KUČERA, Tomáš, Kristína JEDLIČKOVÁ, Marek ŠRAMKO, Petr PEICHL, Jakub CVEK, Lukáš KNYBEL, Pavel HURNÍK, Radek NEUWIRTH, Otakar JIRAVSKÝ, Luděk VOSKA a Josef KAUTZNER. Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia. CARDIOVASCULAR PATHOLOGY. NEW YORK: ELSEVIER SCIENCE INC, 2023, roč. 62, January-February 2023, s. 1-8. ISSN 1054-8807. Dostupné z: https://dx.doi.org/10.1016/j.carpath.2022.107488. |
Další formáty:
BibTeX
LaTeX
RIS
@article{2231817, author = {Kučera, Tomáš and Jedličková, Kristína and Šramko, Marek and Peichl, Petr and Cvek, Jakub and Knybel, Lukáš and Hurník, Pavel and Neuwirth, Radek and Jiravský, Otakar and Voska, Luděk and Kautzner, Josef}, article_location = {NEW YORK}, article_number = {January-February 2023}, doi = {http://dx.doi.org/10.1016/j.carpath.2022.107488}, keywords = {radioablation; arrhythmia; apoptosis; inflammation; macrophage; immunohistochemistry}, language = {eng}, issn = {1054-8807}, journal = {CARDIOVASCULAR PATHOLOGY}, title = {Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia}, url = {https://www.sciencedirect.com/science/article/pii/S1054880722000825?via%3Dihub}, volume = {62}, year = {2023} }
TY - JOUR ID - 2231817 AU - Kučera, Tomáš - Jedličková, Kristína - Šramko, Marek - Peichl, Petr - Cvek, Jakub - Knybel, Lukáš - Hurník, Pavel - Neuwirth, Radek - Jiravský, Otakar - Voska, Luděk - Kautzner, Josef PY - 2023 TI - Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia JF - CARDIOVASCULAR PATHOLOGY VL - 62 IS - January-February 2023 SP - 1-8 EP - 1-8 PB - ELSEVIER SCIENCE INC SN - 10548807 KW - radioablation KW - arrhythmia KW - apoptosis KW - inflammation KW - macrophage KW - immunohistochemistry UR - https://www.sciencedirect.com/science/article/pii/S1054880722000825?via%3Dihub N2 - We performed a histological and immunohistochemical analysis of myocardia from 3 patients who un-derwent radiosurgery and died for various reasons 3 months to 9 months after radiotherapy. In Case 1 (death 3 months after radiotherapy) we observed a sharp transition between relatively intact and irradiated regions. In the myolytic foci, only scattered cardiomyocytes were left and the area was in-filtrated by immune cells. Using immunohistochemistry we detected numerous inflammatory cells in-cluding CD68 + /CD11c + macrophages, CD4 + and CD8 + T-lymphocytes and some scattered CD20 + B-lymphocytes. Mast cells were diminished in contrast to viable myocardium. In Case 2 and Case 3 (death 6 and 9 months after radiotherapy, respectively) we found mostly fibrosis, infiltration by adipose tissue and foci of calcification. Inflammatory infiltrates were less pronounced. Our observations are in accor-dance with animal experimental studies and confirm a progress from myolysis to fibrosis. In addition, we demonstrate a role of pro-inflammatory macrophages in the earlier stages of myocardial remodeling after stereotactic radioablation for ventricular tachycardia. ER -
KUČERA, Tomáš, Kristína JEDLIČKOVÁ, Marek ŠRAMKO, Petr PEICHL, Jakub CVEK, Lukáš KNYBEL, Pavel HURNÍK, Radek NEUWIRTH, Otakar JIRAVSKÝ, Luděk VOSKA a Josef KAUTZNER. Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia. \textit{CARDIOVASCULAR PATHOLOGY}. NEW YORK: ELSEVIER SCIENCE INC, 2023, roč.~62, January-February 2023, s.~1-8. ISSN~1054-8807. Dostupné z: https://dx.doi.org/10.1016/j.carpath.2022.107488.
|