Další formáty:
BibTeX
LaTeX
RIS
@article{2212070,
author = {Říha, Pavel and Brabenec, Luboš and Mareček, Radek and Rektor, Ivan and Rektorová, Irena},
article_location = {WIEN},
article_number = {5-6},
doi = {http://dx.doi.org/10.1007/s00702-021-02451-8},
keywords = {Parkinson's disease; Aging; Hippocampus-to-cortex volume ratio; Processing speed},
language = {eng},
issn = {0300-9564},
journal = {Journal of Neural Transmission},
title = {The reduction of hippocampal volume in Parkinson's disease},
url = {https://link.springer.com/article/10.1007/s00702-021-02451-8},
volume = {129},
year = {2022}
}
TY - JOUR
ID - 2212070
AU - Říha, Pavel - Brabenec, Luboš - Mareček, Radek - Rektor, Ivan - Rektorová, Irena
PY - 2022
TI - The reduction of hippocampal volume in Parkinson's disease
JF - Journal of Neural Transmission
VL - 129
IS - 5-6
SP - 575-580
EP - 575-580
PB - SPRINGER WIEN
SN - 03009564
KW - Parkinson's disease
KW - Aging
KW - Hippocampus-to-cortex volume ratio
KW - Processing speed
UR - https://link.springer.com/article/10.1007/s00702-021-02451-8
N2 - The volume of the hippocampus decreases more slowly than the volume of the cortex during normal aging. We explored changes in the hippocampus-to-cortex volume (HV:CTV) ratio with increasing age in non-demented Parkinson's disease (PD) patients as compared to healthy controls (HC). We also evaluated the association between the HV:CTV ratio and cognitive outcomes. Altogether 130 participants without dementia aged 51-88 years were consecutively enrolled, including 54 PD patients (mean age 67, standard deviation (SD) 8 years) and 76 HC (mean age 69, SD 7 years). All participants underwent structural magnetic resonance examination and psychological evaluation. Hippocampal and cortex volumes were determined from T1 and FLAIR scans using FreeSurfer software, and the HV:CTV ratio was calculated. Regression lines for age-dependence of the HV:CTV ratio for PD and HC groups were calculated. We further assessed the association between the HV:CTV ratio and cognitive tests examining hippocampus-related cognitive functions. PD patients and age-matched HC showed a significant difference in age-dependence of HV:CTV ratio (p value = 0.012), with a decreasing slope in PD and increasing slope in HC. In the PD group, a significant correlation (R = 0.561, p = 0.024) was observed between the HV:CTV ratio and the Digit Symbol-Coding test. The reduction of HV:CTV ratio is accelerated in pathological aging due to PD pathology. The HV:CTV ratio was associated with impaired processing speed, i.e., the cognitive function that is linked to subcortical alterations of both associated basal ganglia circuitry and the hippocampus.
ER -
ŘÍHA, Pavel, Luboš BRABENEC, Radek MAREČEK, Ivan REKTOR a Irena REKTOROVÁ. The reduction of hippocampal volume in Parkinson's disease. \textit{Journal of Neural Transmission}. WIEN: SPRINGER WIEN, 2022, roč.~129, 5-6, s.~575-580. ISSN~0300-9564. Dostupné z: https://dx.doi.org/10.1007/s00702-021-02451-8.
|
