Self-Propelled Magnetic Dendrite-Shaped Microrobots for
Photodynamic Prostate Cancer Therapy

J 2022

Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy

PENG, Xia, Mario URSO, Jan BALVAN, Michal MASAŘÍK, Martin PUMERA et. al.

Základní údaje

Originální název

Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy

Autoři

PENG, Xia, Mario URSO, Jan BALVAN (203 Česká republika, domácí), Michal MASAŘÍK (203 Česká republika, domácí) a Martin PUMERA (203 Česká republika, garant)

Vydání

Angewandte Chemie International Edition, WEINHEIM (GERMANY), Verlag Chemie, 2022, 1433-7851

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

20601 Medical engineering

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 16.600

Kód RIV

RIV/00216224:14110/22:00127215

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/anie.202213505

UT WoS

000871719800001

Klíčová slova anglicky

Cargo Transportation; Micromachines; Micromotors; Photocatalysis; Tumor Cells

Štítky

14110515, 14110518, CF PROT, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 1. 2023 13:52, Mgr. Tereza Miškechová

Anotace

V originále

Photocatalytic micromotors that exhibit wireless and controllable motion by light have been extensively explored for cancer treatment by photodynamic therapy (PDT). However, overexpressed glutathione (GSH) in the tumor microenvironment can down-regulate the reactive oxygen species (ROS) level for cancer therapy. Herein, we present dendrite-shaped light-powered hematite microrobots as an effective GSH depletion agent for PDT of prostate cancer cells. These hematite microrobots can display negative phototactic motion under light irradiation and flexible actuation in a defined path controlled by an external magnetic field. Non-contact transportation of micro-sized cells can be achieved by manipulating the microrobot's motion. In addition, the biocompatible microrobots induce GSH depletion and greatly enhance PDT performance. The proposed dendrite-shaped hematite microrobots contribute to developing dual light/magnetic field-powered micromachines for the biomedical field.

Návaznosti

LM2018127, projekt VaV

Název: Česká infrastruktura pro integrativní strukturní biologii (Akronym: CIISB)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Czech Infrastructure for Integrative Structural Biology

NU21-08-00407, projekt VaV

Název: Funkční nanoroboti pro navigovanou kombinovanou nádorovou terapii

Investor: Ministerstvo zdravotnictví ČR, Funkční nanoroboti pro navigovanou kombinovanou nádorovou terapii, Podprogram 1 - standardní

90110, velká výzkumná infrastruktura

Název: CzechNanoLab

Citovat

PENG, Xia, Mario URSO, Jan BALVAN, Michal MASAŘÍK a Martin PUMERA. Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy. Angewandte Chemie International Edition. WEINHEIM (GERMANY): Verlag Chemie, 2022, roč. 61, č. 48, s. 1-8. ISSN 1433-7851. Dostupné z: https://dx.doi.org/10.1002/anie.202213505.

@article{2233422,
   author = {Peng, Xia and Urso, Mario and Balvan, Jan and Masařík, Michal and Pumera, Martin},
   article_location = {WEINHEIM (GERMANY)},
   article_number = {48},
   doi = {http://dx.doi.org/10.1002/anie.202213505},
   keywords = {Cargo Transportation; Micromachines; Micromotors; Photocatalysis; Tumor Cells},
   language = {eng},
   issn = {1433-7851},
   journal = {Angewandte Chemie International Edition},
   title = {Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/anie.202213505},
   volume = {61},
   year = {2022}
}

TY  - JOUR
ID  - 2233422
AU  - Peng, Xia - Urso, Mario - Balvan, Jan - Masařík, Michal - Pumera, Martin
PY  - 2022
TI  - Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy
JF  - Angewandte Chemie International Edition
VL  - 61
IS  - 48
SP  - 1-8
EP  - 1-8
PB  - Verlag Chemie
SN  - 14337851
KW  - Cargo Transportation
KW  - Micromachines
KW  - Micromotors
KW  - Photocatalysis
KW  - Tumor Cells
UR  - https://onlinelibrary.wiley.com/doi/10.1002/anie.202213505
N2  - Photocatalytic micromotors that exhibit wireless and controllable motion by light have been extensively explored for cancer treatment by photodynamic therapy (PDT). However, overexpressed glutathione (GSH) in the tumor microenvironment can down-regulate the reactive oxygen species (ROS) level for cancer therapy. Herein, we present dendrite-shaped light-powered hematite microrobots as an effective GSH depletion agent for PDT of prostate cancer cells. These hematite microrobots can display negative phototactic motion under light irradiation and flexible actuation in a defined path controlled by an external magnetic field. Non-contact transportation of micro-sized cells can be achieved by manipulating the microrobot's motion. In addition, the biocompatible microrobots induce GSH depletion and greatly enhance PDT performance. The proposed dendrite-shaped hematite microrobots contribute to developing dual light/magnetic field-powered micromachines for the biomedical field.
ER  -

PENG, Xia, Mario URSO, Jan BALVAN, Michal MASAŘÍK a Martin PUMERA. Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy. \textit{Angewandte Chemie International Edition}. WEINHEIM (GERMANY): Verlag Chemie, 2022, roč.~61, č.~48, s.~1-8. ISSN~1433-7851. Dostupné z: https://dx.doi.org/10.1002/anie.202213505.

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