Volumetric Analysis of Hepatocellular Carcinoma After
Transarterial Chemoembolization and its Impact on Overall
Survival.

J 2022

Volumetric Analysis of Hepatocellular Carcinoma After Transarterial Chemoembolization and its Impact on Overall Survival.

HÁJKOVÁ, Monika, Tomáš ANDRAŠINA, Petra OVESNÁ, Tomáš ROHAN, Marek DOSTÁL et. al.

Základní údaje

Originální název

Volumetric Analysis of Hepatocellular Carcinoma After Transarterial Chemoembolization and its Impact on Overall Survival.

Autoři

HÁJKOVÁ, Monika (203 Česká republika, garant, domácí), Tomáš ANDRAŠINA (703 Slovensko, domácí), Petra OVESNÁ (203 Česká republika, domácí), Tomáš ROHAN (203 Česká republika, domácí), Marek DOSTÁL (203 Česká republika, domácí), Vlastimil VÁLEK (203 Česká republika, domácí), Lenka OSTŘÍŽKOVÁ (203 Česká republika), Štěpán TUČEK (203 Česká republika), Jiří ŠEDO (203 Česká republika) a Igor KISS (203 Česká republika)

Vydání

In vivo, KAPANDRITI, International Institute of Anticancer Research, 2022, 0258-851X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30224 Radiology, nuclear medicine and medical imaging

Stát vydavatele

Řecko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.300

Kód RIV

RIV/00216224:14110/22:00127050

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.21873/invivo.12964

UT WoS

000863324700016

Klíčová slova anglicky

Hepatocellular carcinoma; transarterial chemoembolization; RECIST; mRECIST; volumetric analysis

Štítky

14110216, 14110511, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 1. 2023 12:45, Mgr. Tereza Miškechová

Anotace

V originále

Background/Aim: To evaluate the prognostic value of Response Evaluation Criteria In Solid Tumors (RECIST), modified RECIST and volumetric analysis in patients with hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE). Patients and Methods: This single-center prospective cohort study included a total of 61 patients with HCC treated by transarterial chemoembolization (TACE). The response of TACE was evaluated on preprocedural and postprocedural CT by two radiologists using RECIST/mRECIST and volumetric response to treatment. Each response assessment method was used to classify the response as progressive disease, stable disease, partial response and complete response. Kaplan-Meier analysis with log-rank test was performed for each method to evaluate its ability to help predict overall survival and progression free survival. Interobserver variability and reproducibility was determined by the Pearson and Spearman correlation coefficients. Results: The median overall survival was 17.1 months and the median progression-free survival was 11.1 months. Volumetric assessment was proved to be a prognostic factor for overall survival (p<0.01) and progression-free survival (p<0.001), contrasting with RECIST and mRECIST. All three methods featured very small interobserver variability (p<0.001 for Pearson and Spearman correlation coefficients). The patients classified as having stable disease had a 3.8-fold higher risk of death than the patients classified as having a complete/partial response (HR=3.82; 95% Confidence Interval (CI)=1.32-11.02; p=0.013) and a 4.5-fold higher risk of progression (HR=4.46; 95% CI=1.72-11.61; p=0.002). Conclusion: The prognostic value of volumetric analysis in patients with HCC treated by TACE appears to be superior to RECIST and mRECIST, with a real impact in everyday practice.

Návaznosti

MUNI/A/1388/2021, interní kód MU

Název: Význam radiologických intervencí a pokročilých zobrazovacích metod v diagnostice a léčbě pacientů s maligním onemocněním

Investor: Masarykova univerzita, Význam radiologických intervencí a pokročilých zobrazovacích metod v diagnostice a léčbě pacientů s maligním onemocněním

Citovat

HÁJKOVÁ, Monika, Tomáš ANDRAŠINA, Petra OVESNÁ, Tomáš ROHAN, Marek DOSTÁL, Vlastimil VÁLEK, Lenka OSTŘÍŽKOVÁ, Štěpán TUČEK, Jiří ŠEDO a Igor KISS. Volumetric Analysis of Hepatocellular Carcinoma After Transarterial Chemoembolization and its Impact on Overall Survival. In vivo. KAPANDRITI: International Institute of Anticancer Research, 2022, roč. 36, č. 5, s. 2332-2341. ISSN 0258-851X. Dostupné z: https://dx.doi.org/10.21873/invivo.12964.

@article{2228302,
   author = {Hájková, Monika and Andrašina, Tomáš and Ovesná, Petra and Rohan, Tomáš and Dostál, Marek and Válek, Vlastimil and Ostřížková, Lenka and Tuček, Štěpán and Šedo, Jiří and Kiss, Igor},
   article_location = {KAPANDRITI},
   article_number = {5},
   doi = {http://dx.doi.org/10.21873/invivo.12964},
   keywords = {Hepatocellular carcinoma; transarterial chemoembolization; RECIST; mRECIST; volumetric analysis},
   language = {eng},
   issn = {0258-851X},
   journal = {In vivo},
   title = {Volumetric Analysis of Hepatocellular Carcinoma After Transarterial Chemoembolization and its Impact on Overall Survival.},
   url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463903/},
   volume = {36},
   year = {2022}
}

TY  - JOUR
ID  - 2228302
AU  - Hájková, Monika - Andrašina, Tomáš - Ovesná, Petra - Rohan, Tomáš - Dostál, Marek - Válek, Vlastimil - Ostřížková, Lenka - Tuček, Štěpán - Šedo, Jiří - Kiss, Igor
PY  - 2022
TI  - Volumetric Analysis of Hepatocellular Carcinoma After Transarterial Chemoembolization and its Impact on Overall Survival.
JF  - In vivo
VL  - 36
IS  - 5
SP  - 2332-2341
EP  - 2332-2341
PB  - International Institute of Anticancer Research
SN  - 0258851X
KW  - Hepatocellular carcinoma
KW  - transarterial chemoembolization
KW  - RECIST
KW  - mRECIST
KW  - volumetric analysis
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463903/
N2  - Background/Aim: To evaluate the prognostic value of Response Evaluation Criteria In Solid Tumors (RECIST), modified RECIST and volumetric analysis in patients with hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE). Patients and Methods: This single-center prospective cohort study included a total of 61 patients with HCC treated by transarterial chemoembolization (TACE). The response of TACE was evaluated on preprocedural and postprocedural CT by two radiologists using RECIST/mRECIST and volumetric response to treatment. Each response assessment method was used to classify the response as progressive disease, stable disease, partial response and complete response. Kaplan-Meier analysis with log-rank test was performed for each method to evaluate its ability to help predict overall survival and progression free survival. Interobserver variability and reproducibility was determined by the Pearson and Spearman correlation coefficients. Results: The median overall survival was 17.1 months and the median progression-free survival was 11.1 months. Volumetric assessment was proved to be a prognostic factor for overall survival (p<0.01) and progression-free survival (p<0.001), contrasting with RECIST and mRECIST. All three methods featured very small interobserver variability (p<0.001 for Pearson and Spearman correlation coefficients). The patients classified as having stable disease had a 3.8-fold higher risk of death than the patients classified as having a complete/partial response (HR=3.82; 95% Confidence Interval (CI)=1.32-11.02; p=0.013) and a 4.5-fold higher risk of progression (HR=4.46; 95% CI=1.72-11.61; p=0.002). Conclusion: The prognostic value of volumetric analysis in patients with HCC treated by TACE appears to be superior to RECIST and mRECIST, with a real impact in everyday practice.
ER  -

HÁJKOVÁ, Monika, Tomáš ANDRAŠINA, Petra OVESNÁ, Tomáš ROHAN, Marek DOSTÁL, Vlastimil VÁLEK, Lenka OSTŘÍŽKOVÁ, Štěpán TUČEK, Jiří ŠEDO a Igor KISS. Volumetric Analysis of Hepatocellular Carcinoma After Transarterial Chemoembolization and its Impact on Overall Survival. \textit{In vivo}. KAPANDRITI: International Institute of Anticancer Research, 2022, roč.~36, č.~5, s.~2332-2341. ISSN~0258-851X. Dostupné z: https://dx.doi.org/10.21873/invivo.12964.

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