Gastro-resistant self-emulsifying pellets as a stable delivery
system for volatile monoterpene plant drug

k 2022

Gastro-resistant self-emulsifying pellets as a stable delivery system for volatile monoterpene plant drug

MACKŮ, Jan, Kateřina KUBOVÁ, Gabriela KOUTNÁ, Martina ČUBOVÁ URBANOVÁ, Eliška MAŠKOVÁ et. al.

Základní údaje

Originální název

Gastro-resistant self-emulsifying pellets as a stable delivery system for volatile monoterpene plant drug

Autoři

MACKŮ, Jan (203 Česká republika, domácí), Kateřina KUBOVÁ (203 Česká republika, garant, domácí), Gabriela KOUTNÁ (203 Česká republika, domácí), Martina ČUBOVÁ URBANOVÁ (203 Česká republika), Eliška MAŠKOVÁ (203 Česká republika), Josef MAŠEK (203 Česká republika), Miroslava PAVELKOVÁ (203 Česká republika, domácí), Jan MUSELÍK (203 Česká republika, domácí), Jakub VYSLOUŽIL (203 Česká republika, domácí), Aleš FRANC (203 Česká republika, domácí), David VETCHÝ (203 Česká republika, domácí) a Jiří BRUS (203 Česká republika)

Vydání

NanoMed 2022, 2022

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14160/22:00127132

Organizační jednotka

Farmaceutická fakulta

Klíčová slova česky

thymol; pevné samoemulgující systémy; ssNMR; přívod léřiva

Klíčová slova anglicky

thymol; solid self-emulsifying systems; ssNMR; drug delivery

Štítky

rivok, ÚFT

Příznaky

Mezinárodní význam

Změněno: 11. 11. 2022 15:36, doc. PharmDr. Kateřina Kubová, Ph.D.

Anotace

V originále

To avoid standard therapies for gastrointestinal inflammatory diseases, an interest in finding new alternatives is rising. Plant monoterpene substances, such as thymol, carvacrol, eugenol, etc., exhibit many valuable biological activities in treating intestinal inflammation. The basic problem is that monoterpenes are volatile hydrophobic substances with poor oral bioavailability. Thymol is only partially absorbed mainly from the stomach, resulting in a 16% bioavailability. It is cumulated in a higher amount of intestinal mucosa. Thymol could be incorporated into solid self-emulsifying (SE) pellets with gastro-resistant properties to overcome drawbacks and support intestinal wall cumulation. During pellets formulation by extrusion/spheronisation, liquid and solid phases are in temporary or permanent contact. It opens the scope for interactions, instabilities, and components transfer within the dosage form. Therefore, a deep investigation of such a system by solid-state nuclear magnetic resonance spectroscopy (ss-NMR) is also necessary. ss-NMR spectroscopy confirms that thymol and SES molecules forms homogenous liquid films/phases on the surface. A more detailed investigation revealed that the thymol molecules in the uncoated sample with long-time prepareation exhibited lower molecular dynamics compared to shorter methods, indicating a higher impact of interactions between the Neusilin surface and drug.

Návaznosti

GA22-03187S, projekt VaV

Název: Racionální design částicových polysacharidových systémů pro přívod léčiv s širokým spekterem biologické aktivity k terapii sliznic (Akronym: 22-03187S)

Investor: Grantová agentura ČR, Racionální design částicových polysacharidových systémů pro přívod léčiv s širokým spektrem biologické aktivity k terapii sliznic

Citovat

MACKŮ, Jan, Kateřina KUBOVÁ, Gabriela KOUTNÁ, Martina ČUBOVÁ URBANOVÁ, Eliška MAŠKOVÁ, Josef MAŠEK, Miroslava PAVELKOVÁ, Jan MUSELÍK, Jakub VYSLOUŽIL, Aleš FRANC, David VETCHÝ a Jiří BRUS. Gastro-resistant self-emulsifying pellets as a stable delivery system for volatile monoterpene plant drug. In NanoMed 2022. 2022.

@proceedings{2230924,
   author = {Macků, Jan and Kubová, Kateřina and Koutná, Gabriela and Čubová Urbanová, Martina and Mašková, Eliška and Mašek, Josef and Pavelková, Miroslava and Muselík, Jan and Vysloužil, Jakub and Franc, Aleš and Vetchý, David and Brus, Jiří},
   booktitle = {NanoMed 2022},
   keywords = {thymol; solid self-emulsifying systems; ssNMR; drug delivery},
   language = {eng},
   title = {Gastro-resistant self-emulsifying pellets as a stable delivery system for volatile monoterpene plant drug},
   url = {https://www.setcor.org/conferences/nanomed-2022},
   year = {2022}
}

TY  - CONF
ID  - 2230924
AU  - Macků, Jan - Kubová, Kateřina - Koutná, Gabriela - Čubová Urbanová, Martina - Mašková, Eliška - Mašek, Josef - Pavelková, Miroslava - Muselík, Jan - Vysloužil, Jakub - Franc, Aleš - Vetchý, David - Brus, Jiří
PY  - 2022
TI  - Gastro-resistant self-emulsifying pellets as a stable delivery system for volatile monoterpene plant drug
KW  - thymol
KW  - solid self-emulsifying systems
KW  - ssNMR
KW  - drug delivery
UR  - https://www.setcor.org/conferences/nanomed-2022
N2  - To avoid standard therapies for gastrointestinal inflammatory diseases, an interest in finding new alternatives is rising. Plant monoterpene substances, such as thymol, carvacrol, eugenol, etc., exhibit many valuable biological activities in treating intestinal inflammation. The basic problem is that monoterpenes are volatile hydrophobic substances with poor oral bioavailability. Thymol is only partially absorbed mainly from the stomach, resulting in a 16% bioavailability. It is cumulated in a higher amount of intestinal mucosa. Thymol could be incorporated into solid self-emulsifying (SE) pellets with gastro-resistant properties to overcome drawbacks and support intestinal wall cumulation. During pellets formulation by extrusion/spheronisation, liquid and solid phases are in temporary or permanent contact. It opens the scope for interactions, instabilities, and components transfer within the dosage form. Therefore, a deep investigation of such a system by solid-state nuclear magnetic resonance spectroscopy (ss-NMR) is also necessary. ss-NMR spectroscopy confirms that thymol and SES molecules forms homogenous liquid films/phases on the surface. A more detailed investigation revealed that the thymol molecules in the uncoated sample with long-time prepareation exhibited lower molecular dynamics compared to shorter methods, indicating a higher impact of interactions between the Neusilin surface and drug.
ER  -

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