Inter-individual differences in baseline dynamic functional
connectivity are linked to cognitive aftereffects of tDCS

J 2022

Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS

PUPÍKOVÁ, Monika, Patrik ŠIMKO, Martin LAMOŠ, Martin GAJDOŠ, Irena REKTOROVÁ et. al.

Základní údaje

Originální název

Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS

Autoři

PUPÍKOVÁ, Monika (203 Česká republika, domácí), Patrik ŠIMKO (703 Slovensko, domácí), Martin LAMOŠ (203 Česká republika, domácí), Martin GAJDOŠ (203 Česká republika, domácí) a Irena REKTOROVÁ (203 Česká republika, garant, domácí)

Vydání

Scientific Reports, Berlin, Springer Nature, 2022, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.600

Kód RIV

RIV/00216224:14740/22:00127330

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1038/s41598-022-25016-5

UT WoS

000914086600057

Klíčová slova anglicky

tDCS; baseline dynamic functional connectivity

Štítky

14110127, 14110132, CF MAFIL, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 10. 2024 10:26, Ing. Jana Kuchtová

Anotace

V originále

Transcranial direct current stimulation (tDCS) has the potential to modulate cognitive training in healthy aging; however, results from various studies have been inconsistent. We hypothesized that inter-individual differences in baseline brain state may contribute to the varied results. We aimed to explore whether baseline resting-state dynamic functional connectivity (rs-dFC) and/or conventional resting-state static functional connectivity (rs-sFC) may be related to the magnitude of cognitive aftereffects of tDCS. To achieve this aim, we used data from our double-blind randomized sham-controlled cross-over tDCS trial in 25 healthy seniors in which bifrontal tDCS combined with cognitive training had induced significant behavioral aftereffects. We performed a backward regression analysis including rs-sFC/rs-dFC measures to explain the variability in the magnitude of tDCS-induced improvements in visual object-matching task (VOMT) accuracy. Rs-dFC analysis revealed four rs-dFC states. The occurrence rate of a rs-dFC state 4, characterized by a high correlation between the left fronto-parietal control network and the language network, was significantly associated with tDCS-induced VOMT accuracy changes. The rs-sFC measure was not significantly associated with the cognitive outcome. We show that flexibility of the brain state representing readiness for top-down control of object identification implicated in the studied task is linked to the tDCS-enhanced task accuracy.

Návaznosti

MUNI/A/1155/2021, interní kód MU

Název: Analýza kognice a vědomí pomocí funkčních metod

Investor: Masarykova univerzita, Analýza kognice a vědomí pomocí funkčních metod

NV18-04-00256, projekt VaV

Název: Efekt transkraniální stimulace tDCS na zrakovou pozornost u pacientů s mírnou kognitivní poruchou - studie kombinující MRI a neinvazivní mozkovou stimulaci

Investor: Ministerstvo zdravotnictví ČR, The effect of transcranial direct current stimulation on visual attention in mild cognitive impairment – a combined fMRI and non-invasive brain stimulation study

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

PUPÍKOVÁ, Monika, Patrik ŠIMKO, Martin LAMOŠ, Martin GAJDOŠ a Irena REKTOROVÁ. Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS. Scientific Reports. Berlin: Springer Nature, 2022, roč. 12, č. 1, s. 1-12. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-022-25016-5.

@article{2236213,
   author = {Pupíková, Monika and Šimko, Patrik and Lamoš, Martin and Gajdoš, Martin and Rektorová, Irena},
   article_location = {Berlin},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-022-25016-5},
   keywords = {tDCS; baseline dynamic functional connectivity},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS},
   url = {https://www.nature.com/articles/s41598-022-25016-5},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 2236213
AU  - Pupíková, Monika - Šimko, Patrik - Lamoš, Martin - Gajdoš, Martin - Rektorová, Irena
PY  - 2022
TI  - Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS
JF  - Scientific Reports
VL  - 12
IS  - 1
SP  - 1-12
EP  - 1-12
PB  - Springer Nature
SN  - 20452322
KW  - tDCS
KW  - baseline dynamic functional connectivity
UR  - https://www.nature.com/articles/s41598-022-25016-5
N2  - Transcranial direct current stimulation (tDCS) has the potential to modulate cognitive training in healthy aging; however, results from various studies have been inconsistent. We hypothesized that inter-individual differences in baseline brain state may contribute to the varied results. We aimed to explore whether baseline resting-state dynamic functional connectivity (rs-dFC) and/or conventional resting-state static functional connectivity (rs-sFC) may be related to the magnitude of cognitive aftereffects of tDCS. To achieve this aim, we used data from our double-blind randomized sham-controlled cross-over tDCS trial in 25 healthy seniors in which bifrontal tDCS combined with cognitive training had induced significant behavioral aftereffects. We performed a backward regression analysis including rs-sFC/rs-dFC measures to explain the variability in the magnitude of tDCS-induced improvements in visual object-matching task (VOMT) accuracy. Rs-dFC analysis revealed four rs-dFC states. The occurrence rate of a rs-dFC state 4, characterized by a high correlation between the left fronto-parietal control network and the language network, was significantly associated with tDCS-induced VOMT accuracy changes. The rs-sFC measure was not significantly associated with the cognitive outcome. We show that flexibility of the brain state representing readiness for top-down control of object identification implicated in the studied task is linked to the tDCS-enhanced task accuracy.
ER  -

PUPÍKOVÁ, Monika, Patrik ŠIMKO, Martin LAMOŠ, Martin GAJDOŠ a Irena REKTOROVÁ. Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS. \textit{Scientific Reports}. Berlin: Springer Nature, 2022, roč.~12, č.~1, s.~1-12. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-022-25016-5.

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