Promising effect of topical antimicrobial ‘biobetters’ against
methicillin-resistant Staphylococcus aureus strains

J 2022

Promising effect of topical antimicrobial ‘biobetters’ against methicillin-resistant Staphylococcus aureus strains

RAŠKA, Filip, Břetislav LIPOVÝ, Jakub HOLOUBEK, Š. KOBZOVÁ, Lukáš VACEK et. al.

Základní údaje

Originální název

Promising effect of topical antimicrobial ‘biobetters’ against methicillin-resistant Staphylococcus aureus strains

Autoři

RAŠKA, Filip (203 Česká republika, domácí), Břetislav LIPOVÝ (203 Česká republika, domácí), Jakub HOLOUBEK (203 Česká republika, domácí), Š. KOBZOVÁ (203 Česká republika), Lukáš VACEK (203 Česká republika, domácí), L. VOJTOVÁ a L. JANDA (203 Česká republika)

Vydání

Burns, OXON, ELSEVIER SCI LTD, 2022, 0305-4179

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30212 Surgery

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.700

Kód RIV

RIV/00216224:14110/22:00127028

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.burns.2022.08.011

UT WoS

000880116100012

Klíčová slova anglicky

topical antimicrobial 'biobetters'; methicillin-resistant Staphylococcus aureus strains

Štítky

14110113, 14110229, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 1. 2023 13:36, Mgr. Tereza Miškechová

Anotace

V originále

Successful control of burn wound infection is one of the keystones in the successful treatment of patients with burn injury. The increase in the prevalence of resistant strains of pathogens dramatically reduces the options of antibiotic treatment. Infectious complications caused by methicillin-resistant Staphylococcus aureus (MRSA) are known to be associated with significantly higher mortality than those caused by methicillin-sensitive strains (MSSA; 42 % and 18 %, respectively). This situation underlines the necessity for other strategies to control infectious complications of burn wounds. The use of enzybiotics (such as endolysins and lysostaphins), specific products of bacteriophages or competing bacteria, appears to be a promising alternative approach. Their advantages include high specificity and, in particular, they appear less susceptible to the development of resistant strains of bacteria. The principal limitations of the current options for the use of enzybiotics in the topical treatment of MRSA-induced burn wound infections are 1) low production associated with a high price, 2) short duration of the enzymatic activity, which is caused by the structural instability of enzymes resulting in protein denaturation and 3) low resistance of the enzyme to proteases – in particular, matrix metalloproteinases (MMPs), which are produced in the burn wound area in high amounts.

Citovat

RAŠKA, Filip, Břetislav LIPOVÝ, Jakub HOLOUBEK, Š. KOBZOVÁ, Lukáš VACEK, L. VOJTOVÁ a L. JANDA. Promising effect of topical antimicrobial ‘biobetters’ against methicillin-resistant Staphylococcus aureus strains. Burns. OXON: ELSEVIER SCI LTD, 2022, roč. 48, č. 7, s. 1770-1772. ISSN 0305-4179. Dostupné z: https://dx.doi.org/10.1016/j.burns.2022.08.011.

@article{2227364,
   author = {Raška, Filip and Lipový, Břetislav and Holoubek, Jakub and Kobzová, Š. and Vacek, Lukáš and Vojtová, L. and Janda, L.},
   article_location = {OXON},
   article_number = {7},
   doi = {http://dx.doi.org/10.1016/j.burns.2022.08.011},
   keywords = {topical antimicrobial 'biobetters'; methicillin-resistant Staphylococcus aureus strains},
   language = {eng},
   issn = {0305-4179},
   journal = {Burns},
   title = {Promising effect of topical antimicrobial ‘biobetters’ against methicillin-resistant Staphylococcus aureus strains},
   url = {https://www.sciencedirect.com/science/article/pii/S0305417922002212?via%3Dihub},
   volume = {48},
   year = {2022}
}

TY  - JOUR
ID  - 2227364
AU  - Raška, Filip - Lipový, Břetislav - Holoubek, Jakub - Kobzová, Š. - Vacek, Lukáš - Vojtová, L. - Janda, L.
PY  - 2022
TI  - Promising effect of topical antimicrobial ‘biobetters’ against methicillin-resistant Staphylococcus aureus strains
JF  - Burns
VL  - 48
IS  - 7
SP  - 1770-1772
EP  - 1770-1772
PB  - ELSEVIER SCI LTD
SN  - 03054179
KW  - topical antimicrobial 'biobetters'
KW  - methicillin-resistant Staphylococcus aureus strains
UR  - https://www.sciencedirect.com/science/article/pii/S0305417922002212?via%3Dihub
N2  - Successful control of burn wound infection is one of the keystones in the successful treatment of patients with burn injury. The increase in the prevalence of resistant strains of pathogens dramatically reduces the options of antibiotic treatment. Infectious complications caused by methicillin-resistant Staphylococcus aureus (MRSA) are known to be associated with significantly higher mortality than those caused by methicillin-sensitive strains (MSSA; 42 % and 18 %, respectively). This situation underlines the necessity for other strategies to control infectious complications of burn wounds. The use of enzybiotics (such as endolysins and lysostaphins), specific products of bacteriophages or competing bacteria, appears to be a promising alternative approach. Their advantages include high specificity and, in particular, they appear less susceptible to the development of resistant strains of bacteria. The principal limitations of the current options for the use of enzybiotics in the topical treatment of MRSA-induced burn wound infections are 1) low production associated with a high price, 2) short duration of the enzymatic activity, which is caused by the structural instability of enzymes resulting in protein denaturation and 3) low resistance of the enzyme to proteases – in particular, matrix metalloproteinases (MMPs), which are produced in the burn wound area in high amounts.
ER  -

RAŠKA, Filip, Břetislav LIPOVÝ, Jakub HOLOUBEK, Š. KOBZOVÁ, Lukáš VACEK, L. VOJTOVÁ a L. JANDA. Promising effect of topical antimicrobial ‘biobetters’ against methicillin-resistant Staphylococcus aureus strains. \textit{Burns}. OXON: ELSEVIER SCI LTD, 2022, roč.~48, č.~7, s.~1770-1772. ISSN~0305-4179. Dostupné z: https://dx.doi.org/10.1016/j.burns.2022.08.011.

Podrobný výpis o publikaci