Ventilatory efficiency is superior to peak oxygen uptake for
prediction of lung resection cardiovascular complications

J 2022

Ventilatory efficiency is superior to peak oxygen uptake for prediction of lung resection cardiovascular complications

MAZÚR, Andrej, Kristián BRAT, Pavel HOMOLKA, Zdeněk MERTA, Michal SVOBODA et. al.

Základní údaje

Originální název

Ventilatory efficiency is superior to peak oxygen uptake for prediction of lung resection cardiovascular complications

Autoři

MAZÚR, Andrej (703 Slovensko, domácí), Kristián BRAT (703 Slovensko, domácí), Pavel HOMOLKA (203 Česká republika, domácí), Zdeněk MERTA (203 Česká republika, domácí), Michal SVOBODA (203 Česká republika, domácí), Monika BRATOVÁ (203 Česká republika, domácí), Vladimír ŠRÁMEK (203 Česká republika, domácí), Lyle OLSON a Ivan ČUNDRLE (203 Česká republika, garant, domácí)

Vydání

PLoS ONE, SAN FRANCISCO, PUBLIC LIBRARY SCIENCE, 2022, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30203 Respiratory systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.700

Kód RIV

RIV/00216224:14110/22:00127257

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1371/journal.pone.0272984

UT WoS

000944132200052

Klíčová slova anglicky

ventilatory efficiency; cardiovascular complications; peak oxygen consumption

Štítky

14110118, 14110122, 14110215, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 3. 2023 09:45, Mgr. Tereza Miškechová

Anotace

V originále

Introduction Ventilatory efficiency (VE/VCO2 slope) has been shown superior to peak oxygen consumption (VO2) for prediction of post-operative pulmonary complications in patients undergoing thoracotomy. VE/VCO2 slope is determined by ventilatory drive and ventilation/perfusion mismatch whereas VO2 is related to cardiac output and arteriovenous oxygen difference. We hypothesized pre-operative VO2 predicts post-operative cardiovascular complications in patients undergoing lung resection. Methods Lung resection candidates from a published study were evaluated by post-hoc analysis. All of the patients underwent preoperative cardiopulmonary exercise testing. Post-operative cardiovascular complications were assessed during the first 30 post-operative days or hospital stay. One-way analysis of variance or the Kruskal–Wallis test, and multivariate logistic regression were used for statistical analysis and data summarized as median (IQR). Results Of 353 subjects, 30 (9%) developed pulmonary complications only (excluded from further analysis), while 78 subjects (22%) developed cardiovascular complications and were divided into two groups for analysis: cardiovascular only (n = 49) and cardiovascular with pulmonary complications (n = 29). Compared to patients without complications (n = 245), peak VO2 was significantly lower in the cardiovascular with pulmonary complications group [19.9 ml/kg/min (16.5–25) vs. 16.3 ml/kg/min (15–20.3); P<0.01] but not in the cardiovascular only complications group [19.9 ml/kg/min (16.5–25) vs 19.0 ml/kg/min (16–23.1); P = 0.18]. In contrast, VE/VCO2 slope was significantly higher in both cardiovascular only [29 (25–33) vs. 31 (27–37); P = 0.05] and cardiovascular with pulmonary complication groups [29 (25–33) vs. 37 (34–42); P<0.01)]. Logistic regression analysis showed VE/VCO2 slope [OR = 1.06; 95%CI (1.01–1.11); P = 0.01; AUC = 0.74], but not peak VO2 to be independently associated with post-operative cardiovascular complications. Conclusion VE/VCO2 slope is superior to peak VO2 for prediction of post-operative cardiovascular complications in lung resection candidates.

Citovat

MAZÚR, Andrej, Kristián BRAT, Pavel HOMOLKA, Zdeněk MERTA, Michal SVOBODA, Monika BRATOVÁ, Vladimír ŠRÁMEK, Lyle OLSON a Ivan ČUNDRLE. Ventilatory efficiency is superior to peak oxygen uptake for prediction of lung resection cardiovascular complications. PLoS ONE. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2022, roč. 17, č. 8, s. 1-12. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0272984.

@article{2234122,
   author = {Mazúr, Andrej and Brat, Kristián and Homolka, Pavel and Merta, Zdeněk and Svoboda, Michal and Bratová, Monika and Šrámek, Vladimír and Olson, Lyle and Čundrle, Ivan},
   article_location = {SAN FRANCISCO},
   article_number = {8},
   doi = {http://dx.doi.org/10.1371/journal.pone.0272984},
   keywords = {ventilatory efficiency; cardiovascular complications; peak oxygen consumption},
   language = {eng},
   issn = {1932-6203},
   journal = {PLoS ONE},
   title = {Ventilatory efficiency is superior to peak oxygen uptake for prediction of lung resection cardiovascular complications},
   url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0272984#abstract0},
   volume = {17},
   year = {2022}
}

TY  - JOUR
ID  - 2234122
AU  - Mazúr, Andrej - Brat, Kristián - Homolka, Pavel - Merta, Zdeněk - Svoboda, Michal - Bratová, Monika - Šrámek, Vladimír - Olson, Lyle - Čundrle, Ivan
PY  - 2022
TI  - Ventilatory efficiency is superior to peak oxygen uptake for prediction of lung resection cardiovascular complications
JF  - PLoS ONE
VL  - 17
IS  - 8
SP  - 1-12
EP  - 1-12
PB  - PUBLIC LIBRARY SCIENCE
SN  - 19326203
KW  - ventilatory efficiency
KW  - cardiovascular complications
KW  - peak oxygen consumption
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0272984#abstract0
N2  - Introduction Ventilatory efficiency (VE/VCO2 slope) has been shown superior to peak oxygen consumption (VO2) for prediction of post-operative pulmonary complications in patients undergoing thoracotomy. VE/VCO2 slope is determined by ventilatory drive and ventilation/perfusion mismatch whereas VO2 is related to cardiac output and arteriovenous oxygen difference. We hypothesized pre-operative VO2 predicts post-operative cardiovascular complications in patients undergoing lung resection. Methods Lung resection candidates from a published study were evaluated by post-hoc analysis. All of the patients underwent preoperative cardiopulmonary exercise testing. Post-operative cardiovascular complications were assessed during the first 30 post-operative days or hospital stay. One-way analysis of variance or the Kruskal–Wallis test, and multivariate logistic regression were used for statistical analysis and data summarized as median (IQR). Results Of 353 subjects, 30 (9%) developed pulmonary complications only (excluded from further analysis), while 78 subjects (22%) developed cardiovascular complications and were divided into two groups for analysis: cardiovascular only (n = 49) and cardiovascular with pulmonary complications (n = 29). Compared to patients without complications (n = 245), peak VO2 was significantly lower in the cardiovascular with pulmonary complications group [19.9 ml/kg/min (16.5–25) vs. 16.3 ml/kg/min (15–20.3); P<0.01] but not in the cardiovascular only complications group [19.9 ml/kg/min (16.5–25) vs 19.0 ml/kg/min (16–23.1); P = 0.18]. In contrast, VE/VCO2 slope was significantly higher in both cardiovascular only [29 (25–33) vs. 31 (27–37); P = 0.05] and cardiovascular with pulmonary complication groups [29 (25–33) vs. 37 (34–42); P<0.01)]. Logistic regression analysis showed VE/VCO2 slope [OR = 1.06; 95%CI (1.01–1.11); P = 0.01; AUC = 0.74], but not peak VO2 to be independently associated with post-operative cardiovascular complications. Conclusion VE/VCO2 slope is superior to peak VO2 for prediction of post-operative cardiovascular complications in lung resection candidates.
ER  -

MAZÚR, Andrej, Kristián BRAT, Pavel HOMOLKA, Zdeněk MERTA, Michal SVOBODA, Monika BRATOVÁ, Vladimír ŠRÁMEK, Lyle OLSON a Ivan ČUNDRLE. Ventilatory efficiency is superior to peak oxygen uptake for prediction of lung resection cardiovascular complications. \textit{PLoS ONE}. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2022, roč.~17, č.~8, s.~1-12. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0272984.

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