J 2022

Linear Low-Intensity Extracorporeal Shockwave Therapy as a Method for Penile Rehabilitation in Erectile Dysfunction Patients after Radical Prostatectomy: A Randomized, Single-Blinded, Sham-Controlled Clinical Trial

MOTIL, Igor, Daniel MACÍK, Kateřina ŠRÁMKOVÁ, Jiří JARKOVSKÝ, Taťána ŠRÁMKOVÁ et. al.

Základní údaje

Originální název

Linear Low-Intensity Extracorporeal Shockwave Therapy as a Method for Penile Rehabilitation in Erectile Dysfunction Patients after Radical Prostatectomy: A Randomized, Single-Blinded, Sham-Controlled Clinical Trial

Autoři

MOTIL, Igor (203 Česká republika, garant), Daniel MACÍK (203 Česká republika), Kateřina ŠRÁMKOVÁ (203 Česká republika), Jiří JARKOVSKÝ (203 Česká republika, domácí) a Taťána ŠRÁMKOVÁ (203 Česká republika, domácí)

Vydání

UROLOGIA INTERNATIONALIS, BASEL, KARGER, 2022, 0042-1138

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30217 Urology and nephrology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 1.600

Kód RIV

RIV/00216224:14110/22:00127095

Organizační jednotka

Lékařská fakulta

DOI

UT WoS

000891799000011

Klíčová slova anglicky

Shockwave therapy; Penile rehabilitation; Erectile dysfunction; Radical prostatectomy

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 16. 1. 2023 12:50, Mgr. Tereza Miškechová

Anotace

V originále

Introduction: The objective of this study was to investigate the effect and feasibility of linear low-intensity extracorporeal shockwave therapy (LI-LiESWT) as a penile rehabilitation method for erectile dysfunction (ED) after bilateral nerve-sparing (NS) radical prostatectomy (RP). Methods: Patients who had undergone bilateral NS RP (either radical retropubic prostatectomy or robot-assisted laparoscopic RP), 3 or more months prior to the study, and who had no ED preoperatively and were suffering from mild to severe postoperative ED were included in the study. Four treatments were given over a 4-week period, using the PiezoWave2 device with a linear shockwave applicator and the linear shockwave tissue coverage (LSTC-ED®) technique. If the improvement in erectile function was still considered insufficient (less than an IIEF-5 score of 22–25) at 2 months after the start of LI-LiESWT, penile rehabilitation was supplemented by pharmacological penile rehabilitation. The final effect of treatment was evaluated after 12 months. The main outcome measure was changes in the five-item International Index of Erectile Function (IIEF-5) score. Results: Between September 2019 and September 2020, a total of 40 patients were included in the study and randomly divided into 2 groups: treatment group and sham group. Eight patients were excluded from the study and were not evaluated due to other conditions which required additional treatment (COVID-19 disease, postoperative incontinence, urethral stricture, and ischemic stroke). Thirty-two patients were included in the final analysis: 16 in the control group and 16 in the intervention group. At 6 months from the end of treatment, patients in both the treatment and the sham group achieved physiological IIEF-5 values, and the beneficial effect persisted for 12 months after the end of treatment. Conclusions: LI-LiESWT using the LSTC-ED® technique is a suitable and safe method for penile rehabilitation in patients with ED after bilateral NS RP, not only because of the vasculogenic effect of LI-LiESWT but also because of its neuroprotective and/or regenerative effects.