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@proceedings{2235181,
author = {Klásková, Eva and Juřica, Jan and Hammer, Tomáš and Máchalová, Alena and Mlčůchová, Natálie and Vyklická, Kateřina and Brenerová, Petra and Bořilová Linhartová, Petra and Zendulka, Ondřej},
booktitle = {19th International Medical Postgraduate Conference, From Bench to Bedside in PhD Research Projects},
keywords = {cytochrome P450; salidroside; metabolic activity; drug-drug interactions},
language = {eng},
title = {In vivo and in vitro effects of salidroside on liver cytochrome P450},
url = {https://www.lfhk.cuni.cz/getattachment/Veda,-zahranici/Vedecka-setkani/Mezinarodni-konference-studentu-DSP/Archiv-mezinarodnich-konferenci-studentu-DSP/Abstracts_19th_IMPC_2022.pdf.aspx/?lang=en-GB},
year = {2022}
}
TY - CONF
ID - 2235181
AU - Klásková, Eva - Juřica, Jan - Hammer, Tomáš - Máchalová, Alena - Mlčůchová, Natálie - Vyklická, Kateřina - Brenerová, Petra - Bořilová Linhartová, Petra - Zendulka, Ondřej
PY - 2022
TI - In vivo and in vitro effects of salidroside on liver cytochrome P450
KW - cytochrome P450
KW - salidroside
KW - metabolic activity
KW - drug-drug interactions
UR - https://www.lfhk.cuni.cz/getattachment/Veda,-zahranici/Vedecka-setkani/Mezinarodni-konference-studentu-DSP/Archiv-mezinarodnich-konferenci-studentu-DSP/Abstracts_19th_IMPC_2022.pdf.aspx/?lang=en-GB
N2 - Salidroside (SAL) is one of the main active compounds of Rhodiola rosea, a herb with antidepressant and anxiolytic potential proven by clinical studies. Cytochromes P450 (CYP) are enzymes responsible for the metabolism of 70-80 % of medicaments in clinical practice. Since R. rosea is the ingredient of various over-the-counter food supplements, we have focused on its potential for pharmacokinetic interactions with the most important CYP isoforms.
ER -
KLÁSKOVÁ, Eva, Jan JUŘICA, Tomáš HAMMER, Alena MÁCHALOVÁ, Natálie MLČŮCHOVÁ, Kateřina VYKLICKÁ, Petra BRENEROVÁ, Petra BOŘILOVÁ LINHARTOVÁ a Ondřej ZENDULKA. In vivo and in vitro effects of salidroside on liver cytochrome P450. In \textit{19th International Medical Postgraduate Conference, From Bench to Bedside in PhD Research Projects}. 2022.
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