DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS
NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN
CANCER CELLS

D 2022

DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS

ONUŠČÁKOVÁ, Magdaléna, Hana PÍŽOVÁ, Tereza KAUEROVÁ, Marie HAMŠÍKOVÁ, David BEDNÁŘ et. al.

Základní údaje

Originální název

DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS

Autoři

ONUŠČÁKOVÁ, Magdaléna (703 Slovensko, garant, domácí), Hana PÍŽOVÁ (203 Česká republika, domácí), Tereza KAUEROVÁ (203 Česká republika, domácí), Marie HAMŠÍKOVÁ (203 Česká republika, domácí), David BEDNÁŘ (203 Česká republika, domácí), Peter KOLLÁR (203 Česká republika, domácí) a Pavel BOBÁĽ (703 Slovensko, domácí)

Vydání

Pague, Czech republic, Czech Chemical Society Symposium Series, od s. 28-29, 2 s. 2022

Nakladatel

Czech Chemical Society

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30107 Medicinal chemistry

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

elektronická verze "online"

Odkazy

URL

Kód RIV

RIV/00216224:14160/22:00126649

Organizační jednotka

Farmaceutická fakulta

ISSN

Klíčová slova anglicky

HDAC inhibitors_N-Hydroxy-cinnamide_derivates cancer

Příznaky

Recenzováno

Změněno: 13. 9. 2022 14:00, PharmDr. Magdaléna Onuščáková

Anotace

V originále

Histone deacetylases (HDACs) are enzymes involved in regulating fundamental cellular processes, such as cell cycle progression, differentiation, and tumorigenesis. The abnormal function of HDACs can induce various severe human diseases, including cancer, pulmonary disease, and neurodegenerative disorders. HDAC inhibitors (HDACi), which form a complex with the Zn2+ ion in the catalytic pocket of enzymes, have considerable anticancer activity. The docking study was performed using AutoDock Vina 1.2.0. program. The predicted binding affinity for HDAC enzymes suggests the high potential of the compounds tested. Biological tests confirmed the results of molecular docking.

Návaznosti

MUNI/A/1598/2020, interní kód MU

Název: Analýza antiproliferačních, proapoptotických a cytodiferenciačních účinků nově syntetizovaných hydroxamových kyselin

Investor: Masarykova univerzita, Analýza antiproliferačních, proapoptotických a cytodiferenciačních účinků nově syntetizovaných hydroxamových kyselin

MUNI/IGA/1339/2021, interní kód MU

Název: Design, synthesis and evaluation of potential metalloenzymes inhibitors (Akronym: DSEPMI)

Investor: Masarykova univerzita, Design, synthesis and evaluation of potential metalloenzymes inhibitors

Citovat

ONUŠČÁKOVÁ, Magdaléna, Hana PÍŽOVÁ, Tereza KAUEROVÁ, Marie HAMŠÍKOVÁ, David BEDNÁŘ, Peter KOLLÁR a Pavel BOBÁĽ. DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS. Online. In Radmila Řápková, Martin Fusek, Pavel Drašar. Czech Chemical Society Symposium Series. Pague, Czech republic: Czech Chemical Society, 2022, s. 28-29. ISSN 2336-7202.

@inproceedings{2217368,
   author = {Onuščáková, Magdaléna and Pížová, Hana and Kauerová, Tereza and Hamšíková, Marie and Bednář, David and Kollár, Peter and Bobáľ, Pavel},
   address = {Pague, Czech republic},
   booktitle = {Czech Chemical Society Symposium Series},
   editor = {Radmila Řápková, Martin Fusek, Pavel Drašar},
   keywords = {HDAC inhibitors_N-Hydroxy-cinnamide_derivates cancer},
   howpublished = {elektronická verze "online"},
   language = {eng},
   location = {Pague, Czech republic},
   pages = {28-29},
   publisher = {Czech Chemical Society},
   title = {DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS},
   url = {http://www.ccsss.cz/index.php/ccsss/issue/view/31/45},
   year = {2022}
}

TY  - JOUR
ID  - 2217368
AU  - Onuščáková, Magdaléna - Pížová, Hana - Kauerová, Tereza - Hamšíková, Marie - Bednář, David - Kollár, Peter - Bobáľ, Pavel
PY  - 2022
TI  - DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS
PB  - Czech Chemical Society
CY  - Pague, Czech republic
KW  - HDAC inhibitors_N-Hydroxy-cinnamide_derivates cancer
UR  - http://www.ccsss.cz/index.php/ccsss/issue/view/31/45
N2  - Histone deacetylases (HDACs) are enzymes involved in regulating fundamental cellular processes, such as cell cycle progression, differentiation, and tumorigenesis. The abnormal function of HDACs can induce various severe human diseases, including cancer, pulmonary disease, and neurodegenerative disorders. HDAC inhibitors (HDACi), which form a complex with the Zn2+ ion in the catalytic pocket of enzymes, have considerable anticancer activity. The docking study was performed using AutoDock Vina 1.2.0. program. The predicted binding affinity for HDAC enzymes suggests the high potential of the compounds tested. Biological tests confirmed the results of molecular docking.
ER  -

ONUŠČÁKOVÁ, Magdaléna, Hana PÍŽOVÁ, Tereza KAUEROVÁ, Marie HAMŠÍKOVÁ, David BEDNÁŘ, Peter KOLLÁR a Pavel BOBÁĽ. DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS. Online. In Radmila Řápková, Martin Fusek, Pavel Drašar. \textit{Czech Chemical Society Symposium Series}. Pague, Czech republic: Czech Chemical Society, 2022, s.~28-29. ISSN~2336-7202.

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