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@article{2239497,
author = {Říha, Pavel and Doležalová, Irena and Mareček, Radek and Lamoš, Martin and Bartoňová, Michaela and Kojan, Martin and Mikl, Michal and Gajdoš, Martin and Vojtíšek, Lubomír and Bartoň, Marek and Strýček, Ondřej and Pail, Martin and Brázdil, Milan and Rektor, Ivan},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-022-19121-8},
keywords = {FOCAL CORTICAL DYSPLASIATEMPORAL-LOBE EPILEPSYREGIONAL HOMOGENEITYIMPROVES DETECTIONABNORMALITIESCHILDRENFEATURESSURGERYEEG},
language = {eng},
issn = {2045-2322},
journal = {Nature Scientific Reports},
title = {Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy},
url = {https://www.nature.com/articles/s41598-022-19121-8},
volume = {12},
year = {2022}
}
TY - JOUR
ID - 2239497
AU - Říha, Pavel - Doležalová, Irena - Mareček, Radek - Lamoš, Martin - Bartoňová, Michaela - Kojan, Martin - Mikl, Michal - Gajdoš, Martin - Vojtíšek, Lubomír - Bartoň, Marek - Strýček, Ondřej - Pail, Martin - Brázdil, Milan - Rektor, Ivan
PY - 2022
TI - Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy
JF - Nature Scientific Reports
VL - 12
IS - 1
SP - 15158
EP - 15158
PB - NATURE RESEARCH
SN - 20452322
KW - FOCAL CORTICAL DYSPLASIATEMPORAL-LOBE EPILEPSYREGIONAL HOMOGENEITYIMPROVES DETECTIONABNORMALITIESCHILDRENFEATURESSURGERYEEG
UR - https://www.nature.com/articles/s41598-022-19121-8
N2 - The objective was to determine the optimal combination of multimodal imaging methods (IMs) for localizing the epileptogenic zone (EZ) in patients with MR-negative drug-resistant epilepsy. Data from 25 patients with MR-negative focal epilepsy (age 30 +/- 10 years, 16M/9F) who underwent surgical resection of the EZ and from 110 healthy controls (age 31 +/- 9 years; 56M/54F) were used to evaluate IMs based on 3T MRI, FDG-PET, HD-EEG, and SPECT. Patients with successful outcomes and/or positive histological findings were evaluated. From 38 IMs calculated per patient, 13 methods were selected by evaluating the mutual similarity of the methods and the accuracy of the EZ localization. The best results in postsurgical patients for EZ localization were found for ictal/ interictal SPECT (SISCOM), FDG-PET, arterial spin labeling (ASL), functional regional homogeneity (ReHo), gray matter volume (GMV), cortical thickness, HD electrical source imaging (ESI-HD), amplitude of low-frequency fluctuation (ALFF), diffusion tensor imaging, and kurtosis imaging. Combining IMs provides the method with the most accurate EZ identification in MR-negative epilepsy. The PET, SISCOM, and selected MRI-post-processing techniques are useful for EZ localization for surgical tailoring.
ER -
ŘÍHA, Pavel, Irena DOLEŽALOVÁ, Radek MAREČEK, Martin LAMOŠ, Michaela BARTOŇOVÁ, Martin KOJAN, Michal MIKL, Martin GAJDOŠ, Lubomír VOJTÍŠEK, Marek BARTOŇ, Ondřej STRÝČEK, Martin PAIL, Milan BRÁZDIL a Ivan REKTOR. Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy. \textit{Nature Scientific Reports}. London: NATURE RESEARCH, 2022, roč.~12, č.~1, s.~15158-15167. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-022-19121-8.
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