Comedication with corticosteroids and nonsteroidal
antiphlogistics does not affect PD-L1 expression in non-small
cell lung cancer

J 2022

Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer

SVATON, Martin, Marie DROSSLEROVA, Ondrej FISCHER, Miloslav MAREL, Michal HRNCIARIK et. al.

Základní údaje

Originální název

Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer

Autoři

SVATON, Martin (203 Česká republika, garant), Marie DROSSLEROVA (203 Česká republika), Ondrej FISCHER (203 Česká republika), Miloslav MAREL (203 Česká republika), Michal HRNCIARIK (203 Česká republika), Ondřej VENCLÍČEK (203 Česká republika, domácí), Petr ZUNA (203 Česká republika), Michal SVOBODA (203 Česká republika), Jiri BLAZEK (203 Česká republika), Monika BRATOVÁ (203 Česká republika, domácí), Andrea MULLEROVA (203 Česká republika), Bohuslava VANKOVA (203 Česká republika) a Daniel KREJCI (203 Česká republika)

Vydání

TRANSLATIONAL CANCER RESEARCH, PEOPLES R CHINA, AME PUBL CO, 2022, 2218-676X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30203 Respiratory systems

Stát vydavatele

Čína

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 0.900

Kód RIV

RIV/00216224:14110/22:00127430

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.21037/tcr-22-260

UT WoS

000835374900001

Klíčová slova anglicky

Non-small cell lung cancer (NSCLC); lung cancer; programmed death-ligand 1 (PD-L1); non-steroidal anti-inflammatory drugs (NSAIDs); corticosteroids

Štítky

14110215, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 2. 2023 08:52, Mgr. Tereza Miškechová

Anotace

V originále

Background: Programmed death-ligand 1 (PD-L1) expression is a standard predictor in the selection of immunotherapy for locally advanced/advanced non-small cell lung cancer (NSCLC). However, comedication with corticosteroids or non-steroidal anti-inflammatory drugs (NSAIDs) may influence the effectiveness of this treatment as documented in several previous studies. Due to certain molecular linkages between PD-L1 and corticosteroids or NSAIDs, we therefore addressed the question of whether there is a relationship between PD-L1 expression in NSCLC and the use of this comedication. Methods: This is a retrospective study using the Czech tumor registry LUng CAncer focuS (LUCAS), from which patient data were drawn. Independence of two categorical parameters was tested by Pearson's chi-square test. Results: In our group of 1,148 patients, we observed no significant relationship between PD-L1 expression and the use of corticosteroids or NSAIDs. Conclusions: According to our data, treatment with corticosteroids or NSAIDs during biopsy does not affect the expression of PD-L1 and it is therefore not necessary to take this treatment into account in this regard.

Citovat

SVATON, Martin, Marie DROSSLEROVA, Ondrej FISCHER, Miloslav MAREL, Michal HRNCIARIK, Ondřej VENCLÍČEK, Petr ZUNA, Michal SVOBODA, Jiri BLAZEK, Monika BRATOVÁ, Andrea MULLEROVA, Bohuslava VANKOVA a Daniel KREJCI. Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer. TRANSLATIONAL CANCER RESEARCH. PEOPLES R CHINA: AME PUBL CO, 2022, roč. 11, č. 9, s. 3017-3023. ISSN 2218-676X. Dostupné z: https://dx.doi.org/10.21037/tcr-22-260.

@article{2239428,
   author = {Svaton, Martin and Drosslerova, Marie and Fischer, Ondrej and Marel, Miloslav and Hrnciarik, Michal and Venclíček, Ondřej and Zuna, Petr and Svoboda, Michal and Blazek, Jiri and Bratová, Monika and Mullerova, Andrea and Vankova, Bohuslava and Krejci, Daniel},
   article_location = {PEOPLES R CHINA},
   article_number = {9},
   doi = {http://dx.doi.org/10.21037/tcr-22-260},
   keywords = {Non-small cell lung cancer (NSCLC); lung cancer; programmed death-ligand 1 (PD-L1); non-steroidal anti-inflammatory drugs (NSAIDs); corticosteroids},
   language = {eng},
   issn = {2218-676X},
   journal = {TRANSLATIONAL CANCER RESEARCH},
   title = {Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer},
   url = {https://tcr.amegroups.com/article/view/66943/html},
   volume = {11},
   year = {2022}
}

TY  - JOUR
ID  - 2239428
AU  - Svaton, Martin - Drosslerova, Marie - Fischer, Ondrej - Marel, Miloslav - Hrnciarik, Michal - Venclíček, Ondřej - Zuna, Petr - Svoboda, Michal - Blazek, Jiri - Bratová, Monika - Mullerova, Andrea - Vankova, Bohuslava - Krejci, Daniel
PY  - 2022
TI  - Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer
JF  - TRANSLATIONAL CANCER RESEARCH
VL  - 11
IS  - 9
SP  - 3017-3023
EP  - 3017-3023
PB  - AME PUBL CO
SN  - 2218676X
KW  - Non-small cell lung cancer (NSCLC)
KW  - lung cancer
KW  - programmed death-ligand 1 (PD-L1)
KW  - non-steroidal anti-inflammatory drugs (NSAIDs)
KW  - corticosteroids
UR  - https://tcr.amegroups.com/article/view/66943/html
N2  - Background: Programmed death-ligand 1 (PD-L1) expression is a standard predictor in the selection of immunotherapy for locally advanced/advanced non-small cell lung cancer (NSCLC). However, comedication with corticosteroids or non-steroidal anti-inflammatory drugs (NSAIDs) may influence the effectiveness of this treatment as documented in several previous studies. Due to certain molecular linkages between PD-L1 and corticosteroids or NSAIDs, we therefore addressed the question of whether there is a relationship between PD-L1 expression in NSCLC and the use of this comedication. Methods: This is a retrospective study using the Czech tumor registry LUng CAncer focuS (LUCAS), from which patient data were drawn. Independence of two categorical parameters was tested by Pearson's chi-square test. Results: In our group of 1,148 patients, we observed no significant relationship between PD-L1 expression and the use of corticosteroids or NSAIDs. Conclusions: According to our data, treatment with corticosteroids or NSAIDs during biopsy does not affect the expression of PD-L1 and it is therefore not necessary to take this treatment into account in this regard.
ER  -

SVATON, Martin, Marie DROSSLEROVA, Ondrej FISCHER, Miloslav MAREL, Michal HRNCIARIK, Ondřej VENCLÍČEK, Petr ZUNA, Michal SVOBODA, Jiri BLAZEK, Monika BRATOVÁ, Andrea MULLEROVA, Bohuslava VANKOVA a Daniel KREJCI. Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer. \textit{TRANSLATIONAL CANCER RESEARCH}. PEOPLES R CHINA: AME PUBL CO, 2022, roč.~11, č.~9, s.~3017-3023. ISSN~2218-676X. Dostupné z: https://dx.doi.org/10.21037/tcr-22-260.

Podrobný výpis o publikaci