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@article{2225482,
author = {Štingl, Jan and Hylmarová, Julie and Lengerová, Martina and Maláska, Jan and Stašek, Jan},
article_location = {Basel},
article_number = {8},
doi = {http://dx.doi.org/10.3390/diagnostics12081944},
keywords = {Cryptococcus; COVID-19; SARS-CoV-2; fungal superinfection},
language = {eng},
issn = {2075-4418},
journal = {Diagnostics},
title = {Cryptococcal Pneumonia: An Unusual Complication in a COVID-19 Patient},
url = {https://www.mdpi.com/2075-4418/12/8/1944},
volume = {12},
year = {2022}
}
TY - JOUR
ID - 2225482
AU - Štingl, Jan - Hylmarová, Julie - Lengerová, Martina - Maláska, Jan - Stašek, Jan
PY - 2022
TI - Cryptococcal Pneumonia: An Unusual Complication in a COVID-19 Patient
JF - Diagnostics
VL - 12
IS - 8
SP - 1-7
EP - 1-7
PB - MDPI
SN - 20754418
KW - Cryptococcus
KW - COVID-19
KW - SARS-CoV-2
KW - fungal superinfection
UR - https://www.mdpi.com/2075-4418/12/8/1944
N2 - Cryptococcal superinfection is a rare but potentially fatal complication, especially if its detection and subsequent treatment are delayed. Histopathological findings of pulmonary parenchyma from a deceased patient with these complications were acquired. Quite interestingly, only a minimal inflammatory reaction could be seen in an individual with no previously known immune suppression, indicating a disturbance of the immune system. This finding was well in concordance with the described changes in cellular immunity in COVID-19. We report the case of a 60 year old male with critical coronavirus disease 2019 (COVID-19) complicated by cryptococcal pneumonia and multiorgan failure. Both X-ray and CT scans revealed lung infiltrates corresponding with COVID-19 infection early after the onset of symptoms. Despite receiving standard treatment, the patient progressed into multiple organ failure, requiring mechanical ventilation, circulatory support, and haemodialysis. Cryptococcus neoformans was detected by subsequent BAL, and specific antifungal treatment was instituted. His clinical status deteriorated despite all treatment, and he died of refractory circulatory failure after 21 days from hospital admission. Histopathological findings confirmed severe diffuse alveolar damage (DAD) caused by COVID-19 and cryptococcal pneumonia. Timely diagnosis of cryptococcal superinfection may be challenging; therefore, PCR panels detecting even uncommon pathogens should be implemented while taking care of critical COVID-19 patients.
ER -
ŠTINGL, Jan, Julie HYLMAROVÁ, Martina LENGEROVÁ, Jan MALÁSKA and Jan STAŠEK. Cryptococcal Pneumonia: An Unusual Complication in a COVID-19 Patient. \textit{Diagnostics}. Basel: MDPI, 2022, vol.~12, No~8, p.~1-7. ISSN~2075-4418. Available from: https://dx.doi.org/10.3390/diagnostics12081944.
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