub and Tesarova, Marketa and Pasqualetti, Massimo and Gaspar, Patricia and Yakushov, Vasily D. and Sheftel, Boris I. and Zikmund, Tomas and Kaiser, Jozef and Fried, Kaj and Alenina, Natalia and Voronezhskaya, Elena E. and Adameyko, Igor},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41467-022-30438-w},
keywords = {serotonin; HTR3A; adrenal gland; neuroblastoma},
language = {eng},
issn = {2041-1723},
journal = {Nature Communications},
title = {Serotonin limits generation of chromaffin cells during adrenal organ development},
url = {https://www.nature.com/articles/s41467-022-30438-w},
volume = {13},
year = {2022}
}
TY - JOUR
ID - 1876143
AU - Kameneva, Polina - Melnikova, Victoria I. - Kastriti, Maria Eleni - Kurtova, Anastasia - Kryukov, Emil - Murtazina, Aliia - Faure, Louis - Poverennaya, Irina - Artemov, Artem V. - Kalinina, Tatiana S. - Kudryashov, Nikita V. - Bader, Michael - Škoda, Jan - Chlapek, Petr - Curylová, Lucie - Sourada, Lukáš - Neradil, Jakub - Tesarova, Marketa - Pasqualetti, Massimo - Gaspar, Patricia - Yakushov, Vasily D. - Sheftel, Boris I. - Zikmund, Tomas - Kaiser, Jozef - Fried, Kaj - Alenina, Natalia - Voronezhskaya, Elena E. - Adameyko, Igor
PY - 2022
TI - Serotonin limits generation of chromaffin cells during adrenal organ development
JF - Nature Communications
VL - 13
IS - 1
SP - 1-21
EP - 1-21
PB - Nature Publishing Group
SN - 20411723
KW - serotonin
KW - HTR3A
KW - adrenal gland
KW - neuroblastoma
UR - https://www.nature.com/articles/s41467-022-30438-w
N2 - Adrenal glands are the major organs releasing catecholamines and regulating our stress response. The mechanisms balancing generation of adrenergic chromaffin cells and protecting against neuroblastoma tumors are still enigmatic. Here we revealed that serotonin (5HT) controls the numbers of chromaffin cells by acting upon their immediate progenitor "bridge" cells via 5-hydroxytryptamine receptor 3A (HTR3A), and the aggressive HTR3A(high) human neuroblastoma cell lines reduce proliferation in response to HTR3A-specific agonists. In embryos (in vivo), the physiological increase of 5HT caused a prolongation of the cell cycle in "bridge" progenitors leading to a smaller chromaffin population and changing the balance of hormones and behavioral patterns in adulthood. These behavioral effects and smaller adrenals were mirrored in the progeny of pregnant female mice subjected to experimental stress, suggesting a maternal-fetal link that controls developmental adaptations. Finally, these results corresponded to a size-distribution of adrenals found in wild rodents with different coping strategies.
ER -
KAMENEVA, Polina, Victoria I. MELNIKOVA, Maria Eleni KASTRITI, Anastasia KURTOVA, Emil KRYUKOV, Aliia MURTAZINA, Louis FAURE, Irina POVERENNAYA, Artem V. ARTEMOV, Tatiana S. KALININA, Nikita V. KUDRYASHOV, Michael BADER, Jan ŠKODA, Petr CHLAPEK, Lucie CURYLOVÁ, Lukáš SOURADA, Jakub NERADIL, Marketa TESAROVA, Massimo PASQUALETTI, Patricia GASPAR, Vasily D. YAKUSHOV, Boris I. SHEFTEL, Tomas ZIKMUND, Jozef KAISER, Kaj FRIED, Natalia ALENINA, Elena E. VORONEZHSKAYA a Igor ADAMEYKO. Serotonin limits generation of chromaffin cells during adrenal organ development. \textit{Nature Communications}. Nature Publishing Group, 2022, roč.~13, č.~1, s.~1-21. ISSN~2041-1723. Dostupné z: https://dx.doi.org/10.1038/s41467-022-30438-w.
|
