Cryptococcal Pneumonia: An Unusual Complication in a COVID-19
Patient

J 2022

Cryptococcal Pneumonia: An Unusual Complication in a COVID-19 Patient

ŠTINGL, Jan, Julie HYLMAROVÁ, Martina LENGEROVÁ, Jan MALÁSKA, Jan STAŠEK et. al.

Základní údaje

Originální název

Cryptococcal Pneumonia: An Unusual Complication in a COVID-19 Patient

Autoři

ŠTINGL, Jan (203 Česká republika, domácí), Julie HYLMAROVÁ (203 Česká republika, domácí), Martina LENGEROVÁ (203 Česká republika, domácí), Jan MALÁSKA (203 Česká republika, domácí) a Jan STAŠEK (203 Česká republika, domácí)

Vydání

Diagnostics, Basel, MDPI, 2022, 2075-4418

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30218 General and internal medicine

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.600

Kód RIV

RIV/00216224:14110/22:00126933

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/diagnostics12081944

UT WoS

000847072100001

Klíčová slova anglicky

Cryptococcus; COVID-19; SARS-CoV-2; fungal superinfection

Štítky

14110212, 14110230, 14110233, 14110528

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 4. 2023 13:51, Mgr. Tereza Miškechová

Anotace

V originále

Cryptococcal superinfection is a rare but potentially fatal complication, especially if its detection and subsequent treatment are delayed. Histopathological findings of pulmonary parenchyma from a deceased patient with these complications were acquired. Quite interestingly, only a minimal inflammatory reaction could be seen in an individual with no previously known immune suppression, indicating a disturbance of the immune system. This finding was well in concordance with the described changes in cellular immunity in COVID-19. We report the case of a 60 year old male with critical coronavirus disease 2019 (COVID-19) complicated by cryptococcal pneumonia and multiorgan failure. Both X-ray and CT scans revealed lung infiltrates corresponding with COVID-19 infection early after the onset of symptoms. Despite receiving standard treatment, the patient progressed into multiple organ failure, requiring mechanical ventilation, circulatory support, and haemodialysis. Cryptococcus neoformans was detected by subsequent BAL, and specific antifungal treatment was instituted. His clinical status deteriorated despite all treatment, and he died of refractory circulatory failure after 21 days from hospital admission. Histopathological findings confirmed severe diffuse alveolar damage (DAD) caused by COVID-19 and cryptococcal pneumonia. Timely diagnosis of cryptococcal superinfection may be challenging; therefore, PCR panels detecting even uncommon pathogens should be implemented while taking care of critical COVID-19 patients.

Návaznosti

CZ.02.1.01/0.0/0.0/16_013/0001826, interní kód MU
(Kód CEP: EF16_013/0001826)

Název: CZECRIN_PRO PACIENTY - zavádění inovativních moderních terapií

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CZECRIN_PRO PACIENTY - zavádění inovativních moderních terapií, PO 1 Posilování kapacit pro kvalitní výzkum

90128, velká výzkumná infrastruktura

Název: CZECRIN III

Citovat

ŠTINGL, Jan, Julie HYLMAROVÁ, Martina LENGEROVÁ, Jan MALÁSKA a Jan STAŠEK. Cryptococcal Pneumonia: An Unusual Complication in a COVID-19 Patient. Diagnostics. Basel: MDPI, 2022, roč. 12, č. 8, s. 1-7. ISSN 2075-4418. Dostupné z: https://dx.doi.org/10.3390/diagnostics12081944.

@article{2225482,
   author = {Štingl, Jan and Hylmarová, Julie and Lengerová, Martina and Maláska, Jan and Stašek, Jan},
   article_location = {Basel},
   article_number = {8},
   doi = {http://dx.doi.org/10.3390/diagnostics12081944},
   keywords = {Cryptococcus; COVID-19; SARS-CoV-2; fungal superinfection},
   language = {eng},
   issn = {2075-4418},
   journal = {Diagnostics},
   title = {Cryptococcal Pneumonia: An Unusual Complication in a COVID-19 Patient},
   url = {https://www.mdpi.com/2075-4418/12/8/1944},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 2225482
AU  - Štingl, Jan - Hylmarová, Julie - Lengerová, Martina - Maláska, Jan - Stašek, Jan
PY  - 2022
TI  - Cryptococcal Pneumonia: An Unusual Complication in a COVID-19 Patient
JF  - Diagnostics
VL  - 12
IS  - 8
SP  - 1-7
EP  - 1-7
PB  - MDPI
SN  - 20754418
KW  - Cryptococcus
KW  - COVID-19
KW  - SARS-CoV-2
KW  - fungal superinfection
UR  - https://www.mdpi.com/2075-4418/12/8/1944
N2  - Cryptococcal superinfection is a rare but potentially fatal complication, especially if its detection and subsequent treatment are delayed. Histopathological findings of pulmonary parenchyma from a deceased patient with these complications were acquired. Quite interestingly, only a minimal inflammatory reaction could be seen in an individual with no previously known immune suppression, indicating a disturbance of the immune system. This finding was well in concordance with the described changes in cellular immunity in COVID-19. We report the case of a 60 year old male with critical coronavirus disease 2019 (COVID-19) complicated by cryptococcal pneumonia and multiorgan failure. Both X-ray and CT scans revealed lung infiltrates corresponding with COVID-19 infection early after the onset of symptoms. Despite receiving standard treatment, the patient progressed into multiple organ failure, requiring mechanical ventilation, circulatory support, and haemodialysis. Cryptococcus neoformans was detected by subsequent BAL, and specific antifungal treatment was instituted. His clinical status deteriorated despite all treatment, and he died of refractory circulatory failure after 21 days from hospital admission. Histopathological findings confirmed severe diffuse alveolar damage (DAD) caused by COVID-19 and cryptococcal pneumonia. Timely diagnosis of cryptococcal superinfection may be challenging; therefore, PCR panels detecting even uncommon pathogens should be implemented while taking care of critical COVID-19 patients.
ER  -

ŠTINGL, Jan, Julie HYLMAROVÁ, Martina LENGEROVÁ, Jan MALÁSKA a Jan STAŠEK. Cryptococcal Pneumonia: An Unusual Complication in a COVID-19 Patient. \textit{Diagnostics}. Basel: MDPI, 2022, roč.~12, č.~8, s.~1-7. ISSN~2075-4418. Dostupné z: https://dx.doi.org/10.3390/diagnostics12081944.

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