In vivo and in vitro effects of salidroside on liver cytochrome
P450

a 2022

In vivo and in vitro effects of salidroside on liver cytochrome P450

KLÁSKOVÁ, Eva, Jan JUŘICA, Tomáš HAMMER, Alena MÁCHALOVÁ, Natálie MLČŮCHOVÁ et. al.

Basic information

Original name

In vivo and in vitro effects of salidroside on liver cytochrome P450

Authors

KLÁSKOVÁ, Eva (203 Czech Republic, guarantor, belonging to the institution), Jan JUŘICA (203 Czech Republic, belonging to the institution), Tomáš HAMMER (203 Czech Republic, belonging to the institution), Alena MÁCHALOVÁ (203 Czech Republic, belonging to the institution), Natálie MLČŮCHOVÁ (203 Czech Republic), Kateřina VYKLICKÁ (203 Czech Republic, belonging to the institution), Petra BRENEROVÁ (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution) and Ondřej ZENDULKA (203 Czech Republic, belonging to the institution)

Edition

19th International Medical Postgraduate Conference, From Bench to Bedside in PhD Research Projects, 2022

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Abstract book

RIV identification code

RIV/00216224:14110/22:00127282

Organization unit

Faculty of Medicine

Keywords in English

cytochrome P450; salidroside; metabolic activity; drug-drug interactions

Změněno: 5/4/2023 13:10, Mgr. Tereza Miškechová

Abstract

V originále

Salidroside (SAL) is one of the main active compounds of Rhodiola rosea, a herb with antidepressant and anxiolytic potential proven by clinical studies. Cytochromes P450 (CYP) are enzymes responsible for the metabolism of 70-80 % of medicaments in clinical practice. Since R. rosea is the ingredient of various over-the-counter food supplements, we have focused on its potential for pharmacokinetic interactions with the most important CYP isoforms.

Links

LM2018121, research and development project

Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

MUNI/A/1440/2021, interní kód MU

Name: Preklinický a klinický výzkum Farmakologického ústavu v oblasti farmakokinetiky, neurobiologie závislostí a personalizované farmakoterapie v onkologii (Acronym: Farm-Pre-Klin)

Investor: Masaryk University

MUNI/IGA/1261/2020, interní kód MU

Name: The influence of promising herbal antidepressant salidroside on drug metabolizing enzymes

Investor: Masaryk University

Citovat

KLÁSKOVÁ, Eva, Jan JUŘICA, Tomáš HAMMER, Alena MÁCHALOVÁ, Natálie MLČŮCHOVÁ, Kateřina VYKLICKÁ, Petra BRENEROVÁ, Petra BOŘILOVÁ LINHARTOVÁ and Ondřej ZENDULKA. In vivo and in vitro effects of salidroside on liver cytochrome P450. In 19th International Medical Postgraduate Conference, From Bench to Bedside in PhD Research Projects. 2022.

@proceedings{2235181,
   author = {Klásková, Eva and Juřica, Jan and Hammer, Tomáš and Máchalová, Alena and Mlčůchová, Natálie and Vyklická, Kateřina and Brenerová, Petra and Bořilová Linhartová, Petra and Zendulka, Ondřej},
   booktitle = {19th International Medical Postgraduate Conference, From Bench to Bedside in PhD Research Projects},
   keywords = {cytochrome P450; salidroside; metabolic activity; drug-drug interactions},
   language = {eng},
   title = {In vivo and in vitro effects of salidroside on liver cytochrome P450},
   url = {https://www.lfhk.cuni.cz/getattachment/Veda,-zahranici/Vedecka-setkani/Mezinarodni-konference-studentu-DSP/Archiv-mezinarodnich-konferenci-studentu-DSP/Abstracts_19th_IMPC_2022.pdf.aspx/?lang=en-GB},
   year = {2022}
}

TY  - CONF
ID  - 2235181
AU  - Klásková, Eva - Juřica, Jan - Hammer, Tomáš - Máchalová, Alena - Mlčůchová, Natálie - Vyklická, Kateřina - Brenerová, Petra - Bořilová Linhartová, Petra - Zendulka, Ondřej
PY  - 2022
TI  - In vivo and in vitro effects of salidroside on liver cytochrome P450
KW  - cytochrome P450
KW  - salidroside
KW  - metabolic activity
KW  - drug-drug interactions
UR  - https://www.lfhk.cuni.cz/getattachment/Veda,-zahranici/Vedecka-setkani/Mezinarodni-konference-studentu-DSP/Archiv-mezinarodnich-konferenci-studentu-DSP/Abstracts_19th_IMPC_2022.pdf.aspx/?lang=en-GB
N2  - Salidroside (SAL) is one of the main active compounds of Rhodiola rosea, a herb with antidepressant and anxiolytic potential proven by clinical studies. Cytochromes P450 (CYP) are enzymes responsible for the metabolism of 70-80 % of medicaments in clinical practice. Since R. rosea is the ingredient of various over-the-counter food supplements, we have focused on its potential for pharmacokinetic interactions with the most important CYP isoforms.
ER  -

KLÁSKOVÁ, Eva, Jan JUŘICA, Tomáš HAMMER, Alena MÁCHALOVÁ, Natálie MLČŮCHOVÁ, Kateřina VYKLICKÁ, Petra BRENEROVÁ, Petra BOŘILOVÁ LINHARTOVÁ and Ondřej ZENDULKA. In vivo and in vitro effects of salidroside on liver cytochrome P450. In \textit{19th International Medical Postgraduate Conference, From Bench to Bedside in PhD Research Projects}. 2022.

Detailed Information on Publication Record