Multimodal combination of neuroimaging methods for localizing
the epileptogenic zone in MR-negative epilepsy

J 2022

Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy

ŘÍHA, Pavel, Irena DOLEŽALOVÁ, Radek MAREČEK, Martin LAMOŠ, Michaela BARTOŇOVÁ et. al.

Základní údaje

Originální název

Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy

Autoři

ŘÍHA, Pavel (203 Česká republika, domácí), Irena DOLEŽALOVÁ (203 Česká republika, domácí), Radek MAREČEK (203 Česká republika, domácí), Martin LAMOŠ (203 Česká republika, domácí), Michaela BARTOŇOVÁ (703 Slovensko, domácí), Martin KOJAN (703 Slovensko, domácí), Michal MIKL (203 Česká republika, domácí), Martin GAJDOŠ (203 Česká republika, domácí), Lubomír VOJTÍŠEK (203 Česká republika, domácí), Marek BARTOŇ (203 Česká republika, domácí), Ondřej STRÝČEK (203 Česká republika, domácí), Martin PAIL (203 Česká republika, domácí), Milan BRÁZDIL (203 Česká republika, domácí) a Ivan REKTOR (203 Česká republika, garant, domácí)

Vydání

Nature Scientific Reports, London, NATURE RESEARCH, 2022, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.600

Kód RIV

RIV/00216224:14740/22:00127439

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1038/s41598-022-19121-8

UT WoS

000852630800033

Klíčová slova anglicky

FOCAL CORTICAL DYSPLASIATEMPORAL-LOBE EPILEPSYREGIONAL HOMOGENEITYIMPROVES DETECTIONABNORMALITIESCHILDRENFEATURESSURGERYEEG

Štítky

14110127, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 10. 2024 10:37, Ing. Jana Kuchtová

Anotace

V originále

The objective was to determine the optimal combination of multimodal imaging methods (IMs) for localizing the epileptogenic zone (EZ) in patients with MR-negative drug-resistant epilepsy. Data from 25 patients with MR-negative focal epilepsy (age 30 +/- 10 years, 16M/9F) who underwent surgical resection of the EZ and from 110 healthy controls (age 31 +/- 9 years; 56M/54F) were used to evaluate IMs based on 3T MRI, FDG-PET, HD-EEG, and SPECT. Patients with successful outcomes and/or positive histological findings were evaluated. From 38 IMs calculated per patient, 13 methods were selected by evaluating the mutual similarity of the methods and the accuracy of the EZ localization. The best results in postsurgical patients for EZ localization were found for ictal/ interictal SPECT (SISCOM), FDG-PET, arterial spin labeling (ASL), functional regional homogeneity (ReHo), gray matter volume (GMV), cortical thickness, HD electrical source imaging (ESI-HD), amplitude of low-frequency fluctuation (ALFF), diffusion tensor imaging, and kurtosis imaging. Combining IMs provides the method with the most accurate EZ identification in MR-negative epilepsy. The PET, SISCOM, and selected MRI-post-processing techniques are useful for EZ localization for surgical tailoring.

Návaznosti

NU21-04-00254, projekt VaV

Název: Detekce zóny počátku záchvatu u multi-lezionální epilepsie s užitím multimodálního neurozobrazování (Akronym: MultiEPI)

Investor: Ministerstvo zdravotnictví ČR, Detekce zóny počátku záchvatu u multi-lezionální epilepsie s užitím multimodálního neurozobrazování, Podprogram 1 - standardní

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

ŘÍHA, Pavel, Irena DOLEŽALOVÁ, Radek MAREČEK, Martin LAMOŠ, Michaela BARTOŇOVÁ, Martin KOJAN, Michal MIKL, Martin GAJDOŠ, Lubomír VOJTÍŠEK, Marek BARTOŇ, Ondřej STRÝČEK, Martin PAIL, Milan BRÁZDIL a Ivan REKTOR. Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy. Nature Scientific Reports. London: NATURE RESEARCH, 2022, roč. 12, č. 1, s. 15158-15167. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-022-19121-8.

@article{2239497,
   author = {Říha, Pavel and Doležalová, Irena and Mareček, Radek and Lamoš, Martin and Bartoňová, Michaela and Kojan, Martin and Mikl, Michal and Gajdoš, Martin and Vojtíšek, Lubomír and Bartoň, Marek and Strýček, Ondřej and Pail, Martin and Brázdil, Milan and Rektor, Ivan},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-022-19121-8},
   keywords = {FOCAL CORTICAL DYSPLASIATEMPORAL-LOBE EPILEPSYREGIONAL HOMOGENEITYIMPROVES DETECTIONABNORMALITIESCHILDRENFEATURESSURGERYEEG},
   language = {eng},
   issn = {2045-2322},
   journal = {Nature Scientific Reports},
   title = {Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy},
   url = {https://www.nature.com/articles/s41598-022-19121-8},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 2239497
AU  - Říha, Pavel - Doležalová, Irena - Mareček, Radek - Lamoš, Martin - Bartoňová, Michaela - Kojan, Martin - Mikl, Michal - Gajdoš, Martin - Vojtíšek, Lubomír - Bartoň, Marek - Strýček, Ondřej - Pail, Martin - Brázdil, Milan - Rektor, Ivan
PY  - 2022
TI  - Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy
JF  - Nature Scientific Reports
VL  - 12
IS  - 1
SP  - 15158
EP  - 15158
PB  - NATURE RESEARCH
SN  - 20452322
KW  - FOCAL CORTICAL DYSPLASIATEMPORAL-LOBE EPILEPSYREGIONAL HOMOGENEITYIMPROVES DETECTIONABNORMALITIESCHILDRENFEATURESSURGERYEEG
UR  - https://www.nature.com/articles/s41598-022-19121-8
N2  - The objective was to determine the optimal combination of multimodal imaging methods (IMs) for localizing the epileptogenic zone (EZ) in patients with MR-negative drug-resistant epilepsy. Data from 25 patients with MR-negative focal epilepsy (age 30 +/- 10 years, 16M/9F) who underwent surgical resection of the EZ and from 110 healthy controls (age 31 +/- 9 years; 56M/54F) were used to evaluate IMs based on 3T MRI, FDG-PET, HD-EEG, and SPECT. Patients with successful outcomes and/or positive histological findings were evaluated. From 38 IMs calculated per patient, 13 methods were selected by evaluating the mutual similarity of the methods and the accuracy of the EZ localization. The best results in postsurgical patients for EZ localization were found for ictal/ interictal SPECT (SISCOM), FDG-PET, arterial spin labeling (ASL), functional regional homogeneity (ReHo), gray matter volume (GMV), cortical thickness, HD electrical source imaging (ESI-HD), amplitude of low-frequency fluctuation (ALFF), diffusion tensor imaging, and kurtosis imaging. Combining IMs provides the method with the most accurate EZ identification in MR-negative epilepsy. The PET, SISCOM, and selected MRI-post-processing techniques are useful for EZ localization for surgical tailoring.
ER  -

ŘÍHA, Pavel, Irena DOLEŽALOVÁ, Radek MAREČEK, Martin LAMOŠ, Michaela BARTOŇOVÁ, Martin KOJAN, Michal MIKL, Martin GAJDOŠ, Lubomír VOJTÍŠEK, Marek BARTOŇ, Ondřej STRÝČEK, Martin PAIL, Milan BRÁZDIL a Ivan REKTOR. Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy. \textit{Nature Scientific Reports}. London: NATURE RESEARCH, 2022, roč.~12, č.~1, s.~15158-15167. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-022-19121-8.

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