Pollen-Based Magnetic Microrobots are Mediated by Electrostatic
Forces to Attract, Manipulate, and Kill Cancer Cells

J 2022

Pollen-Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells

MAYORGA-MARTINEZ, Carmen C., Michaela FOJTŮ, Jan VYSKOCIL, Nam-Joon CHO, Martin PUMERA et. al.

Základní údaje

Originální název

Pollen-Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells

Autoři

MAYORGA-MARTINEZ, Carmen C., Michaela FOJTŮ (203 Česká republika, domácí), Jan VYSKOCIL (203 Česká republika), Nam-Joon CHO a Martin PUMERA (203 Česká republika, garant)

Vydání

Advanced Functional Materials, Wrinheim, Wiley-VCH Verlag, 2022, 1616-301X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

21002 Nano-processes ;

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 19.000

Kód RIV

RIV/00216224:14110/22:00129685

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/adfm.202207272

UT WoS

000849040300001

Klíčová slova anglicky

biological microrobots; drug deliveries; hybrid robotics; magnetic micromotors

Štítky

14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 1. 2023 13:31, Mgr. Tereza Miškechová

Anotace

V originále

Naturally occurring micro/nanoparticles provide an incredible array of potential sources when preparing hybrid micro/nanorobots and their intrinsic properties can be exploited as multitasking functionalities of modern robotics as well as ensuring their mass production availability. Herein, magnetic biological bots (BioBots) prepared from defatted sunflower pollen microparticles by ferromagnetic metal layer evaporation on one side of its surface are described. It is demonstrated that the methodology employed introduces magnetic properties to sunflower pollen microparticles-based BioBots and enable their magnetic actuation. Interestingly, as-prepared magnetic sunflower pollen-based BioBots can naturally attract cancer cells due to their opposite charges (positive and negative, respectively). Such attracted cancer cells can then be transported by microrobots. This strong attraction also allows the delivery of drugs intended to kill the cancer cells. Sunflower-based BioBots can be fabricated in large quantities, and are naturally programmable, making them promising candidates for cancer cell therapy.

Návaznosti

NU21-08-00407, projekt VaV

Název: Funkční nanoroboti pro navigovanou kombinovanou nádorovou terapii

Investor: Ministerstvo zdravotnictví ČR, Funkční nanoroboti pro navigovanou kombinovanou nádorovou terapii, Podprogram 1 - standardní

Citovat

MAYORGA-MARTINEZ, Carmen C., Michaela FOJTŮ, Jan VYSKOCIL, Nam-Joon CHO a Martin PUMERA. Pollen-Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells. Advanced Functional Materials. Wrinheim: Wiley-VCH Verlag, 2022, roč. 32, č. 46, s. 1-8. ISSN 1616-301X. Dostupné z: https://dx.doi.org/10.1002/adfm.202207272.

@article{2217057,
   author = {MayorgaandMartinez, Carmen C. and Fojtů, Michaela and Vyskocil, Jan and Cho, NamandJoon and Pumera, Martin},
   article_location = {Wrinheim},
   article_number = {46},
   doi = {http://dx.doi.org/10.1002/adfm.202207272},
   keywords = {biological microrobots; drug deliveries; hybrid robotics; magnetic micromotors},
   language = {eng},
   issn = {1616-301X},
   journal = {Advanced Functional Materials},
   title = {Pollen-Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/adfm.202207272},
   volume = {32},
   year = {2022}
}

TY  - JOUR
ID  - 2217057
AU  - Mayorga-Martinez, Carmen C. - Fojtů, Michaela - Vyskocil, Jan - Cho, Nam-Joon - Pumera, Martin
PY  - 2022
TI  - Pollen-Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells
JF  - Advanced Functional Materials
VL  - 32
IS  - 46
SP  - 1-8
EP  - 1-8
PB  - Wiley-VCH Verlag
SN  - 1616301X
KW  - biological microrobots
KW  - drug deliveries
KW  - hybrid robotics
KW  - magnetic micromotors
UR  - https://onlinelibrary.wiley.com/doi/10.1002/adfm.202207272
N2  - Naturally occurring micro/nanoparticles provide an incredible array of potential sources when preparing hybrid micro/nanorobots and their intrinsic properties can be exploited as multitasking functionalities of modern robotics as well as ensuring their mass production availability. Herein, magnetic biological bots (BioBots) prepared from defatted sunflower pollen microparticles by ferromagnetic metal layer evaporation on one side of its surface are described. It is demonstrated that the methodology employed introduces magnetic properties to sunflower pollen microparticles-based BioBots and enable their magnetic actuation. Interestingly, as-prepared magnetic sunflower pollen-based BioBots can naturally attract cancer cells due to their opposite charges (positive and negative, respectively). Such attracted cancer cells can then be transported by microrobots. This strong attraction also allows the delivery of drugs intended to kill the cancer cells. Sunflower-based BioBots can be fabricated in large quantities, and are naturally programmable, making them promising candidates for cancer cell therapy.
ER  -

MAYORGA-MARTINEZ, Carmen C., Michaela FOJTŮ, Jan VYSKOCIL, Nam-Joon CHO a Martin PUMERA. Pollen-Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells. \textit{Advanced Functional Materials}. Wrinheim: Wiley-VCH Verlag, 2022, roč.~32, č.~46, s.~1-8. ISSN~1616-301X. Dostupné z: https://dx.doi.org/10.1002/adfm.202207272.

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