1,5-dicaffeoylquinic acid, an antioxidant component of Cynara cardunculus leaves

SLANINA, Jiří, Hana PAULOVÁ, Otakar HUMPA, Hana BOCHOŘÁKOVÁ a Eva TÁBORSKÁ. 1,5-dicaffeoylquinic acid, an antioxidant component of Cynara cardunculus leaves. Scripta Medica (BRNO). Brno: Lékařská fakulta Masarykovy univerzity, 1999, roč. 72, č. 1, s. 9-17. ISSN 1211-3395.

Základní údaje

• Originální název: 1,5-dicaffeoylquinic acid, an antioxidant component of Cynara cardunculus leaves
• Autoři: SLANINA, Jiří, Hana PAULOVÁ, Otakar HUMPA, Hana BOCHOŘÁKOVÁ a Eva TÁBORSKÁ.
• Vydání: Scripta Medica (BRNO), Brno, Lékařská fakulta Masarykovy univerzity, 1999, 1211-3395.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Článek v odborném periodiku
• Obor: 10401 Organic chemistry
• Stát vydavatele: Česká republika
• Utajení: není předmětem státního či obchodního tajemství
• Organizační jednotka: Lékařská fakulta

Anotace

This study describes the isolation, identification and some antioxidant properties of 1,5-dicaffeoylquinic acid. The title compound was isolated from the methanolic extract of the leaves of Cynara cardunculus. The isolation was based on the selective extraction of 1,5-dicaffeoylquinic acid with diethylether from weakly acidic water-methanolic solution and on column chromatography. Its structure was elucidated by 1D and 2D H-NMR spectroscopy. Inhibition of hemolysis induced by hydrogen peroxide and the antiradical effect of both 1,5-dicaffeoylquinic acid and cynarin (1,3-dicaffeoylquinic acid) were studied. Cynarin is formed from 1,5-dicaffeoylquinic acid by transesterification during the solvent extraction. Antioxidant activity of dicaffeoylquinic acids in both systems was stronger than that of ascorbic acid.