2022
SCHIFF BASES AS POTENTIAL INHIBITORS OF AMINOPEPTIDASE N AS ANTICANCER AGENTS
BALLAYOVÁ, Veronika, Radka ŽÁČKOVÁ, Tereza KAUEROVÁ, Peter KOLLÁR, Oldřich FARSA et. al.Základní údaje
Originální název
SCHIFF BASES AS POTENTIAL INHIBITORS OF AMINOPEPTIDASE N AS ANTICANCER AGENTS
Název česky
SCHIFF BASES AS POTENTIAL INHIBITORS OF AMINOPEPTIDASE N AS ANTICANCER AGENTS
Autoři
BALLAYOVÁ, Veronika (703 Slovensko, garant, domácí), Radka ŽÁČKOVÁ (203 Česká republika, domácí), Tereza KAUEROVÁ (203 Česká republika, domácí), Peter KOLLÁR (203 Česká republika, domácí) a Oldřich FARSA (203 Česká republika, domácí)
Vydání
2022
Další údaje
Jazyk
angličtina
Typ výsledku
Prezentace na konferencích
Obor
30107 Medicinal chemistry
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Kód RIV
RIV/00216224:14160/22:00126659
Organizační jednotka
Farmaceutická fakulta
Klíčová slova česky
Aminopeptidase N; AP-N; HPLC assay
Klíčová slova anglicky
Aminopeptidase N; AP-N; HPLC assay
Změněno: 30. 3. 2023 13:26, Mgr. Veronika Murgašová
V originále
Many Schiff bases appear to be important intermediates in a number of enzymatic reactions. The presence of the azomethine group, as well as their interesting physical and chemical properties, cause the widespread application of their metal complexes. Synthesized groups of basic thiosemicarbazone and semicarbazone derivatives of acetophenone have these properties as well. Aminopeptidase N (AP-N), or membrane alanyl aminopeptidase (m-AAP), is a neutral zinc-binding metallopeptidase that cleaves N-terminal residues from protein and peptides. This aminopeptidase turns out to be identical to the human cluster differentiation antigen CD13 expressed on the surface of myeloid progenitors and myeloid leukemia cells.
Česky
Many Schiff bases appear to be important intermediates in a number of enzymatic reactions. The presence of the azomethine group, as well as their interesting physical and chemical properties, cause the widespread application of their metal complexes. Synthesized groups of basic thiosemicarbazone and semicarbazone derivatives of acetophenone have these properties as well. Aminopeptidase N (AP-N), or membrane alanyl aminopeptidase (m-AAP), is a neutral zinc-binding metallopeptidase that cleaves N-terminal residues from protein and peptides. This aminopeptidase turns out to be identical to the human cluster differentiation antigen CD13 expressed on the surface of myeloid progenitors and myeloid leukemia cells.
Návaznosti
| MUNI/IGA/0932/2021, interní kód MU |
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