The Human Mycobiome: Colonization, Composition and the Role in
Health and Disease

J 2022

The Human Mycobiome: Colonization, Composition and the Role in Health and Disease

BELVONCIKOVA, Paulina; Petra ŠPLÍCHALOVÁ; Petra VÍDEŇSKÁ a Roman GARDLIK

Základní údaje

Originální název

The Human Mycobiome: Colonization, Composition and the Role in Health and Disease

Autoři

BELVONCIKOVA, Paulina; Petra ŠPLÍCHALOVÁ; Petra VÍDEŇSKÁ a Roman GARDLIK

Vydání

Journal of Fungi, St. Alban-Anlage, MDPI, 2022, 2309-608X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10606 Microbiology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.700

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/22:00127544

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

fungi; gut mycobiome; oral mycobiome; skin mycobiome; genitourinary tract mycobiome; respiratory tract mycobiome; colonization; composition; dysbiosis

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 1. 2023 14:20, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

The mycobiome is the fungal component of the human microbial ecosystem that represents only a small part of this environment but plays an essential role in maintaining homeostasis. Colonization by fungi begins immediately after birth. The initial mycobiome is influenced by the gestational age of a newborn, birth weight, delivery method and feeding method. During a human's life, the composition of the mycobiome is further influenced by a large number of endogenous and exogenous factors. The most important factors are diet, body weight, age, sex and antibiotic and antifungal therapy. The human mycobiome inhabits the oral cavity, gastrointestinal tract, respiratory tract, urogenital tract and skin. Its composition can influence the gut-brain axis through immune and non-immune mediated crosstalk systems. It also interacts with other commensals of the ecosystem through synergistic and antagonistic relationships. Moreover, colonization of the gut by opportunistic fungal pathogens in immunocompromised individuals can lead to clinically relevant disease states. Thus, the mycobiome represents an essential part of the microbiome associated with a variety of physiological and pathological processes. This review summarizes the current knowledge on the composition of the mycobiome in specific sites of the human body and its role in health and disease.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

LM2018121, projekt VaV

Název: Výzkumná infrastruktura RECETOX (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

Přiložené soubory

2241140.pdf

Citovat

BELVONCIKOVA, Paulina; Petra ŠPLÍCHALOVÁ; Petra VÍDEŇSKÁ a Roman GARDLIK. The Human Mycobiome: Colonization, Composition and the Role in Health and Disease. Journal of Fungi. St. Alban-Anlage: MDPI, 2022, roč. 8, č. 10, s. 1-26. ISSN 2309-608X. Dostupné z: https://doi.org/10.3390/jof8101046.

@article{2241140,
   author = {Belvoncikova, Paulina and Šplíchalová, Petra and Vídeňská, Petra and Gardlik, Roman},
   article_location = {St. Alban-Anlage},
   article_number = {10},
   doi = {https://doi.org/10.3390/jof8101046},
   keywords = {fungi; gut mycobiome; oral mycobiome; skin mycobiome; genitourinary tract mycobiome; respiratory tract mycobiome; colonization; composition; dysbiosis},
   language = {eng},
   issn = {2309-608X},
   journal = {Journal of Fungi},
   title = {The Human Mycobiome: Colonization, Composition and the Role in Health and Disease},
   url = {https://www.mdpi.com/2309-608X/8/10/1046},
   volume = {8},
   year = {2022}
}

TY  - JOUR
ID  - 2241140
AU  - Belvoncikova, Paulina - Šplíchalová, Petra - Vídeňská, Petra - Gardlik, Roman
PY  - 2022
TI  - The Human Mycobiome: Colonization, Composition and the Role in Health and Disease
JF  - Journal of Fungi
VL  - 8
IS  - 10
SP  - 1-26
EP  - 1-26
PB  - MDPI
SN  - 2309608X
KW  - fungi
KW  - gut mycobiome
KW  - oral mycobiome
KW  - skin mycobiome
KW  - genitourinary tract mycobiome
KW  - respiratory tract mycobiome
KW  - colonization
KW  - composition
KW  - dysbiosis
UR  - https://www.mdpi.com/2309-608X/8/10/1046
N2  - The mycobiome is the fungal component of the human microbial ecosystem that represents only a small part of this environment but plays an essential role in maintaining homeostasis. Colonization by fungi begins immediately after birth. The initial mycobiome is influenced by the gestational age of a newborn, birth weight, delivery method and feeding method. During a human's life, the composition of the mycobiome is further influenced by a large number of endogenous and exogenous factors. The most important factors are diet, body weight, age, sex and antibiotic and antifungal therapy. The human mycobiome inhabits the oral cavity, gastrointestinal tract, respiratory tract, urogenital tract and skin. Its composition can influence the gut-brain axis through immune and non-immune mediated crosstalk systems. It also interacts with other commensals of the ecosystem through synergistic and antagonistic relationships. Moreover, colonization of the gut by opportunistic fungal pathogens in immunocompromised individuals can lead to clinically relevant disease states. Thus, the mycobiome represents an essential part of the microbiome associated with a variety of physiological and pathological processes. This review summarizes the current knowledge on the composition of the mycobiome in specific sites of the human body and its role in health and disease.
ER  -

BELVONCIKOVA, Paulina; Petra ŠPLÍCHALOVÁ; Petra VÍDEŇSKÁ a Roman GARDLIK. The Human Mycobiome: Colonization, Composition and the Role in Health and Disease. \textit{Journal of Fungi}. St. Alban-Anlage: MDPI, 2022, roč.~8, č.~10, s.~1-26. ISSN~2309-608X. Dostupné z: https://doi.org/10.3390/jof8101046.

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