bHLH heterodimer complex variations regulate cell proliferation
activity in the meristems of Arabidopsis thaliana

J 2022

bHLH heterodimer complex variations regulate cell proliferation activity in the meristems of Arabidopsis thaliana

MOR, Eliana, Markéta PERNISOVÁ, Max MINNE, Guillaume CERUTTI, Dagmar RIPPER et. al.

Basic information

Original name

bHLH heterodimer complex variations regulate cell proliferation activity in the meristems of Arabidopsis thaliana

Authors

MOR, Eliana, Markéta PERNISOVÁ (203 Czech Republic, belonging to the institution), Max MINNE, Guillaume CERUTTI, Dagmar RIPPER, Jonah NOLF, Jennifer ANDRES, Laura RAGNI, Matias D. ZURBRIGGEN, Bert DE RYBEL and Teva VERNOUX (guarantor)

Edition

ISCIENCE, UNITED STATES, CELL PRESS, 2022, 2589-0042

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.800

RIV identification code

RIV/00216224:14310/22:00126912

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.isci.2022.105364

UT WoS

000964036200006

Keywords in English

Biological sciences; Molecular plant pathology; Natural sciences; Plant biology

Abstract

V originále

Root, shoot and lateral meristems are the main regions of cell proliferation in plants. It has been proposed that meristems might have evolved dedicated transcriptional networks to balance cell proliferation. Here, we show that basic Helix Loop Helix (bHLH) transcription factor heterodimers formed by members of the TARGET OF MONOPTEROS5 (TMO5) and LONESOME HIGHWAY (LHW) subclades are general regulators of cell proliferation in all meristems. Yet, genetics and expression analyses suggest specific functions of these transcription factors in distinct meristems, possibly due to their expression domains determining heterodimer complex variations within meristems, and to a certain extent to the absence of some of them in a given meristem. Target gene specificity analysis for heterodimer complexes focusing on the LONELY GUY gene targets further suggests differences in transcriptional responses through heterodimer diversification that could allow a common bHLH heterodimer complex module to contribute to cell proliferation control in multiple meristems.

Links

CZ.02.2.69/0.0/0.0/17_050/0008496, interní kód MU
(CEP code: EF17_050/0008496)

Name: MSCAfellow@MUNI

Investor: Ministry of Education, Youth and Sports of the CR, Priority axis 2: Development of universities and human resources for research and development

EF17_050/0008496, research and development project

Name: MSCAfellow@MUNI

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

MOR, Eliana, Markéta PERNISOVÁ, Max MINNE, Guillaume CERUTTI, Dagmar RIPPER, Jonah NOLF, Jennifer ANDRES, Laura RAGNI, Matias D. ZURBRIGGEN, Bert DE RYBEL and Teva VERNOUX. bHLH heterodimer complex variations regulate cell proliferation activity in the meristems of Arabidopsis thaliana. ISCIENCE. UNITED STATES: CELL PRESS, 2022, vol. 25, No 11, p. 105364-105382. ISSN 2589-0042. Available from: https://dx.doi.org/10.1016/j.isci.2022.105364.

@article{2224940,
   author = {Mor, Eliana and Pernisová, Markéta and Minne, Max and Cerutti, Guillaume and Ripper, Dagmar and Nolf, Jonah and Andres, Jennifer and Ragni, Laura and Zurbriggen, Matias D. and De Rybel, Bert and Vernoux, Teva},
   article_location = {UNITED STATES},
   article_number = {11},
   doi = {http://dx.doi.org/10.1016/j.isci.2022.105364},
   keywords = {Biological sciences; Molecular plant pathology; Natural sciences; Plant biology},
   language = {eng},
   issn = {2589-0042},
   journal = {ISCIENCE},
   title = {bHLH heterodimer complex variations regulate cell proliferation activity in the meristems of Arabidopsis thaliana},
   url = {https://www.cell.com/iscience/fulltext/S2589-0042(22)01636-4},
   volume = {25},
   year = {2022}
}

TY  - JOUR
ID  - 2224940
AU  - Mor, Eliana - Pernisová, Markéta - Minne, Max - Cerutti, Guillaume - Ripper, Dagmar - Nolf, Jonah - Andres, Jennifer - Ragni, Laura - Zurbriggen, Matias D. - De Rybel, Bert - Vernoux, Teva
PY  - 2022
TI  - bHLH heterodimer complex variations regulate cell proliferation activity in the meristems of Arabidopsis thaliana
JF  - ISCIENCE
VL  - 25
IS  - 11
SP  - 105364
EP  - 105364
PB  - CELL PRESS
SN  - 25890042
KW  - Biological sciences
KW  - Molecular plant pathology
KW  - Natural sciences
KW  - Plant biology
UR  - https://www.cell.com/iscience/fulltext/S2589-0042(22)01636-4
N2  - Root, shoot and lateral meristems are the main regions of cell proliferation in plants. It has been proposed that meristems might have evolved dedicated transcriptional networks to balance cell proliferation. Here, we show that basic Helix Loop Helix (bHLH) transcription factor heterodimers formed by members of the TARGET OF MONOPTEROS5 (TMO5) and LONESOME HIGHWAY (LHW) subclades are general regulators of cell proliferation in all meristems. Yet, genetics and expression analyses suggest specific functions of these transcription factors in distinct meristems, possibly due to their expression domains determining heterodimer complex variations within meristems, and to a certain extent to the absence of some of them in a given meristem. Target gene specificity analysis for heterodimer complexes focusing on the LONELY GUY gene targets further suggests differences in transcriptional responses through heterodimer diversification that could allow a common bHLH heterodimer complex module to contribute to cell proliferation control in multiple meristems.
ER  -

MOR, Eliana, Markéta PERNISOVÁ, Max MINNE, Guillaume CERUTTI, Dagmar RIPPER, Jonah NOLF, Jennifer ANDRES, Laura RAGNI, Matias D. ZURBRIGGEN, Bert DE RYBEL and Teva VERNOUX. bHLH heterodimer complex variations regulate cell proliferation activity in the meristems of Arabidopsis thaliana. \textit{ISCIENCE}. UNITED STATES: CELL PRESS, 2022, vol.~25, No~11, p.~105364-105382. ISSN~2589-0042. Available from: https://dx.doi.org/10.1016/j.isci.2022.105364.

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