Actin and Cytokinesis in Fission Yeasts

D 1999

Actin and Cytokinesis in Fission Yeasts

GABRIEL, Miroslav, Junpei ISHIGURO, Marie KOPECKÁ a Augustin SVOBODA

Základní údaje

Originální název

Actin and Cytokinesis in Fission Yeasts

Autoři

GABRIEL, Miroslav, Junpei ISHIGURO, Marie KOPECKÁ a Augustin SVOBODA

Vydání

Čs.Biol. spol. Brno, VII. Cytoskeletální klub, od s. 13-13, 1 s. VII. Cytoskeletální klub, 1999

Nakladatel

Čs. biologická společnost - Sekce biologie buňky

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/99:00003236

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

actin; cytokinesis; fission yeasts

Štítky

Actin, cytokinesis, fission yeasts

Změněno: 28. 2. 2001 12:40, doc. MUDr. Miroslav Gabriel, CSc.

Anotace

V originále

F-actin occurs in several forms in yeasts:(i) hypothetically F-actin is a part of cytoskeletal subsystems of membrane cytoskeleton, (ii)microfilament cables are related to cell polarity, (iii) actin patches are at regions of surface growth, (iv) F-actin as a component of actin contractile ring realises cytokinesis. This report concentrates on the function of F-actin at cell division of fission yeasts. F-actin is essential, but not a single component of mechanism of cell division. Comparison of (i) actin mutant of S.pombe, incapable to aassemble actin cytoskeleton even at permissive temperature, and (ii) inhibition of actin polymerization by cytochalasin D in S.pombe and S. japonicus suggests that F-actin contractile ring is the main component ensuring the course of cytokinesis. While in actin mutant incapability of formation of actin cytoskeleton is followed by a complex of irreversible changes of cell functions and, consequently, also by incapability of cytokinesis, inhibition of F-actin polymerization enables to identify targets of consequences of incapability to polymerise new filament structures contractile ring including and to study reversibility of the processes blocked. Inhibition of actin polymerization by cytochalasins induces relatively reversible phenocopy modelling irreversible gene mutations.

Návaznosti

GA204/97/1150, projekt VaV

Název: Buněčná stěna a morfogeneze kvasinkové buňky: role cytoskeletu

Investor: Grantová agentura ČR, Buněčná stěna a morfogeneze kvasinkové buňky: role cytoskeletu

Citovat

GABRIEL, Miroslav, Junpei ISHIGURO, Marie KOPECKÁ a Augustin SVOBODA. Actin and Cytokinesis in Fission Yeasts. In VII. Cytoskeletální klub. Čs.Biol. spol. Brno: Čs. biologická společnost - Sekce biologie buňky, 1999, s. 13-13. VII. Cytoskeletální klub.

@inproceedings{222353,
   author = {Gabriel, Miroslav and Ishiguro, Junpei and Kopecká, Marie and Svoboda, Augustin},
   address = {Brno},
   booktitle = {VII. Cytoskeletální klub},
   edition = {Čs.Biol. spol.},
   keywords = {actin; cytokinesis; fission yeasts},
   language = {eng},
   location = {Brno},
   pages = {13-13},
   publisher = {Čs. biologická společnost - Sekce biologie buňky},
   title = {Actin and Cytokinesis in Fission Yeasts},
   year = {1999}
}

TY  - JOUR
ID  - 222353
AU  - Gabriel, Miroslav - Ishiguro, Junpei - Kopecká, Marie - Svoboda, Augustin
PY  - 1999
TI  - Actin and Cytokinesis in Fission Yeasts
VL  - VII. Cytoskeletální klub
PB  - Čs. biologická společnost - Sekce biologie buňky
CY  - Brno
KW  - actin
KW  - cytokinesis
KW  - fission yeasts
N2  - F-actin occurs in several forms in yeasts:(i) hypothetically F-actin is a part of cytoskeletal subsystems of membrane cytoskeleton, (ii)microfilament cables are related to cell polarity, (iii) actin patches are at regions of surface growth, (iv) F-actin as a component of actin contractile ring realises cytokinesis. This report concentrates on the function of F-actin at cell division of fission yeasts. F-actin is essential, but not a single component of mechanism of cell division. Comparison of (i) actin mutant of S.pombe, incapable to aassemble actin cytoskeleton even at permissive temperature, and (ii) inhibition of actin polymerization by cytochalasin D in S.pombe and S. japonicus suggests that F-actin contractile ring is the main component ensuring the course of cytokinesis. While in actin mutant incapability of formation of actin cytoskeleton is followed by a complex of irreversible changes of cell functions and, consequently, also by incapability of cytokinesis, inhibition of F-actin polymerization enables to identify targets of consequences of incapability to polymerise new filament structures contractile ring including and to study reversibility of the processes blocked. Inhibition of actin polymerization by cytochalasins induces relatively reversible phenocopy modelling irreversible gene mutations.
ER  -

GABRIEL, Miroslav, Junpei ISHIGURO, Marie KOPECKÁ a Augustin SVOBODA. Actin and Cytokinesis in Fission Yeasts. In \textit{VII. Cytoskeletální klub}. Čs.Biol. spol. Brno: Čs. biologická společnost - Sekce biologie buňky, 1999, s.~13-13. VII. Cytoskeletální klub.

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