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@inbook{2234537,
author = {Růžek, Daniel},
address = {Cambridge},
booktitle = {Annual Reports in Medicinal Chemistry : Medicinal Chemistry of Tick-Borne Encephalitis},
doi = {http://dx.doi.org/10.1016/bs.armc.2022.08.002},
keywords = {Tick-borne encephalitis; Animal models; Antivirals; Preclinical testing},
howpublished = {tištěná verze "print"},
language = {eng},
location = {Cambridge},
isbn = {978-0-323-98893-3},
pages = {243-256},
publisher = {Elsevier},
title = {Animal models of tick-borne encephalitis for preclinical antiviral research},
url = {https://doi.org/10.1016/bs.armc.2022.08.002},
year = {2022}
}
TY - CHAP
ID - 2234537
AU - Růžek, Daniel
PY - 2022
TI - Animal models of tick-borne encephalitis for preclinical antiviral research
VL - 58
PB - Elsevier
CY - Cambridge
SN - 9780323988933
KW - Tick-borne encephalitis
KW - Animal models
KW - Antivirals
KW - Preclinical testing
UR - https://doi.org/10.1016/bs.armc.2022.08.002
N2 - Tick-borne encephalitis (TBE), a central nervous system infection caused by the TBE virus (TBEV), is a public health concern in large, forested areas of Europe and Asia. The disease can manifest as a mild, febrile, flu-like illness, but it can also progress to meningitis, encephalitis, or meningoencephalitis. Myelitis and spinal paralysis may also occur. To date, there is no specific drug approved for the treatment of TBE. An essential prerequisite for the development of new specific therapies for TBE is the availability of suitable animal models for TBE. There are several animal models for TBE that include laboratory mice, rats, and nonhuman primates. None of these existing models is ideal for recapitulating all aspects of TBE in humans. Nevertheless, they are useful for studying different aspects of TBE pathogenesis and for testing and developing new therapeutic countermeasures.
ER -
RŮŽEK, Daniel. Animal models of tick-borne encephalitis for preclinical antiviral research. In \textit{Annual Reports in Medicinal Chemistry : Medicinal Chemistry of Tick-Borne Encephalitis}. Cambridge: Elsevier, 2022, s.~243-256. 58. ISBN~978-0-323-98893-3. Dostupné z: https://dx.doi.org/10.1016/bs.armc.2022.08.002.
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