Preparation and evaluation of spray-dried microparticles
containing N-acetylcysteine for lung application

a 2022

Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application

HOŘAVOVÁ, Hana a Jan GAJDZIOK

Základní údaje

Originální název

Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application

Autoři

HOŘAVOVÁ, Hana (203 Česká republika, domácí) a Jan GAJDZIOK (203 Česká republika, domácí)

Vydání

9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts, 2022

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

odkaz na pdf verzi "book of abstracts"

Kód RIV

RIV/00216224:14160/22:00126880

Organizační jednotka

Farmaceutická fakulta

ISBN

978-961-94230-4-2

Klíčová slova anglicky

N-acetylcysteine; spray drying; lung aplication; microparticles

Štítky

ÚFT

Příznaky

Mezinárodní význam

Změněno: 18. 1. 2023 10:28, PharmDr. Hana Hořavová

Anotace

V originále

In this paper, the author's aim was to develop a dry powder formulation of mucolytic N-acetylcysteine (NAC) intended for inhalation. As a method of preparation, spray drying was chosen. It was confirmed that spray drying of NAC is problematic due to its high hygroscopicity and low glass transition temperature (Tg). Different excipients were applied in order to enhance the powder performance - sodium hydroxide (salt formation and reduction of hygroscopicity), dextran or maltodextrin (reduction of Tg), chitosan (encapsulation), and leucine (reduction of hygroscopicity, anti-adherent). Every approach led to spherical particles, but only increasing the content of leucine generated separated particles showing the best results in 20-25 % of solid content. However, further research is needed to decrease particle size.

Návaznosti

MUNI/A/1140/2021, interní kód MU

Název: Optimalizace porozity mikročástic pro plicní aplikaci (Akronym: porogeny)

Investor: Masarykova univerzita, Optimalizace porozity mikročástic pro plicní aplikaci

MUNI/A/1213/2020, interní kód MU

Název: Formulace a hodnocení depozice mikročásticových systémů k aplikaci do plic. (Akronym: plicní mikročástice)

Investor: Masarykova univerzita, Formulace a hodnocení depozice mikročásticových systémů k aplikaci do plic.

Citovat

HOŘAVOVÁ, Hana a Jan GAJDZIOK. Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application. In 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts. 2022. ISBN 978-961-94230-4-2.

@proceedings{2224538,
   author = {Hořavová, Hana and Gajdziok, Jan},
   booktitle = {9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts},
   keywords = {N-acetylcysteine; spray drying; lung aplication; microparticles},
   language = {eng},
   isbn = {978-961-94230-4-2},
   title = {Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application},
   url = {https://bbbb2022.sfd.si/wp-content/uploads/2020/08/9th-bbbb-conference-book-of-abstracts.pdf},
   year = {2022}
}

TY  - CONF
ID  - 2224538
AU  - Hořavová, Hana - Gajdziok, Jan
PY  - 2022
TI  - Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application
SN  - 9789619423042
KW  - N-acetylcysteine
KW  - spray drying
KW  - lung aplication
KW  - microparticles
UR  - https://bbbb2022.sfd.si/wp-content/uploads/2020/08/9th-bbbb-conference-book-of-abstracts.pdf
N2  - In this paper, the author's aim was to develop a dry powder formulation of mucolytic N-acetylcysteine (NAC) intended for inhalation. As a method of preparation, spray drying was chosen. It was confirmed that spray drying of NAC is problematic due to its high hygroscopicity and low glass transition temperature (Tg). Different excipients were applied in order to enhance the powder performance - sodium hydroxide (salt formation and reduction of hygroscopicity), dextran or maltodextrin (reduction of Tg), chitosan (encapsulation), and leucine (reduction of hygroscopicity, anti-adherent). Every approach led to spherical particles, but only increasing the content of leucine generated separated particles showing the best results in 20-25 % of solid content. However, further research is needed to decrease particle size.
ER  -

HOŘAVOVÁ, Hana a Jan GAJDZIOK. Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application. In \textit{9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts}. 2022. ISBN~978-961-94230-4-2.

Podrobný výpis o publikaci