| KOZUBEK, Stanislav, Emilie LUKÁŠOVÁ, Andrea MAREČKOVÁ, Magdalena SKALNÍKOVÁ, Michal KOZUBEK, Eva BÁRTOVÁ, Václav KROHA, Eva KRAHULCOVÁ and Jana ŠLOTOVÁ. The topological organization of chromosomes 9 and 22 in cell nuclei has a determinative role in the induction of t(9,22) translocations and in the pathogenesis of t(9,22) leukemias. Chromosoma. Berlin: Springer-Verlag, 1999, vol. 108, No 7, p. 426-435. ISSN 0009-5915. |
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@article{223471,
author = {Kozubek, Stanislav and Lukášová, Emilie and Marečková, Andrea and Skalníková, Magdalena and Kozubek, Michal and Bártová, Eva and Kroha, Václav and Krahulcová, Eva and Šlotová, Jana},
article_location = {Berlin},
article_number = {7},
keywords = {nuclear topography; chromosome 22; chromosome 9; CML; ABL; BCR; haemoblastoses},
language = {eng},
issn = {0009-5915},
journal = {Chromosoma},
title = {The topological organization of chromosomes 9 and 22 in cell nuclei has a determinative role in the induction of t(9,22) translocations and in the pathogenesis of t(9,22) leukemias},
volume = {108},
year = {1999}
}
TY - JOUR
ID - 223471
AU - Kozubek, Stanislav - Lukášová, Emilie - Marečková, Andrea - Skalníková, Magdalena - Kozubek, Michal - Bártová, Eva - Kroha, Václav - Krahulcová, Eva - Šlotová, Jana
PY - 1999
TI - The topological organization of chromosomes 9 and 22 in cell nuclei has a determinative role in the induction of t(9,22) translocations and in the pathogenesis of t(9,22) leukemias
JF - Chromosoma
VL - 108
IS - 7
SP - 426
EP - 426
PB - Springer-Verlag
SN - 00095915
KW - nuclear topography
KW - chromosome 22
KW - chromosome 9
KW - CML
KW - ABL
KW - BCR
KW - haemoblastoses
N2 - The neighborhood relationships of chromosomes can be of great importance for basic cellular processes such as gene expression or translocation induction. In this study, the topological organization of chromosomes 9 and 22 was investigated in cell nuclei of Go-lymphocytes. We found that the domains of both chromosomes are predominantly located in the central region of cell nuclei. In addition to this, chromosomes 9 and 22 were frequently associated in pairs detected as false positive ABL-BCR fusions. Both effects might substantially increase the probability of interaction between chromosomes. Because of this, exchange aberrations were studied in chromosomes 9 and 22 of human lymphocytes irradiated by neutrons. The rate of aberration induction between these chromosomes was 11 times higher than the expected frequency based on the fractional molecular weight of these chromosomes. We show that the increased rate of exchanges between chromosome 9 and 22 induced by neutrons corresponds to the neighborhood relationships of both chromosomes. Similar topological characteristics of ABL and BCR genes were found in several cell lines: T- and B-lymphocytes, HL60 cells and bone-marrow cells. This finding suggests that the mentioned specific chromatin structure might be responsible for the high rate of the induction of t(9;22) positive leukemias in the human population.
ER -
KOZUBEK, Stanislav, Emilie LUKÁŠOVÁ, Andrea MAREČKOVÁ, Magdalena SKALNÍKOVÁ, Michal KOZUBEK, Eva BÁRTOVÁ, Václav KROHA, Eva KRAHULCOVÁ and Jana ŠLOTOVÁ. The topological organization of chromosomes 9 and 22 in cell nuclei has a determinative role in the induction of t(9,22) translocations and in the pathogenesis of t(9,22) leukemias. \textit{Chromosoma}. Berlin: Springer-Verlag, 1999, vol.~108, No~7, p.~426-435. ISSN~0009-5915.
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