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@article{2213738,
author = {Komprda, Tomas and Sladek, Zbysek and Vicenova, Monika and Simonova, Jana and Franke, Gabriela and Kacvinska, Katarina and Sabliov, Cristina and Astete, Carlos E and Leva, Lenka and Popelkova, Vendula and Batik, Andrej and Vojtova, Lucy and Lipový, Břetislav and Matejovicova, Milena},
article_location = {Basel},
article_number = {14},
doi = {http://dx.doi.org/10.3390/ijms23147663},
keywords = {cutaneous wounds; polyunsaturated fatty acids n-3; nanoparticles; poly(lactic-co-glycolic) acid; mupirocin; collagen; hydroxyproline; cyclooxygenase-2; transforming growth factor},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Effect of Polymeric Nanoparticles with Entrapped Fish Oil or Mupirocin on Skin Wound Healing Using a Porcine Model},
url = {https://www.mdpi.com/1422-0067/23/14/7663},
volume = {23},
year = {2022}
}
TY - JOUR
ID - 2213738
AU - Komprda, Tomas - Sladek, Zbysek - Vicenova, Monika - Simonova, Jana - Franke, Gabriela - Kacvinska, Katarina - Sabliov, Cristina - Astete, Carlos E - Leva, Lenka - Popelkova, Vendula - Batik, Andrej - Vojtova, Lucy - Lipový, Břetislav - Matejovicova, Milena
PY - 2022
TI - Effect of Polymeric Nanoparticles with Entrapped Fish Oil or Mupirocin on Skin Wound Healing Using a Porcine Model
JF - International Journal of Molecular Sciences
VL - 23
IS - 14
SP - 1-20
EP - 1-20
PB - Multidisciplinary Digital Publishing Institute
SN - 14220067
KW - cutaneous wounds
KW - polyunsaturated fatty acids n-3
KW - nanoparticles
KW - poly(lactic-co-glycolic) acid
KW - mupirocin
KW - collagen
KW - hydroxyproline
KW - cyclooxygenase-2
KW - transforming growth factor
UR - https://www.mdpi.com/1422-0067/23/14/7663
N2 - The utilization of poly(lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) with entrapped fish oil (FO) loaded in collagen-based scaffolds for cutaneous wound healing using a porcine model is unique for the present study. Full-depth cutaneous excisions (5 x 5 cm) on the pig dorsa were treated with pure collagen scaffold (control, C), empty PLGA NPs (NP), FO, mupirocin (MUP), PLGA NPs with entrapped FO (NP/FO) and PLGA NPs with entrapped MUP (NP/MUP). The following markers were evaluated on days 0, 3, 7, 14 and 21 post-excision: collagen, hydroxyproline (HP), angiogenesis and expressions of the COX2, EGF, COL1A1, COL1A3, TGFB1, VEGFA, CCL5 and CCR5 genes. The hypothesis that NP/FO treatment is superior to FO alone and that it is comparable to NP/MUP was tested. NP/FO treatment increased HP in comparison with both FO alone and NP/MUP (day 14) but decreased (p < 0.05) angiogenesis in comparison with FO alone (day 3). NP/FO increased (p < 0.05) the expression of the CCR5 gene (day 3) and tended (p > 0.05) to increase the expressions of the EGF (day 7, day 14), TGFB1 (day 21) and CCL5 (day 7, day 21) genes as compared with NP/MUP. NP/FO can be suggested as a suitable alternative to NP/MUP in cutaneous wound treatment.
ER -
KOMPRDA, Tomas, Zbysek SLADEK, Monika VICENOVA, Jana SIMONOVA, Gabriela FRANKE, Katarina KACVINSKA, Cristina SABLIOV, Carlos E ASTETE, Lenka LEVA, Vendula POPELKOVA, Andrej BATIK, Lucy VOJTOVA, Břetislav LIPOVÝ a Milena MATEJOVICOVA. Effect of Polymeric Nanoparticles with Entrapped Fish Oil or Mupirocin on Skin Wound Healing Using a Porcine Model. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2022, roč.~23, č.~14, s.~1-20. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms23147663.
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