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@proceedings{2214760, author = {Klásková, Eva and Strakošová, Markéta and Juřica, Jan and Zendulka, Ondřej}, booktitle = {27th Interdisciplinary Toxicology Conference}, keywords = {cytochrome P450, harman, metabolic activity, drug-drug interactions}, language = {eng}, title = {The effect of potential carcinogen harman on selected cytochrome P450 enzymes in rats}, url = {https://www.mmsl.cz/magno/mms/2022/mn88.php}, year = {2022} }
TY - CONF ID - 2214760 AU - Klásková, Eva - Strakošová, Markéta - Juřica, Jan - Zendulka, Ondřej PY - 2022 TI - The effect of potential carcinogen harman on selected cytochrome P450 enzymes in rats KW - cytochrome P450, harman, metabolic activity, drug-drug interactions UR - https://www.mmsl.cz/magno/mms/2022/mn88.php N2 - Harman is a heterocyclic aromatic amine discovered in coffee, cigarette smoke, roasted meat, or fish. However, carcinogenic properties of harmane were proved - partly explained by its interaction via the AhR receptor and induction of CYP1A1. Cytochrome P450 (CYP) enzymes are responsible for the metabolism of 75 % of drugs used in clinical practice. Our study aimed to determine the effects of harman on the most important CYP variants in a preclinical experiment. ER -
KLÁSKOVÁ, Eva, Markéta STRAKOŠOVÁ, Jan JUŘICA a Ondřej ZENDULKA. The effect of potential carcinogen harman on selected cytochrome P450 enzymes in rats. In \textit{27th Interdisciplinary Toxicology Conference}. 2022. ISSN~2571-113X.
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