Cannabis sativa L. Bioactive Compounds and Their Protective
Role in Oxidative Stress and Inflammation

J 2022

Cannabis sativa L. Bioactive Compounds and Their Protective Role in Oxidative Stress and Inflammation

KOPUSTINSKIENE, Dalia M, Ruta MASTEIKOVÁ, Robertas LAZAUSKAS a Jurga BERNATONIENE

Základní údaje

Originální název

Cannabis sativa L. Bioactive Compounds and Their Protective Role in Oxidative Stress and Inflammation

Autoři

KOPUSTINSKIENE, Dalia M, Ruta MASTEIKOVÁ (203 Česká republika, domácí), Robertas LAZAUSKAS a Jurga BERNATONIENE (garant)

Vydání

Antioxidants, Basel, MDPI, 2022, 2076-3921

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.000

Kód RIV

RIV/00216224:14160/22:00127119

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.3390/antiox11040660

UT WoS

000786968400001

Klíčová slova anglicky

Cannabis sativa; delta-9-tetrahydrocannabinol; cannabidiol; oxidative stress; inflammation

Štítky

rivok, ÚFT

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 11. 2022 10:32, JUDr. Sabina Krejčiříková

Anotace

V originále

Cannabis (Cannabis sativa L.) plants from the family Cannabidaceae have been used since ancient times, to produce fibers, oil, and for medicinal purposes. Psychoactive delta-9-tetrahydrocannabinol (THC) and nonpsychoactive cannabidiol (CBD) are the main pharmacologically active compounds of Cannabis sativa. These compounds have, for a long time, been under extensive investigation, and their potent antioxidant and inflammatory properties have been reported, although the detailed mechanisms of their actions have not been fully clarified. CB1 receptors are suggested to be responsible for the analgesic effect of THC, while CB2 receptors may account for its immunomodulatory properties. Unlike THC, CBD has a very low affinity for both CB1 and CB2 receptors, and behaves as their negative allosteric modulator. CBD activity, as a CB2 receptor inverse agonist, could be important for CBD anti-inflammatory properties. In this review, we discuss the chemical properties and bioavailability of THC and CBD, their main mechanisms of action, and their role in oxidative stress and inflammation.

Citovat

KOPUSTINSKIENE, Dalia M, Ruta MASTEIKOVÁ, Robertas LAZAUSKAS a Jurga BERNATONIENE. Cannabis sativa L. Bioactive Compounds and Their Protective Role in Oxidative Stress and Inflammation. Antioxidants. Basel: MDPI, 2022, roč. 11, č. 4, s. 1-12. ISSN 2076-3921. Dostupné z: https://dx.doi.org/10.3390/antiox11040660.

@article{2230684,
   author = {Kopustinskiene, Dalia M and Masteiková, Ruta and Lazauskas, Robertas and Bernatoniene, Jurga},
   article_location = {Basel},
   article_number = {4},
   doi = {http://dx.doi.org/10.3390/antiox11040660},
   keywords = {Cannabis sativa; delta-9-tetrahydrocannabinol; cannabidiol; oxidative stress; inflammation},
   language = {eng},
   issn = {2076-3921},
   journal = {Antioxidants},
   title = {Cannabis sativa L. Bioactive Compounds and Their Protective Role in Oxidative Stress and Inflammation},
   url = {https://www.mdpi.com/2076-3921/11/4/660/htm},
   volume = {11},
   year = {2022}
}

TY  - JOUR
ID  - 2230684
AU  - Kopustinskiene, Dalia M - Masteiková, Ruta - Lazauskas, Robertas - Bernatoniene, Jurga
PY  - 2022
TI  - Cannabis sativa L. Bioactive Compounds and Their Protective Role in Oxidative Stress and Inflammation
JF  - Antioxidants
VL  - 11
IS  - 4
SP  - 1-12
EP  - 1-12
PB  - MDPI
SN  - 20763921
KW  - Cannabis sativa
KW  - delta-9-tetrahydrocannabinol
KW  - cannabidiol
KW  - oxidative stress
KW  - inflammation
UR  - https://www.mdpi.com/2076-3921/11/4/660/htm
N2  - Cannabis (Cannabis sativa L.) plants from the family Cannabidaceae have been used since ancient times, to produce fibers, oil, and for medicinal purposes. Psychoactive delta-9-tetrahydrocannabinol (THC) and nonpsychoactive cannabidiol (CBD) are the main pharmacologically active compounds of Cannabis sativa. These compounds have, for a long time, been under extensive investigation, and their potent antioxidant and inflammatory properties have been reported, although the detailed mechanisms of their actions have not been fully clarified. CB1 receptors are suggested to be responsible for the analgesic effect of THC, while CB2 receptors may account for its immunomodulatory properties. Unlike THC, CBD has a very low affinity for both CB1 and CB2 receptors, and behaves as their negative allosteric modulator. CBD activity, as a CB2 receptor inverse agonist, could be important for CBD anti-inflammatory properties. In this review, we discuss the chemical properties and bioavailability of THC and CBD, their main mechanisms of action, and their role in oxidative stress and inflammation.
ER  -

KOPUSTINSKIENE, Dalia M, Ruta MASTEIKOVÁ, Robertas LAZAUSKAS a Jurga BERNATONIENE. Cannabis sativa L. Bioactive Compounds and Their Protective Role in Oxidative Stress and Inflammation. \textit{Antioxidants}. Basel: MDPI, 2022, roč.~11, č.~4, s.~1-12. ISSN~2076-3921. Dostupné z: https://dx.doi.org/10.3390/antiox11040660.

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