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@article{2213738, author = {Komprda, Tomas and Sladek, Zbysek and Vicenova, Monika and Simonova, Jana and Franke, Gabriela and Kacvinska, Katarina and Sabliov, Cristina and Astete, Carlos E and Leva, Lenka and Popelkova, Vendula and Batik, Andrej and Vojtova, Lucy and Lipový, Břetislav and Matejovicova, Milena}, article_location = {Basel}, article_number = {14}, doi = {http://dx.doi.org/10.3390/ijms23147663}, keywords = {cutaneous wounds; polyunsaturated fatty acids n-3; nanoparticles; poly(lactic-co-glycolic) acid; mupirocin; collagen; hydroxyproline; cyclooxygenase-2; transforming growth factor}, language = {eng}, issn = {1422-0067}, journal = {International Journal of Molecular Sciences}, title = {Effect of Polymeric Nanoparticles with Entrapped Fish Oil or Mupirocin on Skin Wound Healing Using a Porcine Model}, url = {https://www.mdpi.com/1422-0067/23/14/7663}, volume = {23}, year = {2022} }
TY - JOUR ID - 2213738 AU - Komprda, Tomas - Sladek, Zbysek - Vicenova, Monika - Simonova, Jana - Franke, Gabriela - Kacvinska, Katarina - Sabliov, Cristina - Astete, Carlos E - Leva, Lenka - Popelkova, Vendula - Batik, Andrej - Vojtova, Lucy - Lipový, Břetislav - Matejovicova, Milena PY - 2022 TI - Effect of Polymeric Nanoparticles with Entrapped Fish Oil or Mupirocin on Skin Wound Healing Using a Porcine Model JF - International Journal of Molecular Sciences VL - 23 IS - 14 SP - 1-20 EP - 1-20 PB - Multidisciplinary Digital Publishing Institute SN - 14220067 KW - cutaneous wounds KW - polyunsaturated fatty acids n-3 KW - nanoparticles KW - poly(lactic-co-glycolic) acid KW - mupirocin KW - collagen KW - hydroxyproline KW - cyclooxygenase-2 KW - transforming growth factor UR - https://www.mdpi.com/1422-0067/23/14/7663 N2 - The utilization of poly(lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) with entrapped fish oil (FO) loaded in collagen-based scaffolds for cutaneous wound healing using a porcine model is unique for the present study. Full-depth cutaneous excisions (5 x 5 cm) on the pig dorsa were treated with pure collagen scaffold (control, C), empty PLGA NPs (NP), FO, mupirocin (MUP), PLGA NPs with entrapped FO (NP/FO) and PLGA NPs with entrapped MUP (NP/MUP). The following markers were evaluated on days 0, 3, 7, 14 and 21 post-excision: collagen, hydroxyproline (HP), angiogenesis and expressions of the COX2, EGF, COL1A1, COL1A3, TGFB1, VEGFA, CCL5 and CCR5 genes. The hypothesis that NP/FO treatment is superior to FO alone and that it is comparable to NP/MUP was tested. NP/FO treatment increased HP in comparison with both FO alone and NP/MUP (day 14) but decreased (p < 0.05) angiogenesis in comparison with FO alone (day 3). NP/FO increased (p < 0.05) the expression of the CCR5 gene (day 3) and tended (p > 0.05) to increase the expressions of the EGF (day 7, day 14), TGFB1 (day 21) and CCL5 (day 7, day 21) genes as compared with NP/MUP. NP/FO can be suggested as a suitable alternative to NP/MUP in cutaneous wound treatment. ER -
KOMPRDA, Tomas, Zbysek SLADEK, Monika VICENOVA, Jana SIMONOVA, Gabriela FRANKE, Katarina KACVINSKA, Cristina SABLIOV, Carlos E ASTETE, Lenka LEVA, Vendula POPELKOVA, Andrej BATIK, Lucy VOJTOVA, Břetislav LIPOVÝ a Milena MATEJOVICOVA. Effect of Polymeric Nanoparticles with Entrapped Fish Oil or Mupirocin on Skin Wound Healing Using a Porcine Model. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2022, roč.~23, č.~14, s.~1-20. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms23147663.
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