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@inproceedings{222353,
author = {Gabriel, Miroslav and Ishiguro, Junpei and Kopecká, Marie and Svoboda, Augustin},
address = {Brno},
booktitle = {VII. Cytoskeletální klub},
edition = {Čs.Biol. spol.},
keywords = {actin; cytokinesis; fission yeasts},
language = {eng},
location = {Brno},
pages = {13-13},
publisher = {Čs. biologická společnost - Sekce biologie buňky},
title = {Actin and Cytokinesis in Fission Yeasts},
year = {1999}
}
TY - JOUR
ID - 222353
AU - Gabriel, Miroslav - Ishiguro, Junpei - Kopecká, Marie - Svoboda, Augustin
PY - 1999
TI - Actin and Cytokinesis in Fission Yeasts
VL - VII. Cytoskeletální klub
PB - Čs. biologická společnost - Sekce biologie buňky
CY - Brno
KW - actin
KW - cytokinesis
KW - fission yeasts
N2 - F-actin occurs in several forms in yeasts:(i) hypothetically F-actin is a part of cytoskeletal subsystems of membrane cytoskeleton, (ii)microfilament cables are related to cell polarity, (iii) actin patches are at regions of surface growth, (iv) F-actin as a component of actin contractile ring realises cytokinesis. This report concentrates on the function of F-actin at cell division of fission yeasts. F-actin is essential, but not a single component of mechanism of cell division. Comparison of (i) actin mutant of S.pombe, incapable to aassemble actin cytoskeleton even at permissive temperature, and (ii) inhibition of actin polymerization by cytochalasin D in S.pombe and S. japonicus suggests that F-actin contractile ring is the main component ensuring the course of cytokinesis. While in actin mutant incapability of formation of actin cytoskeleton is followed by a complex of irreversible changes of cell functions and, consequently, also by incapability of cytokinesis, inhibition of F-actin polymerization enables to identify targets of consequences of incapability to polymerise new filament structures contractile ring including and to study reversibility of the processes blocked. Inhibition of actin polymerization by cytochalasins induces relatively reversible phenocopy modelling irreversible gene mutations.
ER -
GABRIEL, Miroslav, Junpei ISHIGURO, Marie KOPECKÁ a Augustin SVOBODA. Actin and Cytokinesis in Fission Yeasts. In \textit{VII. Cytoskeletální klub}. Čs.Biol. spol. Brno: Čs. biologická společnost - Sekce biologie buňky, 1999, s.~13-13. VII. Cytoskeletální klub.
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