Inflammation and fibrosis characterize different stages of
myocardial remodeling in patients after stereotactic body
radiotherapy of ventricular myocardium for recurrent
ventricular tachycardia

J 2023

Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia

KUČERA, Tomáš, Kristína JEDLIČKOVÁ, Marek ŠRAMKO, Petr PEICHL, Jakub CVEK et. al.

Základní údaje

Originální název

Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia

Autoři

KUČERA, Tomáš (203 Česká republika, garant), Kristína JEDLIČKOVÁ (203 Česká republika), Marek ŠRAMKO (203 Česká republika), Petr PEICHL (203 Česká republika), Jakub CVEK (203 Česká republika), Lukáš KNYBEL (203 Česká republika), Pavel HURNÍK (203 Česká republika), Radek NEUWIRTH (203 Česká republika, domácí), Otakar JIRAVSKÝ (203 Česká republika, domácí), Luděk VOSKA (203 Česká republika) a Josef KAUTZNER (203 Česká republika)

Vydání

CARDIOVASCULAR PATHOLOGY, NEW YORK, ELSEVIER SCIENCE INC, 2023, 1054-8807

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.700 v roce 2022

Kód RIV

RIV/00216224:14110/23:00130065

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.carpath.2022.107488

UT WoS

000892258800002

Klíčová slova anglicky

radioablation; arrhythmia; apoptosis; inflammation; macrophage; immunohistochemistry

Štítky

14110211, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 29. 1. 2024 14:44, Mgr. Tereza Miškechová

Anotace

V originále

We performed a histological and immunohistochemical analysis of myocardia from 3 patients who un-derwent radiosurgery and died for various reasons 3 months to 9 months after radiotherapy. In Case 1 (death 3 months after radiotherapy) we observed a sharp transition between relatively intact and irradiated regions. In the myolytic foci, only scattered cardiomyocytes were left and the area was in-filtrated by immune cells. Using immunohistochemistry we detected numerous inflammatory cells in-cluding CD68 + /CD11c + macrophages, CD4 + and CD8 + T-lymphocytes and some scattered CD20 + B-lymphocytes. Mast cells were diminished in contrast to viable myocardium. In Case 2 and Case 3 (death 6 and 9 months after radiotherapy, respectively) we found mostly fibrosis, infiltration by adipose tissue and foci of calcification. Inflammatory infiltrates were less pronounced. Our observations are in accor-dance with animal experimental studies and confirm a progress from myolysis to fibrosis. In addition, we demonstrate a role of pro-inflammatory macrophages in the earlier stages of myocardial remodeling after stereotactic radioablation for ventricular tachycardia.

Citovat

KUČERA, Tomáš, Kristína JEDLIČKOVÁ, Marek ŠRAMKO, Petr PEICHL, Jakub CVEK, Lukáš KNYBEL, Pavel HURNÍK, Radek NEUWIRTH, Otakar JIRAVSKÝ, Luděk VOSKA a Josef KAUTZNER. Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia. CARDIOVASCULAR PATHOLOGY. NEW YORK: ELSEVIER SCIENCE INC, 2023, roč. 62, January-February 2023, s. 1-8. ISSN 1054-8807. Dostupné z: https://dx.doi.org/10.1016/j.carpath.2022.107488.

@article{2231817,
   author = {Kučera, Tomáš and Jedličková, Kristína and Šramko, Marek and Peichl, Petr and Cvek, Jakub and Knybel, Lukáš and Hurník, Pavel and Neuwirth, Radek and Jiravský, Otakar and Voska, Luděk and Kautzner, Josef},
   article_location = {NEW YORK},
   article_number = {January-February 2023},
   doi = {http://dx.doi.org/10.1016/j.carpath.2022.107488},
   keywords = {radioablation; arrhythmia; apoptosis; inflammation; macrophage; immunohistochemistry},
   language = {eng},
   issn = {1054-8807},
   journal = {CARDIOVASCULAR PATHOLOGY},
   title = {Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia},
   url = {https://www.sciencedirect.com/science/article/pii/S1054880722000825?via%3Dihub},
   volume = {62},
   year = {2023}
}

TY  - JOUR
ID  - 2231817
AU  - Kučera, Tomáš - Jedličková, Kristína - Šramko, Marek - Peichl, Petr - Cvek, Jakub - Knybel, Lukáš - Hurník, Pavel - Neuwirth, Radek - Jiravský, Otakar - Voska, Luděk - Kautzner, Josef
PY  - 2023
TI  - Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia
JF  - CARDIOVASCULAR PATHOLOGY
VL  - 62
IS  - January-February 2023
SP  - 1-8
EP  - 1-8
PB  - ELSEVIER SCIENCE INC
SN  - 10548807
KW  - radioablation
KW  - arrhythmia
KW  - apoptosis
KW  - inflammation
KW  - macrophage
KW  - immunohistochemistry
UR  - https://www.sciencedirect.com/science/article/pii/S1054880722000825?via%3Dihub
N2  - We performed a histological and immunohistochemical analysis of myocardia from 3 patients who un-derwent radiosurgery and died for various reasons 3 months to 9 months after radiotherapy. In Case 1 (death 3 months after radiotherapy) we observed a sharp transition between relatively intact and irradiated regions. In the myolytic foci, only scattered cardiomyocytes were left and the area was in-filtrated by immune cells. Using immunohistochemistry we detected numerous inflammatory cells in-cluding CD68 + /CD11c + macrophages, CD4 + and CD8 + T-lymphocytes and some scattered CD20 + B-lymphocytes. Mast cells were diminished in contrast to viable myocardium. In Case 2 and Case 3 (death 6 and 9 months after radiotherapy, respectively) we found mostly fibrosis, infiltration by adipose tissue and foci of calcification. Inflammatory infiltrates were less pronounced. Our observations are in accor-dance with animal experimental studies and confirm a progress from myolysis to fibrosis. In addition, we demonstrate a role of pro-inflammatory macrophages in the earlier stages of myocardial remodeling after stereotactic radioablation for ventricular tachycardia.
ER  -

KUČERA, Tomáš, Kristína JEDLIČKOVÁ, Marek ŠRAMKO, Petr PEICHL, Jakub CVEK, Lukáš KNYBEL, Pavel HURNÍK, Radek NEUWIRTH, Otakar JIRAVSKÝ, Luděk VOSKA a Josef KAUTZNER. Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia. \textit{CARDIOVASCULAR PATHOLOGY}. NEW YORK: ELSEVIER SCIENCE INC, 2023, roč.~62, January-February 2023, s.~1-8. ISSN~1054-8807. Dostupné z: https://dx.doi.org/10.1016/j.carpath.2022.107488.

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