Herpes Simplex Keratitis in Patients with SARS-CoV-2 Infection:
A Series of Five Cases

J 2021

Herpes Simplex Keratitis in Patients with SARS-CoV-2 Infection: A Series of Five Cases

MAJTANOVA, Nora, Petra KRISKOVA, Petra KERI, Zlatica FELLNER, Juraj MAJTAN et. al.

Basic information

Original name

Herpes Simplex Keratitis in Patients with SARS-CoV-2 Infection: A Series of Five Cases

Authors

MAJTANOVA, Nora, Petra KRISKOVA, Petra KERI, Zlatica FELLNER, Juraj MAJTAN and Petr KOLÁŘ

Edition

Medicina-Lithuania, Basel, MDPI, 2021, 1010-660X

Other information

Type of outcome

Článek v odborném periodiku

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.948

DOI

http://dx.doi.org/10.3390/medicina57050412

UT WoS

000654281800001

Keywords in English

herpes simplex keratitis; COVID-19; immunosuppression; antiviral therapy

Změněno: 22/9/2022 09:44, prof. MUDr. Petr Kolář, Ph.D.

Abstract

V originále

Herpes simplex virus type 1 (HSV-1) is a leading cause of infectious blindness worldwide. Most of the initial infection cases manifest as acute epithelial keratitis. Reactivation of herpesviruses is common in critically ill patients, including patients with severe Coronavirus disease (COVID-19). However, the data on COVID-19-related ocular infections is sparse, despite recent observations that more than 30% of COVID-19-infected patients had ocular manifestations. We report five cases of HSV-1 keratitis in COVID-19 patients. In total, five COVID-19 patients underwent ophthalmic examination, showing similar symptoms, including photophobia, tearing, decreased vision, eye redness, and pain. After initial assessment, tests of visual acuity and corneal sensitivity, a fluorescein staining test, and complete anterior and posterior segment examinations were performed. A diagnosis of HSV-1 keratitis was confirmed in all cases. Therapy was initiated using a local and systemic antiviral approach together with local antibiotic and mydriatic therapy. The complete reduction of keratitis symptoms and a clear cornea was achieved in all patients within 2 weeks. SARS-CoV-2 infection may be a risk factor for developing HSV-1 keratitis, or it may act as a potential activator of this ocular disease.

Citovat

MAJTANOVA, Nora, Petra KRISKOVA, Petra KERI, Zlatica FELLNER, Juraj MAJTAN and Petr KOLÁŘ. Herpes Simplex Keratitis in Patients with SARS-CoV-2 Infection: A Series of Five Cases. Medicina-Lithuania. Basel: MDPI, 2021, vol. 57, No 5, 7 pp. ISSN 1010-660X. Available from: https://dx.doi.org/10.3390/medicina57050412.

@article{2219500,
   author = {Majtanova, Nora and Kriskova, Petra and Keri, Petra and Fellner, Zlatica and Majtan, Juraj and Kolář, Petr},
   article_location = {Basel},
   article_number = {5},
   doi = {http://dx.doi.org/10.3390/medicina57050412},
   keywords = {herpes simplex keratitis; COVID-19; immunosuppression; antiviral therapy},
   issn = {1010-660X},
   journal = {Medicina-Lithuania},
   title = {Herpes Simplex Keratitis in Patients with SARS-CoV-2 Infection: A Series of Five Cases},
   volume = {57},
   year = {2021}
}

TY  - JOUR
ID  - 2219500
AU  - Majtanova, Nora - Kriskova, Petra - Keri, Petra - Fellner, Zlatica - Majtan, Juraj - Kolář, Petr
PY  - 2021
TI  - Herpes Simplex Keratitis in Patients with SARS-CoV-2 Infection: A Series of Five Cases
JF  - Medicina-Lithuania
VL  - 57
IS  - 5
PB  - MDPI
SN  - 1010660X
KW  - herpes simplex keratitis
KW  - COVID-19
KW  - immunosuppression
KW  - antiviral therapy
N2  - Herpes simplex virus type 1 (HSV-1) is a leading cause of infectious blindness worldwide. Most of the initial infection cases manifest as acute epithelial keratitis. Reactivation of herpesviruses is common in critically ill patients, including patients with severe Coronavirus disease (COVID-19). However, the data on COVID-19-related ocular infections is sparse, despite recent observations that more than 30% of COVID-19-infected patients had ocular manifestations. We report five cases of HSV-1 keratitis in COVID-19 patients. In total, five COVID-19 patients underwent ophthalmic examination, showing similar symptoms, including photophobia, tearing, decreased vision, eye redness, and pain. After initial assessment, tests of visual acuity and corneal sensitivity, a fluorescein staining test, and complete anterior and posterior segment examinations were performed. A diagnosis of HSV-1 keratitis was confirmed in all cases. Therapy was initiated using a local and systemic antiviral approach together with local antibiotic and mydriatic therapy. The complete reduction of keratitis symptoms and a clear cornea was achieved in all patients within 2 weeks. SARS-CoV-2 infection may be a risk factor for developing HSV-1 keratitis, or it may act as a potential activator of this ocular disease.
ER  -

MAJTANOVA, Nora, Petra KRISKOVA, Petra KERI, Zlatica FELLNER, Juraj MAJTAN and Petr KOLÁŘ. Herpes Simplex Keratitis in Patients with SARS-CoV-2 Infection: A Series of Five Cases. \textit{Medicina-Lithuania}. Basel: MDPI, 2021, vol.~57, No~5, 7 pp. ISSN~1010-660X. Available from: https://dx.doi.org/10.3390/medicina57050412.

Detailed Information on Publication Record